Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

重温 ReCHARGE：ECHO 对童年中期和青春期的跟进

• 批准号: 10745252
• 负责人: Deborah Hall Bennett
• 金额: $ 123.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745252
• 关键词: Address; Adolescence; Adolescent; Affect; Affective; Age; Air Pollution; Aliquot; Anxiety; Area; Attention; Attention deficit hyperactivity disorder; Attentional deficit; Behavior; Behavioral; Biological; Biological Factors; Black race; Blood; Brain; Cell Differentiation process; Characteristics; Charge; Chemical Exposure; Chemicals; Child; Child Health; Childhood; Cognition; Cognitive; Cognitive deficits; Collection; Consultations; DNA; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic Factor; Emotional; Emotions; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Ethnic Origin; Ethnic Population; Evaluation; Exposure to; Family; Fetal health; Financial Hardship; Funding; Goals; Green space; Happiness; Health; Health Insurance Portability and Accountability Act; Hispanic; Home; Household; Household Products; Hyperactivity; Impairment; Impulsivity; Indigenous; Individual; Influentials; Infrastructure; Institutional Review Boards; Intellectual functioning disability; Intervention; Irritable Mood; Knowledge; Leadership; Life; Link; Measures; Mental Depression; Mental Health; Modification; Moods; Neighborhoods; Neuroglia; Neurons; Neurosciences; Occupations; Outcome; Outcome Measure; Paper; Parents; Participant; Pattern; Pediatric cohort; Peer Review; Pesticides; Phase; Plasticizers; Play; Policies; Process; Productivity; Protocols documentation; Puberty; Public Health; Publications; Race; Radiation; Regulation; Research; Resources; Risk; Risk Factors; Role; SNP array; Schools; Science; Site; Social Justice; Subgroup; Symptoms; Syndrome; System; Time; Urine; Visit; Work; Youth; adolescent health; anxiety symptoms; autism spectrum disorder; autistic; biobank; cognitive function; cognitive skill; cohort; depressive symptoms; diversity and equity; early childhood; environmental justice; environmental stressor; experience; falls; follow-up; high risk; improved; inattention; indexing; lead exposure; longitudinal design; middle childhood; multi-racial; myelination; neurodevelopment; novel; peer; phthalates; postnatal; prenatal; prognostic; programs; racial population; resilience factor; retention rate; sex; social; social factors; social stressor; stressor; substance use; synaptogenesis; therapy design; working group

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/co- authored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UCD Aim 1 will: examine environmental, social, and biologic exposures in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and identify both synergistic relationships between environmental and social factors, especially environmental justice and social justice, and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the same exposures, plus measures of PFAS and plasticizers for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. In both aims: environmental exposures include air pollution, greenspace, and home product use; social factors are neighborhood SES, family financial hardship, race, ethnicity, and parental mental health or substance use problems. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UCD will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; promote diversity and equity through our research questions, workforce, and retention strategies; and actively participate & play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.

从2016年秋季开始，加州大学戴维斯分校的儿科队列ReCHARGE获得了新的资助。 环境对儿童健康结果的影响（ECHO）联盟，包括 近80个景点现在，在ECHO第一阶段的第7年，加州大学戴维斯分校已经招收了约900名儿童进入 来自三组神经发育儿童的ECHO：自闭症谱系障碍（ASD）， 没有自闭症症状的发育迟缓（DD）和典型发育（TD）;上传 超过55，000份数据收集表到ECHO队列数据平台，并转移了8000多份 将生物样本等分试样送至ECHO生物储存库，包括用于SNP阵列的DNA、用于 分析常见但未充分研究的家用产品和血液中的新化学物质， 多种用途。加州大学戴维斯分校ECHO团队领导了许多分析提案，撰写/合作， 撰写了40篇同行评审论文，另有50篇正在撰写中。监测组还协助 制定欧共体人道处的政策，并参加和领导各种工作组， 神经发育，化学暴露，表观遗传学，以及出版委员会， 政策执行和评价及其他。ECHO-ReCHARGE队列的重点是 神经发育的ECHO领域，由UC Davis MIND研究所提供便利。在 ECHO第2阶段，UCD目标1将：检查环境，社会和生物暴露， 与外化和内化行为的关联，即ADHD的症状，焦虑 和抑郁症在8-20岁;并确定环境之间的协同关系 和社会因素，特别是环境正义和社会正义，以及潜在的修改 儿童早期发育诊断（ASD，DD，TD）的确定性-结果关联， 年龄、性别和青春期状态。目标2将评估相同的暴露，加上PFAS的措施 和增塑剂，用于与上述行为的纵向轨迹相关联， 情感结果以及认知技能。在这两个目标中：环境暴露包括 空气污染、绿地和家庭产品使用;社会因素包括社区SES、家庭 经济困难，种族，民族和父母的心理健康或物质使用问题。 目标3将以高保真度实现最终的ECHO协议，最大限度地保留，并遵守 遵守所有ECHO政策、IRB、HIPAA和其他法规。UCD将继续广泛贡献 ECHO基础设施;通过分析和出版物推进科学;促进 通过我们的研究问题，劳动力和保留策略实现多样性和公平性; 积极参与并在这个备受瞩目的，独特的计划中发挥领导作用，以发现 儿童健康和发展的潜在风险和复原力因素。