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Identifying LC3 binders to develop lysosome-targeting chimeras

Identifying LC3 binders to develop lysosome-targeting chimeras
鉴定 LC3 结合物以开发溶酶体靶向嵌合体
批准号：
10916067
负责人：
Mark Henderson
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916067
关键词：
Adaptor Signaling ProteinAutomobile DrivingAutophagocytosisAutophagosomeBasic ScienceBindingBinding SitesBiological AssayCellsChimera organismComplementHealthHomeostasisHumanHuman GenomeLysosomesNational Center for Advancing Translational SciencesPathway interactionsProtacRare DiseasesRecyclingReporterReportingResearchStressTranslationsdesigndrug candidatehigh throughput screeningimprovedinterestnovelpharmacologicprogramsreceptorsmall moleculetoolvirtual screening

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中文摘要
翻译
NCATS早期翻译处(ETB)主持了一项广泛而全面的计划，以发现针对罕见疾病的候选药物和探索人类基因组功能的药理学工具。ETB进行研究，以了解推动基础研究发现转化为对人类健康的切实改善的潜在原则。 在本报告所述期间，项目组开发和优化了一种高通量筛选试验，以利用报告构建物检测LC3结合物。高通量筛选正在进行中，同时进行虚拟筛选以确定适合LIR结合位点的小分子。
英文摘要
The NCATS Early Translation Branch (ETB) hosts a broad and comprehensive program for the discovery of drug candidates directed towards rare diseases and pharmacological tools to probe the function of the human genome. ETB conducts research to understand the underlying principles driving the translation of basic research discoveries into tangible improvements in human health. During this reporting period, the project team has developed and optimized a high-throughput screening assay to detect LC3 binders utilizing a reporter construct. High-throughput screening is underway, while virtual screening was performed to identify small molecules that fit into the LIR-binding site within LC3.
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