Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children

拟议的加州大学戴维斯分校ECHO再充电研究将跟踪一组最后一次看到的2-5岁儿童 年（“基线”），以确定环境化学和非化学压力和复原力 与8-12岁（青春期前）神经发育结局相关的因素 15-19岁（青春期中期至晚期）。该项目利用了CHARGE的资源 （来自基因和环境的儿童自闭症风险）研究，自2003年以来， 三个年龄组2-5岁：自闭症谱系障碍（ASD）儿童，其他 发育迟缓（DD）和一般人群中具有典型发育（TD）的儿童。 将对这三组（ReCHARGE队列）进行以下关注结局检查： 注意力缺陷或多动症状;认知或适应功能的变化; 严重程度或诊断;以及焦虑或抑郁的症状。试点测试将在 UG 3期和UH 3期，所有受试者都将在青春期前或中晚期接受检查 青春期主要的风险是农药，金属，空气污染，邻苯二甲酸盐， 营养、邻里特征和家庭因素。 此外，还提出了三个机制研究：代际调查 表观遗传特征;干血斑中金属分析方法的开发;性别特异性 肾上腺激素与抑郁症状的关系大约1400个家庭符合条件 对于ReCHARGE，为检查主效应、相互作用和中介作用提供了稳健的样本 分析。作为ECHO联盟的一部分，ReCHARGE团队将参与合成 队列结合了来自多个地点的儿童，研究集中在 神经发育协调协议的前瞻性UH 3阶段，并寻求分析 在可行的情况下，合作回顾样本和数据。在UG 3阶段， 研究小组将制定方案，重新接触和招募的试点测试方法， 唾液与血液，以及肾上腺激素研究的实施，包括增加 合规ReCHARGE的独特之处包括有助于理解生命历程 两种不同类型残疾儿童的发展，以及肾上腺皮质激素的新模型 激素与性别特异性情感障碍的关系

The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (‘baseline’) to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.