Role of novel VTA neurons in addiction-related behaviors

新型 VTA 神经元在成瘾相关行为中的作用

• 批准号: 10619222
• 负责人: Thomas Hnasko
• 金额: $ 5.59万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2023-02-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619222
• 关键词: Behavior; Behavioral; Disease; Future; Glutamates; Intervention; Neurons; Pharmaceutical Preparations; Population; Process; Psychological reinforcement; Research; Role; addiction; dopaminergic neuron; drug of abuse; motivated behavior; neural circuit; novel; prevent; programs

PROJECT SUMMARY Thveenttreaglmeanrtea(alVTiAsa)corceomponoeftnhtneeurcailrctuhidatrtriygvoe-asdlirebcetheadvior andaprimtaarrygtehtrowuhgihcdhruogfsabusmeodulbaetheavAilotrh.oguegnherraelglayradsaed dopaminneurcglieacubsoh,uatolfVTAneursoingstnharlorueglheoaftsheaeminaocindeurotransmi GABaAngdlutaTmhaetnsee.uraornaeslstoargoefdtrsuogfasbubsuemtuclhesstudRieecde.envtidence froomulraabndothehrasbsegutnoshotwhalti,VkTeADAneuroancst,iivnViTtAGyABAandglutamat neurcoanpnsrofosuhnadmploeytivbaetheadvFiuortsh.esrumbo-rpeo,puolfVaTtAnieounrsroenlsemaosree thaonneofthetsherreeecycling neurtohncsaot-reldeopaasmeaindelutamoarte, transmitters, including glutaamnaGdtAeBAT.hgeoaolftshpirsopoasrtaeoildenhtoiwtfryanscmiot-trefrlreoaVmsTeAcontribut tothperoceusnsdeesrbleyhianvgrieoirnaflonrtac,nehdmoewco-relneeausrifonungnsctiionntaelgilrnyattoe thmeesolinmebuirccailrctuhiratetsgumloattievbaetheadvWieowriu.lslaenarroafgyeneatpipcroaicnhes combinwaittibhoenhaviaonraatlo,maincdealle,ctrophyassisoailynomsgiictceoaslelectpirvoebtlehye connecatnidfvuintcytoifdoinscVrTeAtceircuits.thicsntinruisnegarch cpormopgrriaasmes Together thoropulgathnodeftihnfeoramnfduncotfnioovncellasosfVeTsAneuraonedsnhanocuuernderstand ofhowintrViTnAhseitcerogsehnaepbieetshyaviorstoneuropsydcihsieaatsrei.c relevant

项目摘要 thveenttreaglmeanrtea（alvtiasa）corceomponoeftnhtnhtneeurcailrctuhidatriygvoe-asdlirebcetheadvior andaprimtaarrygtehtrowuhgihgihcdhruogfsabusmeodulbaetheavailotrh.oguegogogegherraelraelglayradsa Dopaminneurcglieacubsoh，uatolfvtaneursoingstnharlorueglheoaftsheeminaocindeurotransmi gabaangdlutatmhaetnsee.uraornaeslstoargoefdtrsuogfasbubsuemtuclhesstudrieecde.envtence froomulraabndothehrasbsegutnoshotwhalti，vkteadaneuroancst，iivnvittagyabaandglutamat neurcoanpnsrofosuhnadmploeytivbaetheadvfiuortsh.esrumbo-rpeo，puolfvattanieounrsroenlsoenlsemaosree thaonneofthetsherreeecycring neurtohncsaot-reldeopaasmeameaseameaseameaseameaseadelatamoarte， 发射器，包括 glutaamnagdtaebat.hgeoaolftshpirsopoasrtaeoildenhtoiwtfryanscmiot-trefrlreoavmstecontribut tothperoceusnsdeesrbleyhianvgrieoirnafronrtac，nehdmoewco-relneeausrifonungnngnsctiionntaelgilrnyattoe thmeesolinmebuirccailrctuhiratetsgumloattievbaetheadvwieowriu.lslaenarrofgyeneatpipcroaicnhes 组合，MainCdealle，ctrophyassisoailynomsgiictCeoAslectpiRectpiRVoebtleHye connecatnidfvuintcytoifdoinscvrteatceircuits.thictinruisnegarch cpormopropraasmes 一起 胸膜刺激性fnfeoramnfduncotfnioovncellasososfvetsaneuraonedsnhanocuuernderstand howIntrvitnahSeitcerogsehnaepbieetShyaviorstoneuropsydcihsieaatsrei.c 相关的

项目成果

Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area.

• DOI: 10.1016/j.celrep.2016.05.057
• 发表时间: 2016-06-21
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Faget L;Osakada F;Duan J;Ressler R;Johnson AB;Proudfoot JA;Yoo JH;Callaway EM;Hnasko TS
• 通讯作者: Hnasko TS

Dietary triglycerides as signaling molecules that influence reward and motivation.

• DOI: 10.1016/j.cobeha.2016.03.005
• 发表时间: 2016-06
• 期刊: Current opinion in behavioral sciences
• 影响因子: 5
• 作者: Berland C;Cansell C;Hnasko TS;Magnan C;Luquet S
• 通讯作者: Luquet S

Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior.

• DOI: 10.1038/mp.2017.7
• 发表时间: 2018-05
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: Hutchison MA;Gu X;Adrover MF;Lee MR;Hnasko TS;Alvarez VA;Lu W
• 通讯作者: Lu W

Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation.

破坏谷氨酸共同传递不会影响多巴胺神经元激活强化的条件行为的获得。

• DOI: 10.1016/j.celrep.2017.02.062
• 发表时间: 2017
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Wang,DongV;Viereckel,Thomas;Zell,Vivien;Konradsson-Geuken,Åsa;Broker,CarlJ;Talishinsky,Aleksandr;Yoo,JiHoon;Galinato,MelissaH;Arvidsson,Emma;Kesner,AndrewJ;Hnasko,ThomasS;Wallén-Mackenzie,Åsa;Ikemoto,Satoshi
• 通讯作者: Ikemoto,Satoshi

Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement.

• DOI: 10.1038/ncomms13697
• 发表时间: 2016-12-15
• 期刊: Nature communications
• 影响因子: 16.6