T32 Research Training Program in ImmunoEngineering

摘要 随着近几十年来免疫学和免疫治疗领域的蓬勃发展， 免疫学研究和临床中的药品、生物医学设备和生物材料 应用领域迅速扩大。因此，对训练有素的工程师的需求越来越大 开发有效的免疫疗法和翻译这些发展所需的量化技能 为工业干杯。免疫学是一门基础科学，有许多需要积极转化的应用。 影响病人的生活。大多数在免疫工程领域工作的公司都雇佣了基础科学家，因为 免疫学是一门基础科学，尽管它有许多可以翻译的应用程序，以便 积极影响患者的生活(例如，抗炎或免疫抑制药物，避免移植 排斥、用于癌症治疗的采用细胞疗法)。然而，这些人没有接受过 既不是工程学，也不是定量或系统观点。相比之下，工程师也被雇佣到以下公司 在免疫工程领域工作，但他们往往没有接受过免疫学培训。博士前培训 本申请中描述的计划旨在通过对工程师进行免疫学(AS)培训来更好地装备他们 在工程方面也是如此)。要求每年资助四名受训人员，为期五年。通过这件事 免疫工程培训计划，正在开发一种新型的工程学博士生，一名 能够应用具有免疫学知识的工程原理，对新的治疗方法产生影响 谁将填补进入当今劳动力大军的现有生物工程师的关键空白。这次培训 该计划还将提供转化医学和道德培训，使受训者掌握重要的 “软技能”，如项目和时间管理、道德和对翻译方面的理解 将产品推向市场。

Abstract With the burgeoning of the fields of immunology and immunotherapy in the last few decades, the use of pharmaceutical products, biomedical devices, and biomaterials in immunological research and clinical applications has rapidly expanded. Accordingly, there has been an increasing need for engineers trained with the quantitative skills necessary for developing effective immunotherapies and translating these developments to industry. Immunology is a basic science that has a lot of applications that need to be translated to positively impact patients' lives. Most companies working in this area of ImmunoEngineering hire basic scientists since immunology is a basic science, albeit one that has a lot of applications amenable to translation in order to positively impact patients' lives (e.g. anti-inflammatory or immunosuppressive drugs, avoiding transplant rejection, adoptive cell therapy for cancer treatment). However, these individuals do not have training in engineering nor quantitative or systems perspectives. In contrast, engineers are also hired into companies that work in ImmunoEngineering areas, but often they do not have immunology training. The pre-doctoral training program described in this application is aimed to better equip engineers by training them in immunology (as well as in engineering). Funding for four trainees per year is requested for five years. Through this ImmunoEngineering training program, a new type of engineering doctoral trainee is being developed, one who can apply engineering principles with knowledge of immunology to make impacts on new treatments for disease and who will fill a critical gap in existing bioengineers entering today's work force. This training program will furthermore provide translational medicine and ethics training to equip trainees with important “soft skills” such as project and time management, ethics and understanding of the translational aspects of bring a product to market.