Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

从2016年秋季开始，加州大学戴维斯分校的儿科队列ReCharge获得了新的 环境对儿童健康结果的影响(ECHO)联盟，包括 接近80个地点。现在，在ECHO第一阶段的第七年，加州大学戴维斯分校已经招收了大约900名儿童参加 来自三个神经发育组儿童的回声：自闭症谱系障碍(ASD)， 无自闭症症状的发育迟缓(DD)和典型发育(TD)；上传 超过55,000份数据收集表格发送到ECHO Cohort数据平台，并传输了超过8,000份 生物样品等量到ECHO生物储存库，包括用于SNP阵列的DNA，用于 分析常见但未被研究的家用产品中的新化学物质，以及血液中的 多种用途。加州大学戴维斯分校的Echo团队领导了一系列分析提案，撰写/联合 撰写了40篇同行评议的论文，另有50篇正在进行中。该团队还为 制定回声政策，并参与和领导各种工作组，例如 神经发育、化学暴露、表观遗传学以及出版委员会， 政策执行和评估等。回声充电队列关注的是 这是由加州大学戴维斯分校心智研究所推动的神经发育的回音区。在……里面 回声阶段2，UCD目标1将：检查环境、社会和生物暴露 与外化和内化行为的关系，即ADHD、焦虑症状 和8-20岁的抑郁；并确定了环境和环境之间的协同关系 和社会因素，特别是环境正义和社会正义，以及可能的修改 儿童早期发育诊断(ASD、DD、TD)与暴露-结果的关系 年龄、性别和青春期状况。目标2将评估相同的暴露，外加全氟辛烷磺酸的措施 和增塑剂与上述行为和行为的纵向轨迹相关联 情感结果，以及认知技能。在这两个目标中：环境暴露包括 空气污染、绿地和家居用品的使用；社会因素是邻里环境、家庭 经济困难、种族、民族以及父母的精神健康或药物使用问题。 目标3将高保真地实施最终的回声协议，最大限度地保持并坚持 遵守所有附和政策、IRB、HIPAA和其他法规。UCD将继续提供广泛的捐助 回声基础设施；通过分析和出版物推动科学；促进 通过我们的研究问题、劳动力和留住战略实现多样性和公平性；以及 积极参与并在这一备受瞩目的独特计划中发挥领导作用 儿童健康和发展的潜在风险和复原力因素。

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/co- authored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UCD Aim 1 will: examine environmental, social, and biologic exposures in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and identify both synergistic relationships between environmental and social factors, especially environmental justice and social justice, and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the same exposures, plus measures of PFAS and plasticizers for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. In both aims: environmental exposures include air pollution, greenspace, and home product use; social factors are neighborhood SES, family financial hardship, race, ethnicity, and parental mental health or substance use problems. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UCD will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; promote diversity and equity through our research questions, workforce, and retention strategies; and actively participate & play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.