Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children

CHARGE 研究儿童的青春期前和青春期后期随访

• 批准号: 10013293
• 负责人: Deborah Hall Bennett
• 金额: $ 391.24万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013293
• 关键词: Adolescence; Adolescent; Adrenal Glands; Adrenal hormone preparation; Age; Air Pollutants; Air Pollution; Anxiety; Area; Attention deficit hyperactivity disorder; Attentional deficit; Behavior Disorders; Behavioral Symptoms; Blood; Buffers; Characteristics; Chemicals; Child; Child Health; Childhood; Childhood Autism Risks from Genetics and the Environment; Cognitive; Collaborations; Collection; Crime; DNA; DNA Methylation; Data; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Elements; Enrollment; Environment; Epigenetic Process; Family; General Population; Genetic Predisposition to Disease; Goals; Green space; Heterogeneity; Hyperactive behavior; Immune; Infrastructure; Institutional Review Boards; Intervention; Investigation; Leadership; Life; Life Cycle Stages; Light; Manuals; Measures; Mediation; Mediator of activation protein; Mental Depression; Mental Health; Metals; Methods; Modeling; Monitor; Mood Disorders; Neighborhoods; Newborn Infant; Nutrient; Nutritional; Outcome; Parents; Participant; Pesticides; Pharmaceutical Preparations; Phase; Poverty; Predisposition; Preparation; Procedures; Prospective Studies; Protocols documentation; Psychopathology; Recontacts; Resources; Risk; Saliva; Sampling; Severities; Sex Differences; Site; Specimen; Spottings; Steroids; Symptoms; System; Testing; United States National Institutes of Health; Work; age group; aged; anxiety symptoms; autism spectrum disorder; autistic children; cognitive performance; cohesion; cohort; comorbidity; course development; depressive symptoms; disability; environmental chemical; follow-up; grandparent; improved; instrument; interest; intergenerational; method development; mother nutrition; neurodevelopment; novel; nutrition; phthalates; preadolescence; prenatal exposure; programs; prospective; protocol development; public health priorities; public health relevance; recruit; repository; resilience; risk variant; sex; skills; social; social factors; sociodemographics; stressor; treatment services

The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (‘baseline’) to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.

加州大学戴维斯分校拟议的回声充电研究将跟踪一群最后出现在2-5岁的儿童 确定环境化学和非化学应激源和恢复能力的年限(“基线”) 与8-12岁(青春期前)神经发育结果相关的因素 15-19岁(青春期中后期)。该项目利用收费的资源 (来自基因和环境的儿童自闭症风险)研究，自2003年以来一直在招募 三组2-5岁儿童：自闭症谱系障碍(ASD)儿童、其他 发育迟缓(DD)和具有典型发育的一般人群中的儿童(TD)。 这三组人，即充电组，将被检查是否有以下感兴趣的结果： 注意力缺陷或多动症状；认知或适应功能的变化； 严重程度或诊断；以及焦虑或抑郁的症状。试点测试将在 UG3阶段，在UH3阶段，所有人都将在青春期前或中晚期接受检查 青春期。关注的主要接触是杀虫剂、金属、空气污染、邻苯二甲酸盐、 营养成分、邻里特征和家庭因素。 此外，还提出了三个机制研究：代际研究 表观遗传特征；干血斑中金属分析的方法发展；以及性别差异 肾上腺激素与抑郁症状的关系。大约有1400个家庭符合资格 对于充电，为检验主要影响、相互作用和调解提供可靠的样本 分析。作为ECHO财团的一部分，充电团队将参与合成 结合了来自多个地点的儿童的队列，这组研究集中在 未来UH3阶段协调方案和寻求分析的神经发展 在可行的情况下，回溯样本和数据。在UG3阶段，重新充电 该团队将为表观遗传学制定协议、重新联系和招募的试点测试方法 唾液与血液的对比，以及实施肾上腺激素研究，包括增加 合规性。充电的独特功能包括对理解生命历程的贡献 两种不同类型残疾儿童的发育和一种新的肾上腺模型 性别性情感障碍与激素的关系。