Exposure Core

曝光核心

• 批准号: 10190947
• 负责人: Deborah Hall Bennett
• 金额: $ 8.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-05 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10190947
• 关键词: Address; Air Pollutants; Animals; Applications Grants; Benchmarking; Biological; Biometry; Chemicals; Clinic; Collaborations; Communities; Complex; Custom; Data; Data Analyses; Dust; Elements; Engineering; Ensure; Environment; Environmental Epidemiology; Environmental Health; Epidemiologist; Epidemiology; Exposure to; Faculty; Funding; Goals; Grant; Human Milk; Human Resources; Inhalation Toxicology; Isotopes; Laboratories; Leadership; Mass Spectrum Analysis; Measurement; Methods; Modeling; Preparation; Research; Research Design; Research Personnel; Resources; Sampling; Scientist; Seeds; Source; Specific qualifier value; Spectroscopy, Fourier Transform Infrared; System; Techniques; Time; Tissues; Toxicology; Toxin; Wildfire; Work; cost effective; design; environmental justice; environmental toxicology; epidemiology study; exposed human population; exposure pathway; improved; interest; meetings; member; method development; multidisciplinary; particle; portability; programs; recruit; success; synergism

PROJECT SUMMARY – Exposure Core A robust exposure assessment is key to the success of any environmental epidemiology or toxicology project and determining exposure can be complex as people are exposed to multiple compounds through multiple exposure pathways. During the initial funding period, the Exposure Core has become a well-known hub on campus for seeking advice on the exposure related portion of study design and for developing new and helpful methods and facilities to further environmental health research. The Exposure Core has helped connect investigators with analytical laboratories that can help further their exposure characterization, assisted epidemiologists with robust exposure assessment design, and aided toxicologists to quantify exposures and relate them to a relevant benchmark or tissue level. For multi-chemical scenarios, The Core has helped ensure that laboratory exposures model real-world human exposure scenarios. The overarching goal of the Exposure Core is to provide comprehensive exposure study design and analysis expertise to improve the quality of studies that require exposure assessment for epidemiological studies and exposure environments for toxicological studies, and hence improve the quality of environmental health research conducted at UC Davis. Exposure Core laboratories include expertise in: 1) target and non-target analysis of organic compounds in environmental and biological samples, 2) time-integrated or time-window specific exposure concentrations, 3) compositional analysis of environmental samples to identify organic functionality via FTIR and mass spectrometry and elements and isotopes via XRF and ICPMS analysis, 4) design guidance for animal inhalation toxicology studies from a range of air pollutants and sources, 5) resources for helping environmental justice communities determine potential exposures, an exposure vivarium for traffic related airborne particles, and 5) a portable wildfire measurement system. Core members continue to expand the capabilities of their labs to meet these growing needs of center members. The core is increasing our capabilities in helping faculty working with community groups to evaluate compounds of concern and develop streamlined methods for evaluating community exposures. The Exposure Core has developed a program to provide seed funding to investigators for method development to build capabilities. The Exposure Core also provides both subsidies and seed funding for sample analysis in the core laboratories for center members. We provide advice on the study design through Specific Aims Reviews hosted by the Administrative Core, through Exposure Design Reviews for potential pilot applicants, and through meetings with investigators. By providing exposure assessment expertise to investigators as part of an integrated core, rather than via independent campus laboratories, we will be able to provide a much more robust, appropriate, and custom tailored exposure assessment through our synergies, interactions and collaborations.

项目摘要 – Exposure Core 稳健的暴露评估是任何环境流行病学或毒理学项目成功的关键 由于人们通过多种方式接触多种化合物，因此确定暴露量可能很复杂 暴露途径。在最初的融资期间，Exposure Core 已成为知名的中心 校园寻求有关学习设计的接触相关部分的建议以及开发新的和有用的建议 进一步开展环境健康研究的方法和设施。 Exposure Core 帮助连接 拥有分析实验室的研究人员可以帮助进一步确定暴露特征，并协助 流行病学家拥有强大的暴露评估设计，并帮助毒理学家量化暴露和 将它们与相关基准或组织水平联系起来。对于多种化学品场景，The Core 帮助确保 该实验室暴露模拟了真实世界的人类暴露场景。曝光的总体目标 核心是提供全面的暴露研究设计和分析专业知识，以提高暴露研究的质量 需要进行流行病学研究的暴露评估和暴露环境的研究 毒理学研究，从而提高加州大学戴维斯分校进行的环境健康研究的质量。 Exposure Core 实验室包括以下方面的专业知识：1) 有机化合物的目标和非目标分析 环境和生物样品，2) 时间积分或时间窗特定暴露浓度，3) 对环境样品进行成分分析，通过 FTIR 和质量识别有机功能 通过 XRF 和 ICPMS 分析进行光谱测定以及元素和同位素，4) 动物设计指南 来自一系列空气污染物和来源的吸入毒理学研究，5) 帮助环境的资源 司法界确定潜在的暴露，交通相关空气颗粒物的暴露动物园， 5) 便携式野火测量系统。核心成员不断扩展实验室的能力 以满足中心成员不断增长的需求。核心是增强我们帮助教师的能力 与社区团体合作评估关注的化合物并开发简化的方法 评估社区暴露情况。 Exposure Core 制定了一项计划，为以下项目提供种子资金： 研究人员进行方法开发以建立能力。 Exposure Core 还提供两种补贴 为中心成员的核心实验室进行样本分析提供种子资金。我们提供以下方面的建议 通过行政核心主持的具体目标审查进行研究设计，通过暴露设计 对潜在试点申请人进行审查，并通过与调查人员的会议进行审查。通过提供曝光 作为综合核心的一部分，而不是通过独立校园向调查人员提供评估专业知识 实验室，我们将能够提供更强大、更合适和定制的曝光 通过我们的协同作用、互动和合作进行评估。