T32 Research Training Program in ImmunoEngineering

T32 免疫工程研究培训项目

• 批准号: 10628939
• 负责人: JULIA E BABENSEE
• 金额: $ 21.69万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628939
• 关键词: Research Training; Training Programs; immunoengineering

Abstract With the burgeoning of the fields of immunology and immunotherapy in the last few decades, the use of pharmaceutical products, biomedical devices, and biomaterials in immunological research and clinical applications has rapidly expanded. Accordingly, there has been an increasing need for engineers trained with the quantitative skills necessary for developing effective immunotherapies and translating these developments to industry. Immunology is a basic science that has a lot of applications that need to be translated to positively impact patients' lives. Most companies working in this area of ImmunoEngineering hire basic scientists since immunology is a basic science, albeit one that has a lot of applications amenable to translation in order to positively impact patients' lives (e.g. anti-inflammatory or immunosuppressive drugs, avoiding transplant rejection, adoptive cell therapy for cancer treatment). However, these individuals do not have training in engineering nor quantitative or systems perspectives. In contrast, engineers are also hired into companies that work in ImmunoEngineering areas, but often they do not have immunology training. The pre-doctoral training program described in this application is aimed to better equip engineers by training them in immunology (as well as in engineering). Funding for four trainees per year is requested for five years. Through this ImmunoEngineering training program, a new type of engineering doctoral trainee is being developed, one who can apply engineering principles with knowledge of immunology to make impacts on new treatments for disease and who will fill a critical gap in existing bioengineers entering today's work force. This training program will furthermore provide translational medicine and ethics training to equip trainees with important “soft skills” such as project and time management, ethics and understanding of the translational aspects of bring a product to market.

摘要 随着免疫学和免疫治疗领域在过去几十年中的蓬勃发展， 免疫学研究和临床应用中的医药产品、生物医学设备和生物材料 应用迅速扩大。因此，越来越需要受过培训的工程师， 开发有效的免疫疗法和转化这些发展所需的定量技能 到工业。免疫学是一门基础科学，有很多应用需要积极转化 影响患者的生活。大多数从事免疫工程领域工作的公司都雇佣基础科学家， 免疫学是一门基础科学，尽管它有很多可以翻译的应用， 对患者的生活产生积极影响（例如，抗炎或免疫抑制药物，避免移植 排斥、用于癌症治疗的过继细胞疗法）。然而，这些人没有接受过以下方面的培训： 工程或定量或系统观点。相比之下，工程师也被雇用到公司， 在免疫工程领域工作，但他们通常没有免疫学培训。博士前培训 本申请中描述的程序旨在通过在免疫学方面对工程师进行培训来更好地装备他们（如 在工程方面）。要求在五年内每年资助四名受训人员。通过这个 免疫工程培训项目，正在开发一种新型的工程博士生， 可以应用工程原理与免疫学知识，使新的治疗方法的影响， 疾病和世卫组织将填补现有生物工程师进入今天的劳动力的关键缺口。本次培训 该计划还将提供转化医学和伦理培训，使学员具备重要的 “软技能”，如项目和时间管理，道德和翻译方面的理解 把产品推向市场。

项目成果

Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia.

• DOI: 10.1021/acscombsci.0c00081
• 发表时间: 2020-10-12
• 期刊: ACS combinatorial science
• 作者: Do P;Perdue LA;Chyong A;Hunter R;Dougan J;Henry CJ;Porter CC;Dreaden EC
• 通讯作者: Dreaden EC

Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines.

• DOI: 10.1021/acs.biomac.2c01207
• 发表时间: 2023-03-13
• 期刊: BIOMACROMOLECULES
• 影响因子: 6.2
• 作者: Birnbaum, Lacey A.;Sullivan, Emily C.;Do, Priscilla;Uricoli, Biaggio;Raikar, Sunil S.;Porter, Christopher C.;Henry, Curtis J.;Dreaden, Erik C.
• 通讯作者: Dreaden, Erik C.