Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)

波多黎各探索污染威胁的试验场（PROTECT）

• 批准号: 10558677
• 负责人: Akram N Alshawabkeh
• 金额: $ 215.29万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558677
• 关键词: Aromatic Polycyclic Hydrocarbons; Awareness; Back; Behavioral; Biological; Biological Markers; Cellular Phone; Chemical Exposure; Chemicals; Communication; Communities; Data; Data Analyses; Data Management Resources; Data Reporting; Data Set; Development; Disparity population; Engineering; Environment; Environmental Epidemiology; Environmental Pollution; Epidemiology; Event; Exposure to; Floods; Friends; Geography; Goals; Health; Health Care Costs; Human; Hurricane; Individual; Infant Mortality; Infrastructure; Institution; Link; Live Birth; Machine Learning; Mediating; Metals; Methods; Michigan; Modeling; Outcome; Oxidative Stress; Oxidative Stress Pathway; Participant; Pathway interactions; Pesticides; Policies; Population; Pregnant Women; Premature Birth; Public Health Practice; Puerto Rican; Puerto Rico; Reporting; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Support; Risk Reduction; Role; Sampling; Solar Energy; Source; Specimen; Statistical Methods; Structure; Sum; Superfund; System; Technology; Testing; Tissues; Toxicology; Training; US State; Universities; Visualization software; Water; Water Purification; Work; adverse pregnancy outcome; cohort; community engagement; contaminant transport; contaminated drinking water; contaminated water; data management; data mining; data repository; data visualization; drinking water; experience; extreme weather; ground water; health data; human model; human subject; improved; in vitro Model; indexing; innovation; multidimensional data; new technology; novel; phthalates; placental membrane; portability; prenatal; recruit; remediation; social; socioeconomics; sound; superfund chemical; superfund site; tissue culture; toxicant; volatile organic compound; water treatment

PROJECT SUMMARY Evidence suggests that exposure to Superfund chemicals contributes to adverse pregnancy outcomes (APOs), including preterm birth (PTB). Rates of PTB and infant mortality in Puerto Rico (PR) are among the highest of all US states and territories. There are 18 Superfund sites in PR, and evidence of contamination of the drinking water is extensive. Moreover, extreme weather events (hurricanes, flooding) may result in elevated exposures to Superfund chemicals. The PROTECT center has brought together researchers from Northeastern University, the University of Puerto Rico, University of Georgia, and the University of Michigan to provide much needed understanding of the relationship and the mechanisms by which exposure to suspect chemicals contribute to APOs, and to develop new methods to reduce risk of exposure in PR and beyond. To do this, PROTECT uses a source-to-outcome structure, integrating epidemiological (Project 1), toxicological (Project 2), fate and transport (Project 3), and remediation (Project 4) studies, a unified sampling infrastructure, a centralized indexed data repository, and a sophisticated data management system. Since its inception in 2010, PROTECT has built detailed and extensive data sets on environmental conditions and prenatal conditions of 1457 pregnant mothers (exposure, socioeconomic and health data–close to 3000 data points per participant), yielding a cohort of 1210 live births in northern PR. In the renewal, PROTECT will recruit and follow an additional 1000 study participants, yielding a cohort of 800+ live births for an ultimate total cohort of 2000+ completed live births. PROTECT has documented significant contamination of northern PR drinking water and has found compelling preliminary epidemiologic and mechanistic toxicology associations between Superfund chemicals and APOs. PROTECT research has focused on chlorinated volatile organic compounds and phthalates and their role in PTB. The PROTECT renewal will broaden its scope, employing a data-driven approach to study and reduce the impact of exposure to mixtures of suspect chemicals from Superfund sites in karst regions on APOs in Puerto Rico’s underserved, highly-exposed population. Target chemicals will be expanded to include metals, pesticides, and polycyclic aromatic hydrocarbons. We will investigate the impacts of extreme weather events on contaminant transport and exposure, and new water treatment technologies will be developed for portable and robust water treatment systems. The PROTECT renewal will also focus on oxidative stress as an underlying biological pathway by which contaminant exposure can lead to APOs. New statistical methods and data mining, machine learning, and visualization tools will be developed to allow PROTECT researchers to analyze our datasets. PROTECT will employ innovative approaches to engage and educate the community, involve study participants, report- back data, and communicate with stakeholders. A broad suite of training and professional activities will be provided to trainees, individually tailored to the trainees’ needs and goals.

项目概要 有证据表明，接触 Superfund 化学品会导致不良妊娠结局 (APO)， 包括早产（PTB）。波多黎各 (PR) 的 PTB 率和婴儿死亡率是世界上最高的国家之一 美国所有州和地区。波罗的海有18个超级基金站点，有证据表明饮用水受到污染 水源广阔。此外，极端天气事件（飓风、洪水）可能会导致暴露量增加 超级基金化学品。 PROTECT 中心汇集了来自东北大学的研究人员 大学、波多黎各大学、佐治亚大学和密歇根大学提供了很多 需要了解接触可疑化学品的关系和机制 为 APO 做出贡献，并开发新方法来降低 PR 及其他领域的暴露风险。为此， PROTECT 采用源头到结果的结构，整合了流行病学（项目 1）、毒理学（项目 2）、归宿与运输（项目 3）和修复（项目 4）研究、统一抽样基础设施、 集中式索引数据存储库和复杂的数据管理系统。 自 2010 年成立以来，PROTECT 已建立了详细且广泛的环境条件数据集 1457 名孕妇的产前状况（暴露、社会经济和健康数据——接近 3000 每个参与者的数据点），得出了波罗的海北部 1210 名活产婴儿的队列。在更新中，PROTECT 将 招募并跟踪另外 1000 名研究参与者，最终产生 800 多名活产婴儿 2000 多名完成活产的队列。 PROTECT 记录了 PR 北部的严重污染 饮用水，并发现了令人信服的初步流行病学和机械毒理学关联 Superfund 化学品和 APO 之间。 PROTECT 研究重点是氯化挥发性有机物 化合物和邻苯二甲酸盐及其在 PTB 中的作用。 PROTECT 更新将扩大其范围，采用 采用数据驱动的方法来研究和减少接触可疑化学品混合物的影响 来自波多黎各服务欠缺、高度暴露的喀斯特地区超级基金站点 APO 人口。目标化学品将扩大到包括金属、农药和多环芳烃 碳氢化合物。我们将调查极端天气事件对污染物输送和影响 将开发新的水处理技术，以实现便携式和稳健的水处理 系统。 PROTECT 更新还将重点关注氧化应激作为潜在的生物途径 哪些污染物暴露会导致 APO。新的统计方法和数据挖掘、机器学习、 将开发可视化工具，以允许 PROTECT 研究人员分析我们的数据集。保护 将采用创新方法来吸引和教育社区，让研究参与者参与，报告- 返回数据，并与利益相关者进行沟通。一系列广泛的培训和专业活动将 提供给学员，根据学员的需求和目标进行单独定制。