Race-based social stress and health trajectories from adolescence to adulthood

从青春期到成年基于种族的社会压力和健康轨迹

• 批准号: 7852943
• 负责人: JACQUELYNNE S ECCLES
• 金额: $ 49.61万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7852943
• 关键词: Acute; Adolescence; Adolescent; Adolescent Development; African American; Age; Aging; Aging-Related Process; American; Anti-Inflammatory Agents; Anti-inflammatory; Arts; Autonomic nervous system; Behavior; Behavioral; Belief; Bioinformatics; Biological; Biological Markers; Biological Process; Cardiovascular system; Cells; Chronic Disease; Classification; Collection; Complement; Data; Data Collection; Development; Discrimination; Disease; Endocrine system; Ethnic Origin; European; Exposure to; Family; Feeling; Future; Gene Expression Profiling; Genes; Glucocorticoid Receptor; Glucocorticoids; Goals; Grant; Health; Home environment; IL6 gene; Immune; Individual; Inflammation; Inflammatory; Laboratories; Leukocytes; Longitudinal Studies; Maryland; Measurement; Measures; Mediating; Metabolic; Methods; Modeling; NF-kappa B; Neighborhoods; Occupational; Oral mucous membrane structure; Outcome; Parents; Participant; Pathway interactions; Pattern; Physiological; Plasma; Process; Production; Prospective Studies; Protocols documentation; Psyche structure; Psychophysiology; Public Health; Race; Recording of previous events; Recovery; Research Personnel; Resistance; Risk Factors; Sampling; Schools; Sleep; Socialization; Stress; System; Techniques; Transcriptional Regulation; Translating; Transudate; Tumor Necrosis Factor-alpha; Validation; Variant; Work; base; biological systems; cytokine; desensitization; diaries; ethnic discrimination; health disparity; healthy aging; human TNF protein; hypothalamic-pituitary-adrenal axis; peer influence; person centered; physical conditioning; psychologic; psychosocial; public health relevance; racial and ethnic; response; social; social stress; stressor; young adult

DESCRIPTION (provided by applicant): The broad aim of this Grand Opportunity Grant is to understand how race-based social stress, racial/ethnic (R/E) identity, and biological functioning contribute to health and healthy aging. Using the Maryland Adolescent Development in Context Study (MADICS) we propose to complement existing psychosocial, mental, and physical health data with the collection of a comprehensive set of measures of biological systems intimately tied to health and disease and highly relevant to the aging processes. MADICS is a nationally-recognized 17- year longitudinal study of family, school, neighborhood, and peer influences on the healthy and successful development of an initial sample of 1482 early adolescents and their families (60% African American, 35% European American, and similar proportions of "middle class" SES within these groups). Measures gathered across seven waves of data collection (ages 12 to 30) include histories of perceived discrimination based on race/ethnicity; beliefs, behaviors, and feelings about one's perceived R/E classification (i.e., R/E identity); mental and physical health; and psychosocial functioning (e.g., educational and occupational attainment). Here we propose to add a wide range of measures of biological systems associated with health and disease and highly relevant to the prospective study of aging processes. The primary goal is to explore how developmental histories of discrimination contribute to the pre-disease and health states of approximately 300 young adults (approximately 32 years old) and the extent to which these relations vary by R/E classification, SES, and R/E identity. Specifically, we will assess (1) the basal functioning of multiple physiological systems (endocrine, cardiovascular, metabolic, immune, inflammatory, sleep) reflecting well-established risk factors for a variety of poor health outcomes; (2) the acute reactivity and recovery of three physiological response systems tied to the development of chronic disease (i.e., hypothalamic-pituitary-adrenal [HPA] axis, autonomic nervous system, inflammatory system) in the context of a daily diary study and also in an experimental setting in which we expose individuals to a discriminatory episode; (3) inflammatory cytokine production and immune cell resistance to the anti-inflammatory effects of glucocorticoids, gene expression profiling of leukocytes to identify broad groups of genes associated with social stress (e.g., inflammation-related genes), and bioinformatic analyses to identify transcriptional control pathways that might potentially mediate these effects; and (4) person-centered health trajectory profiles constructed from mental and physical health and the proposed biomarkers and the extent to which their relations to histories of discrimination are moderated by R/E classification, SES, R/E identity, and parent socialization factors. An additional aim of this grant is to develop methods that can become part of the toolkit of future field-based health and aging researchers (e.g., validation of the measurement of TNF-alpha and IL6 in Oral Mucosal Transudate and the development of a field-friendly stress reactivity protocol that can be conducted in a mobile psychophysiological van). PUBLIC HEALTH RELEVANCE: Disparities in health associated with racial/ethnic classification persist in the US. The elimination of such health disparities is of paramount importance for public health. Understanding factors associated with health disparities is critical for their elimination. This application includes studies that focus on better understanding the biological, psychological, and social factors that contribute to health disparities.

描述（由申请人提供）：这个大机会补助金的广泛目标是了解如何基于种族的社会压力，种族/民族（R/E）的身份和生物功能有助于健康和健康老龄化。使用马里兰州青少年发展的背景下的研究（MADICS），我们建议补充现有的心理，心理和身体健康的数据与收集的一套全面的生物系统的措施密切相关的健康和疾病和高度相关的衰老过程。MADICS是一项全国公认的17年纵向研究，研究家庭、学校、社区和同龄人对1482名早期青少年及其家庭（60%非裔美国人，35%欧洲裔美国人，这些群体中“中产阶级”SES的比例相似）健康和成功发展的影响。在七波数据收集（12至30岁）中收集的测量包括基于种族/民族的感知歧视的历史;关于一个人感知的R/E分类的信念，行为和感受（即，R/E身份）;心理和身体健康;和心理社会功能（例如，教育和职业成就）。在这里，我们建议增加一个广泛的措施与健康和疾病相关的生物系统和高度相关的前瞻性研究的衰老过程。主要目标是探索歧视的发展历史如何有助于约300名年轻人（约32岁）的疾病前和健康状态，以及这些关系在多大程度上因R/E分类，SES和R/E身份而异。具体而言，我们将评估（1）多个生理系统（内分泌、心血管、代谢、免疫、炎症、睡眠）的基础功能，反映各种不良健康结果的既定风险因素;（2）与慢性疾病发展相关的三个生理反应系统的急性反应性和恢复（即，下丘脑-垂体-肾上腺[HPA]轴，自主神经系统，炎症系统）的背景下，每天的日记研究，也在实验设置中，我们暴露个人的歧视事件;（3）炎性细胞因子产生和免疫细胞对糖皮质激素抗炎作用的抗性，白细胞的基因表达谱以鉴定与社会压力相关的广泛基因组（例如，炎症相关基因），以及生物信息学分析，以确定可能潜在介导这些影响的转录控制途径;以及（4）以人为中心的健康轨迹概况，该健康轨迹概况由精神和身体健康以及所提出的生物标志物构建，以及它们与歧视历史的关系在多大程度上受到R/E分类、SES、R/E身份和父母社会化因素的调节。这项赠款的另一个目的是开发可以成为未来实地健康和老龄化研究人员工具包的一部分的方法（例如，口腔粘液渗出液中TNF-α和IL-6测量的验证和可在移动的心理生理学货车中进行的现场友好应激反应方案的开发）。 公共卫生相关性：在美国，与种族/民族分类相关的健康差异持续存在。消除这种健康差距对公共卫生至关重要。了解与健康差距相关的因素对于消除这些差距至关重要。该应用程序包括专注于更好地了解导致健康差异的生物，心理和社会因素的研究。