Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

重温 ReCHARGE:ECHO 对童年中期和青春期的跟进

基本信息

  • 批准号:
    10745252
  • 负责人:
  • 金额:
    $ 123.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/co- authored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UCD Aim 1 will: examine environmental, social, and biologic exposures in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and identify both synergistic relationships between environmental and social factors, especially environmental justice and social justice, and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the same exposures, plus measures of PFAS and plasticizers for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. In both aims: environmental exposures include air pollution, greenspace, and home product use; social factors are neighborhood SES, family financial hardship, race, ethnicity, and parental mental health or substance use problems. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UCD will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; promote diversity and equity through our research questions, workforce, and retention strategies; and actively participate & play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.
从2016年秋季开始,加州大学戴维斯分校(UC Davis)的儿科队列ReCHARGE获得了新基金的资助

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Deborah Hall Bennett其他文献

Deborah Hall Bennett的其他文献

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{{ truncateString('Deborah Hall Bennett', 18)}}的其他基金

The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology
CHARGE 研究第二阶段:自闭症病因学的多因素方法
  • 批准号:
    10153782
  • 财政年份:
    2020
  • 资助金额:
    $ 123.23万
  • 项目类别:
The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology
CHARGE 研究第二阶段:自闭症病因学的多因素方法
  • 批准号:
    10343808
  • 财政年份:
    2020
  • 资助金额:
    $ 123.23万
  • 项目类别:
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES
建造弹珠:弹珠纵向数据共享的生物储存库维护和基础设施
  • 批准号:
    10202600
  • 财政年份:
    2017
  • 资助金额:
    $ 123.23万
  • 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
  • 批准号:
    10240314
  • 财政年份:
    2016
  • 资助金额:
    $ 123.23万
  • 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement
CHARGE 研究儿童的青春期前和青春期后期随访 - 多样性补充
  • 批准号:
    10412853
  • 财政年份:
    2016
  • 资助金额:
    $ 123.23万
  • 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
  • 批准号:
    10675376
  • 财政年份:
    2016
  • 资助金额:
    $ 123.23万
  • 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
  • 批准号:
    10013293
  • 财政年份:
    2016
  • 资助金额:
    $ 123.23万
  • 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
  • 批准号:
    10470815
  • 财政年份:
    2016
  • 资助金额:
    $ 123.23万
  • 项目类别:
Exposure Core
曝光核心
  • 批准号:
    10190947
  • 财政年份:
    2015
  • 资助金额:
    $ 123.23万
  • 项目类别:
Exposure Core
曝光核心
  • 批准号:
    10388389
  • 财政年份:
    2015
  • 资助金额:
    $ 123.23万
  • 项目类别:

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青春期早期饮酒的前瞻性预测因素的鉴定
  • 批准号:
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