CSHL Conference on Molecular and Cellular Biology of Plasminogen Activation

描述（由申请人提供）： 一般而言，蛋白水解调节，特别是纤溶酶原激活，是科学研究、临床医学和生物技术界面上快速发展的领域。第十二届纤溶酶原激活的分子和细胞生物学国际研讨会将于2009年3月31日至4月4日在冷泉港，纽约举行。这一两年期会议已成为自由交流信息的一个主要论坛，其范围超出了在更正式的会议上发表和介绍的范围。该研讨会的独特之处在于科学计划完全是抽象驱动的。因此，所有的介绍都是从提交的摘要中选出的。此外，还强调让年轻的调查员和受训人员参加每一次培训。摘要将根据科学价值进行评分，然后组织成一个简短的谈话和海报的最终计划。该计划将容纳大约50个短（10-15分钟）的口头报告。初级研究人员预计将占与会者的30-40%。主席和近一半的预计讨论领导人都是妇女。将讨论的主题包括纤溶酶原激活剂和相关蛋白的结构和功能，以及纤溶酶原激活系统在心血管生物学，神经生物学，肿瘤生物学，组织重塑和修复，感染和宿主防御中的新发现的作用。此外，我们将增加新的会议设计考虑纤溶酶/纤溶酶原激活剂-基质金属蛋白酶接口。新的会议也将致力于不断增长的名单最近发现的丝氨酸蛋白酶和膜相关蛋白酶。最后，该计划将包括一个会议，每个会议的高通量基因组和蛋白质组学工具的蛋白酶生物学和蛋白酶靶向治疗的目的。冷泉港实验室会议设施靠近纽约机场，提供最先进的视听设施、舒适的住宿和出色的餐饮服务。由于本次会议的摘要性质，所介绍的材料大部分未发表，因此与其他相关会议的重叠极少。

DESCRIPTION (provided by applicant): Proteolytic regulation, in general, and plasminogen activation in particular, are rapidly advancing fields at the interface of scientific research, clinical medicine, and biotechnology. The XIIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation will meet in Cold Spring Harbor, New York from March 31 - April 4, 2009. This biennial meeting has become a major forum for the free exchange of information beyond that achieved by publication and presentation at more formal meetings. The Workshop is unique in that the scientific program is entirely abstract-driven. Thus, all of the presentations are selected from submitted abstracts. In addition, emphasis is placed upon involving young investigators and trainees to participate in each session. Abstracts will be scored according to scientific merit, and then organized into a final program of short talks and posters. The program will accommodate approximately 50 short (10-15 min) oral presentations. Junior investigators are expected to constitute 30-40% of attendees. Both chairpersons and nearly half of the projected discussion leaders are women. Topics to be discussed will include the structure and function of plasminogen activators and related proteins, and the newly discovered roles of the plasminogen activation system in cardiovascular biology, neurobiology, tumor biology, tissue remodeling and repair, infection, and host defense. In addition, we will add new sessions designed to consider the plasmin/plasminogen activator-matrix metalloproteinase interface. Also new will be sessions devoted to the growing list of recently discovered serine proteases and membraneassociated proteases. Finally, the program will encompass one session each on high throughput genomic and proteomic tools for protease biology and on protease targeting for therapeutic purposes. The Cold Spring Harbor Laboratory Conference Facility provides proximity to the New York airports, state-of-the-art audio-visual facilities, comfortable housing, and outstanding meal services. Because of the abstract-driven nature of this meeting, the material presented is largely unpublished, and therefore overlaps minimally with other related meetings.