Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

重温 ReCHARGE：ECHO 对童年中期和青春期的跟进

• 批准号: 10745252
• 负责人: Deborah Hall Bennett
• 金额: $ 123.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745252
• 关键词: Address; Adolescence; Adolescent; Affect; Affective; Age; Air Pollution; Aliquot; Anxiety; Area; Attention; Attention deficit hyperactivity disorder; Attentional deficit; Behavior; Behavioral; Biological; Biological Factors; Black race; Blood; Brain; Cell Differentiation process; Characteristics; Charge; Chemical Exposure; Chemicals; Child; Child Health; Childhood; Cognition; Cognitive; Cognitive deficits; Collection; Consultations; DNA; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic Factor; Emotional; Emotions; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Ethnic Origin; Ethnic Population; Evaluation; Exposure to; Family; Fetal health; Financial Hardship; Funding; Goals; Green space; Happiness; Health; Health Insurance Portability and Accountability Act; Hispanic; Home; Household; Household Products; Hyperactivity; Impairment; Impulsivity; Indigenous; Individual; Influentials; Infrastructure; Institutional Review Boards; Intellectual functioning disability; Intervention; Irritable Mood; Knowledge; Leadership; Life; Link; Measures; Mental Depression; Mental Health; Modification; Moods; Neighborhoods; Neuroglia; Neurons; Neurosciences; Occupations; Outcome; Outcome Measure; Paper; Parents; Participant; Pattern; Pediatric cohort; Peer Review; Pesticides; Phase; Plasticizers; Play; Policies; Process; Productivity; Protocols documentation; Puberty; Public Health; Publications; Race; Radiation; Regulation; Research; Resources; Risk; Risk Factors; Role; SNP array; Schools; Science; Site; Social Justice; Subgroup; Symptoms; Syndrome; System; Time; Urine; Visit; Work; Youth; adolescent health; anxiety symptoms; autism spectrum disorder; autistic; biobank; cognitive function; cognitive skill; cohort; depressive symptoms; diversity and equity; early childhood; environmental justice; environmental stressor; experience; falls; follow-up; high risk; improved; inattention; indexing; lead exposure; longitudinal design; middle childhood; multi-racial; myelination; neurodevelopment; novel; peer; phthalates; postnatal; prenatal; prognostic; programs; racial population; resilience factor; retention rate; sex; social; social factors; social stressor; stressor; substance use; synaptogenesis; therapy design; working group

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/co- authored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UCD Aim 1 will: examine environmental, social, and biologic exposures in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and identify both synergistic relationships between environmental and social factors, especially environmental justice and social justice, and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the same exposures, plus measures of PFAS and plasticizers for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. In both aims: environmental exposures include air pollution, greenspace, and home product use; social factors are neighborhood SES, family financial hardship, race, ethnicity, and parental mental health or substance use problems. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UCD will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; promote diversity and equity through our research questions, workforce, and retention strategies; and actively participate & play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.

从2016年秋季开始，加州大学戴维斯分校（UC Davis）的儿科队列ReCHARGE获得了新基金的资助