Biotechnology Training Program

生物技术培训计划

• 批准号: 10620763
• 负责人: Silvia Salinas Blemker
• 金额: $ 53.05万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620763
• 关键词: Biotechnology; Training Programs

PROJECT SUMMARY This application seeks support for UVA's Biotechnology Training Program (BTP). The BTP is a highly interactive, multidisciplinary and >50% diverse community of PhD trainees drawn selectively from an annual May competition open to PhD students from all science and engineering departments university-wide for which we request 10 predoctoral slots. Trainee funding is for 2 years. Our emphasis is on scientific rigor and communication using the latest tools available with award winning and collaborative dual mentoring giving rise to a breadth of multidisciplinary and academic/industrial training unmatched at UVA. Our advocacy for trainee exposure to a wide variety of careers has been transformational - most importantly for trainees but also for the university with which we share many of our offerings. We believe in trainee career preparedness that is personalized, evolving and built on trust, and that relationships do not necessarily end at graduation. Indeed, our graduates welcome the opportunity to return as BTP seminar or industrial panel speakers with talks focused on, or interlaced with, career reflections; or to help in a trainee advisory/advocate role as members of the BTP Board of Corporate Advisors. They are the ultimate measure of our success. Their outcomes are updated at least quarterly on our grads web page with information drawn from LinkedIn. BTP students in training (21, including 11 minorities) or graduated (65) entered with an average undergraduate GPA of 3.7, are currently hosted by 8 different departments. BTP trainees and graduates have received multiple awards, experienced 73 different externships from 51 different companies, and after graduation are now employed in industry (37), academia (15; including an HBCU Dean), government (3), medicine (3), or foundation (2). Since '05, 164 first author articles have been published in journals with impact factors as high as 24. Trainees develop leadership and teamwork skills by taking direct responsibility for programmatic features of the BTP including: BTP Symposia and Seminars, BTP Day of Caring, BTP Industrial Q&A Panels and BTP company tours. Mentoring our trainees is a highly engaged, collaborative and well-funded faculty of 55 individuals from 14 departments. Institutional support has been essential for our success, including Vice President for Research help with externship and Symposia funding, and an additional training slot funded by the School of Engineering. Our overall goal is to develop the next generation of exceptionally rigorous, creative, talented and diverse scientists who are socialized in biotechnology themes and practiced in teamwork. Our aims are to: (1) cement a foundation of rigor in experimental planning, data organization and transparency built on the Nature and eLife recognized 'Open Science Framework' in a collaboration with Charlottesville's 'Center for Open Science', (2) to energetically nurture our trainees love and inquisitiveness for science as they acquire new skills to solve important scientific problems, and (3) to overlay this training with various forms of biotechnology exposure, including required externships – all coupled with a strong and constant commitment to trainee diversity.

项目总结 此应用程序寻求对UVA的生物技术培训计划(BTP)的支持。BTP是一种高度交互、 多学科和50%多样化的博士生社区，从一年一度的5月份竞赛中有选择地挑选出来 向全校所有理工科博士生开放，我们要求10 博士前空位。实习生资助期限为2年。我们的重点是科学严谨和沟通使用 获奖的最新工具和协作式双重指导可带来广泛的 多学科和学术/行业培训是弗吉尼亚大学无与伦比的。我们对实习生接触 各种各样的职业都带来了变革--对实习生来说最重要的是，对大学也是如此 我们分享了我们的许多产品。我们相信实习生的职业准备是个性化的、不断发展的 并建立在信任的基础上，这种关系不一定会在毕业时结束。事实上，我们的毕业生欢迎 有机会以BTP研讨会或工业小组演讲者的身份回来，演讲的重点是或交织在 职业生涯反思；或作为BTP公司董事会成员帮助担任实习生顾问/倡导者角色 顾问。它们是衡量我们成功的终极标准。他们的结果至少每季度更新一次 毕业生网页上的信息来自LinkedIn。正在接受培训的BTP学生(21名，包括11名少数族裔)或 毕业(65人)，平均本科生GPA为3.7，目前由8个不同的 各部门。BTP学员和毕业生获得多个奖项，经历了73种不同的外部奖学金 来自51家不同的公司，毕业后现在受雇于工业(37家)、学术界(15家；包括 HBCU院长)、政府(3)、医药(3)或基金会(2)。自05年以来，已有164篇第一作者文章 发表在影响因子高达24的期刊上。学员通过以下方式培养领导力和团队合作能力 直接负责BTP的方案功能，包括：BTP研讨会和研讨会、BTP 关爱之日，BTP工业问答小组和BTP公司之旅。指导我们的实习生是一项高度投入的工作， 由来自14个部门的55名个人组成的协作和资金充足的教职员工。机构支持一直是 对我们的成功至关重要，包括负责研究的副总裁帮助外部奖学金和研讨会资金，以及 一个由工程学院资助的额外培训时段。我们的总体目标是发展下一代 非常严谨、富有创造力、才华横溢、多样化的科学家，他们对生物技术主题了如指掌 并在团队合作中练习。我们的目标是：(1)在实验计划、数据方面巩固严谨的基础 组织和透明度建立在自然和eLife认可的在一个 与夏洛茨维尔开放科学中心合作，(2)大力培养学员的爱心和 对科学的好奇心，因为他们获得了解决重要科学问题的新技能，以及(3)覆盖 这项培训包括各种形式的生物技术接触，包括所需的外部培训-所有这些都伴随着 坚定不移地致力于学员的多样性。

项目成果

Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity.

• DOI: 10.1007/s11306-022-01904-9
• 发表时间: 2022-07-11
• 期刊: METABOLOMICS
• 影响因子: 3.6
• 作者: Dillard, L. R.;Wase, N.;Ramakrishnan, G.;Park, J. J.;Sherman, N. E.;Carpenter, R.;Young, M.;Donlan, A. N.;Petri, W.;Papin, J. A.
• 通讯作者: Papin, J. A.

Controlling scaffold conductivity and pore size to direct myogenic cell alignment and differentiation.

• DOI: 10.1002/jbm.a.37418
• 发表时间: 2022-10
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Basurto, Ivan M.;Muhammad, Samir A.;Gardner, Gregg M.;Christ, George J.;Caliari, Steven R.
• 通讯作者: Caliari, Steven R.

Peptide Stereocomplexation Orchestrates Supramolecular Assembly of Hydrogel Biomaterials

• DOI: 10.1021/jacs.3c04872
• 发表时间: 2023-08-11
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Duti, Israt Jahan;Florian, Jonathan R.;Letteri, Rachel A.
• 通讯作者: Letteri, Rachel A.

Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry.

通过单细胞质量流式细胞仪的蛋白质表达谱鉴定新生小鼠背根神经节的性别二态性。

• DOI: 10.1016/j.mcn.2023.103866
• 发表时间: 2023
• 期刊: Molecular and cellular neurosciences
• 作者: Vradenburgh,ShaylaA;VanDeusen,AmyL;Beachum,AllisonN;Moats,JacquelineM;Hirt,AshleyK;Deppmann,ChristopherD;Keeler,AustinB;Zunder,EliR
• 通讯作者: Zunder,EliR

A genetically-encoded biosensor for direct detection of perfluorooctanoic acid.

• DOI: 10.1038/s41598-023-41953-1
• 发表时间: 2023-09-13
• 期刊: Scientific reports
• 影响因子: 4.6