Exposure Core

项目摘要-曝光核心 强有力的暴露评估是任何环境流行病学或毒理学项目成功的关键。 而确定接触可能很复杂，因为人们通过多种途径接触到多种化合物 暴露途径。在最初的资助期内，Exposure Core已成为 就书房设计中与曝光相关的部分征求意见，并开发新的和有帮助的课程 进一步开展环境健康研究的方法和设施。曝光核心帮助建立了 拥有分析实验室的调查人员可以帮助进一步确定他们的暴露特征，并得到协助 流行病学家具有强大的暴露评估设计，并帮助毒物学家量化暴露和 将它们与相关的基准或组织水平相关联。对于包含多种化学物质的情况，Core帮助确保 该实验室的暴露模拟了真实世界中人类暴露的情景。曝光的首要目标是 核心是提供全面的暴露研究设计和分析专业知识，以提高 需要为流行病学研究和暴露环境进行暴露评估的研究 毒理学研究，从而提高加州大学戴维斯分校进行的环境健康研究的质量。 暴露核心实验室包括以下方面的专业知识：1)目标和非目标有机化合物分析 环境和生物样品，2)时间积分或时间窗特定暴露浓度，3) 通过FTIR和MS对环境样品进行成分分析以鉴定有机功能 通过XRF和ICPMS分析光谱分析和元素及同位素，4)动物设计指南 来自一系列空气污染物和来源的吸入毒理学研究，5)有助于环境保护的资源 司法界确定潜在的暴露量，交通相关空气颗粒物的暴露量， 5)便携式野火测量系统。核心成员继续扩展其实验室的功能 以满足中心成员日益增长的需求。核心是提高我们帮助教职员工的能力 与社区团体合作，评估令人关切的化合物并开发简化的方法 评估社区暴露情况。Exposure Core已经制定了一项计划，为 研究人员为方法开发建立能力。Exposure Core还提供这两项补贴 以及为中心成员的核心实验室的样品分析提供种子资金。我们就以下问题提供建议 通过行政核心主持的特定目标审查进行学习设计，通过展示设计进行 审查潜在的试点申请者，并通过与调查人员的会议。通过提供曝光 将评估专业知识作为综合核心的一部分提供给调查人员，而不是通过独立的园区 实验室，我们将能够提供更强大、更适当和定制的暴露 通过我们的协同效应、互动和协作进行评估。

PROJECT SUMMARY – Exposure Core A robust exposure assessment is key to the success of any environmental epidemiology or toxicology project and determining exposure can be complex as people are exposed to multiple compounds through multiple exposure pathways. During the initial funding period, the Exposure Core has become a well-known hub on campus for seeking advice on the exposure related portion of study design and for developing new and helpful methods and facilities to further environmental health research. The Exposure Core has helped connect investigators with analytical laboratories that can help further their exposure characterization, assisted epidemiologists with robust exposure assessment design, and aided toxicologists to quantify exposures and relate them to a relevant benchmark or tissue level. For multi-chemical scenarios, The Core has helped ensure that laboratory exposures model real-world human exposure scenarios. The overarching goal of the Exposure Core is to provide comprehensive exposure study design and analysis expertise to improve the quality of studies that require exposure assessment for epidemiological studies and exposure environments for toxicological studies, and hence improve the quality of environmental health research conducted at UC Davis. Exposure Core laboratories include expertise in: 1) target and non-target analysis of organic compounds in environmental and biological samples, 2) time-integrated or time-window specific exposure concentrations, 3) compositional analysis of environmental samples to identify organic functionality via FTIR and mass spectrometry and elements and isotopes via XRF and ICPMS analysis, 4) design guidance for animal inhalation toxicology studies from a range of air pollutants and sources, 5) resources for helping environmental justice communities determine potential exposures, an exposure vivarium for traffic related airborne particles, and 5) a portable wildfire measurement system. Core members continue to expand the capabilities of their labs to meet these growing needs of center members. The core is increasing our capabilities in helping faculty working with community groups to evaluate compounds of concern and develop streamlined methods for evaluating community exposures. The Exposure Core has developed a program to provide seed funding to investigators for method development to build capabilities. The Exposure Core also provides both subsidies and seed funding for sample analysis in the core laboratories for center members. We provide advice on the study design through Specific Aims Reviews hosted by the Administrative Core, through Exposure Design Reviews for potential pilot applicants, and through meetings with investigators. By providing exposure assessment expertise to investigators as part of an integrated core, rather than via independent campus laboratories, we will be able to provide a much more robust, appropriate, and custom tailored exposure assessment through our synergies, interactions and collaborations.