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Identifying LC3 binders to develop lysosome-targeting chimeras

Identifying LC3 binders to develop lysosome-targeting chimeras
鉴定 LC3 结合物以开发溶酶体靶向嵌合体
批准号：
10916067
负责人：
Mark Henderson
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916067
关键词：
Adaptor Signaling ProteinAutomobile DrivingAutophagocytosisAutophagosomeBasic ScienceBindingBinding SitesBiological AssayCellsChimera organismComplementHealthHomeostasisHumanHuman GenomeLysosomesNational Center for Advancing Translational SciencesPathway interactionsProtacRare DiseasesRecyclingReporterReportingResearchStressTranslationsdesigndrug candidatehigh throughput screeningimprovedinterestnovelpharmacologicprogramsreceptorsmall moleculetoolvirtual screening

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英文摘要
The NCATS Early Translation Branch (ETB) hosts a broad and comprehensive program for the discovery of drug candidates directed towards rare diseases and pharmacological tools to probe the function of the human genome. ETB conducts research to understand the underlying principles driving the translation of basic research discoveries into tangible improvements in human health. During this reporting period, the project team has developed and optimized a high-throughput screening assay to detect LC3 binders utilizing a reporter construct. High-throughput screening is underway, while virtual screening was performed to identify small molecules that fit into the LIR-binding site within LC3.
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