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Aversive Information Processing Biases in Nicotine Dependence

尼古丁依赖中的厌恶性信息处理偏差

基本信息

批准号：
10626712
负责人：
Brian August Anderson
金额：
$ 18.37万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626712
关键词：
Accounting Address Adverse effects Affect Attention Chemicals Cigarette Clinical Assessment Tool Cognitive Cues Data Dependence Detection Drug usage Electronic Nicotine Delivery Systems Exhibits Exposure to Eye Movements Foundations Goals Habits Health Image Individual Knowledge Learning Link Literature Maintenance Measures Mediating Modification Negative Reinforcements Nicotine Nicotine Dependence Outcome Pattern Persons Pharmaceutical Preparations Play Population Predisposition Process Public Health Punishment Relapse Research Resistance Rewards Role Sampling Shapes Shock Signal Transduction Smoking Stimulus Substance Addiction System Techniques Testing Time Tobacco Toxin United States addiction adverse outcome attentional bias attentional control aversive conditioning behavior influence cigarette smoking craving effective therapy electronic cigarette use electronic cigarette user experience falls improved information processing insight interest novel novel strategies programs prolonged abstinence relapse prevention sensory input young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The use of electronic nicotine delivery systems (ENDS) is on the rise, particularly among young people, and has been linked to nicotine dependence. Abuse of ENDS is associated with a variety of adverse consequences, but as is frequently observed with substance dependence, these adverse consequences are often insufficient to motivate and sustain quitting attempts. Nicotine dependence remains a significant public health burden. New approaches to facilitate quitting and sustain abstinence are needed, which will require novel insights into why a nicotine addiction remains so difficult to overcome. Attention has long been understood to play an important role in the addiction process, including nicotine addiction. Attention selects which aspects of sensory input receive cognitive processing and thereby influence behavior. A substantial body of research has been devoted to investigating the mechanisms by which smoking-related cues draw attention through reward-mediated processes and the degree to which these biases predict quitting, along with developing attentional bias modification techniques intended to facilitate quitting. These efforts have been largely unsuccessful and therefore appear to fall short of accounting for the full range of information processing biases responsible for the maintenance of a nicotine addiction. In the pursuit of a more comprehensive account of these biases, the influence of aversive outcomes on attention offers promise. Interest in how aversive outcomes influence the control of attention has grown in recent years, and robust biases towards aversively- conditioned stimuli have been identified in non-clinical samples. However, how aversive conditioning influences attention in the context of addiction remains unexplored. This is especially pertinent to the issue of why individuals often maintain an addiction in spite of repeated exposure to its harmful effects. To address this gap in understanding, the proposed research seeks to identify how nicotine-dependent ENDS users and non-users differ with respect to the manner in which their attention systems are influenced by aversive outcomes. In Specific Aim 1, attentional biases towards aversively conditioned stimuli in ENDS users and matched non- users will be measured, probing the strength of threat-related attentional biases. In Specific Aim 2, differences between users and non-users with respect to the relative influences of threat detection and negative reinforcement on the control of attention will be examined, which together with Specific Aim 1 will provide a comprehensive picture of whether and how aversive information processing differs between ENDS users and non-users. The overarching goal of the proposed research is to more fully characterize how biases in the orienting of attention are related to nicotine addiction, offering unique insights into why users are often undeterred by the adverse effects of their habit. Knowledge gained from the proposed research could provide a foundation for more effective treatments, quitting programs, and clinical assessment tools.

项目总结/文摘