Race-based social stress and health trajectories from adolescence to adulthood

从青春期到成年基于种族的社会压力和健康轨迹

• 批准号: 7942989
• 负责人: JACQUELYNNE S ECCLES
• 金额: $ 40.42万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942989
• 关键词: Acute; Adolescence; Adolescent; Adolescent Development; Adult; African American; Age; Aging; Aging-Related Process; American; Anti-Inflammatory Agents; Anti-inflammatory; Arts; Autonomic nervous system; Behavior; Behavioral; Belief; Bioinformatics; Biological; Biological Markers; Biological Process; Cardiovascular system; Cells; Chronic Disease; Classification; Collection; Complement; Data; Data Collection; Development; Discrimination; Disease; Endocrine system; Ethnic Origin; European; Exposure to; Family; Feeling; Future; Gene Expression Profiling; Genes; Glucocorticoid Receptor; Glucocorticoids; Goals; Grant; Health; Home environment; IL6 gene; Immune; Individual; Inflammation; Inflammatory; Laboratories; Leukocytes; Longitudinal Studies; Maryland; Measurement; Measures; Mediating; Metabolic; Methods; Modeling; NF-kappa B; Neighborhoods; Occupational; Oral mucous membrane structure; Outcome; Parents; Participant; Pathway interactions; Pattern; Physiological; Plasma; Process; Production; Prospective Studies; Protocols documentation; Psyche structure; Psychophysiology; Public Health; Race; Recording of previous events; Recovery; Research Personnel; Resistance; Risk Factors; Sampling; Schools; Sleep; Socialization; Stress; System; Techniques; Transcriptional Regulation; Translating; Transudate; Tumor Necrosis Factor-alpha; Validation; Variant; Work; base; biological systems; cytokine; desensitization; diaries; ethnic discrimination; health disparity; healthy aging; human TNF protein; hypothalamic-pituitary-adrenal axis; peer influence; person centered; physical conditioning; psychologic; psychosocial; public health relevance; racial and ethnic; response; social; social stress; stressor; young adult

DESCRIPTION (provided by applicant): The broad aim of this Grand Opportunity Grant is to understand how race-based social stress, racial/ethnic (R/E) identity, and biological functioning contribute to health and healthy aging. Using the Maryland Adolescent Development in Context Study (MADICS) we propose to complement existing psychosocial, mental, and physical health data with the collection of a comprehensive set of measures of biological systems intimately tied to health and disease and highly relevant to the aging processes. MADICS is a nationally-recognized 17- year longitudinal study of family, school, neighborhood, and peer influences on the healthy and successful development of an initial sample of 1482 early adolescents and their families (60% African American, 35% European American, and similar proportions of "middle class" SES within these groups). Measures gathered across seven waves of data collection (ages 12 to 30) include histories of perceived discrimination based on race/ethnicity; beliefs, behaviors, and feelings about one's perceived R/E classification (i.e., R/E identity); mental and physical health; and psychosocial functioning (e.g., educational and occupational attainment). Here we propose to add a wide range of measures of biological systems associated with health and disease and highly relevant to the prospective study of aging processes. The primary goal is to explore how developmental histories of discrimination contribute to the pre-disease and health states of approximately 300 young adults (approximately 32 years old) and the extent to which these relations vary by R/E classification, SES, and R/E identity. Specifically, we will assess (1) the basal functioning of multiple physiological systems (endocrine, cardiovascular, metabolic, immune, inflammatory, sleep) reflecting well-established risk factors for a variety of poor health outcomes; (2) the acute reactivity and recovery of three physiological response systems tied to the development of chronic disease (i.e., hypothalamic-pituitary-adrenal [HPA] axis, autonomic nervous system, inflammatory system) in the context of a daily diary study and also in an experimental setting in which we expose individuals to a discriminatory episode; (3) inflammatory cytokine production and immune cell resistance to the anti-inflammatory effects of glucocorticoids, gene expression profiling of leukocytes to identify broad groups of genes associated with social stress (e.g., inflammation-related genes), and bioinformatic analyses to identify transcriptional control pathways that might potentially mediate these effects; and (4) person-centered health trajectory profiles constructed from mental and physical health and the proposed biomarkers and the extent to which their relations to histories of discrimination are moderated by R/E classification, SES, R/E identity, and parent socialization factors. An additional aim of this grant is to develop methods that can become part of the toolkit of future field-based health and aging researchers (e.g., validation of the measurement of TNF-alpha and IL6 in Oral Mucosal Transudate and the development of a field-friendly stress reactivity protocol that can be conducted in a mobile psychophysiological van). PUBLIC HEALTH RELEVANCE: Disparities in health associated with racial/ethnic classification persist in the US. The elimination of such health disparities is of paramount importance for public health. Understanding factors associated with health disparities is critical for their elimination. This application includes studies that focus on better understanding the biological, psychological, and social factors that contribute to health disparities.

描述（由申请人提供）：这项大机会补助金的主要目标是了解基于种族的社会压力、种族/民族 (R/E) 身份和生物功能如何促进健康和健康老龄化。利用马里兰州青少年发展背景研究（MADICS），我们建议通过收集与健康和疾病密切相关且与衰老过程高度相关的生物系统的一套全面的测量数据来补充现有的社会心理、精神和身体健康数据。 MADICS 是一项全国公认的为期 17 年的纵向研究，研究了家庭、学校、邻里和同伴对 1482 名早期青少年及其家庭（60% 为非洲裔美国人，35% 为欧洲裔美国人，以及这些群体中比例相似的“中产阶级”SES）的初始样本的健康和成功发展的影响。通过七波数据收集（12 至 30 岁）收集的衡量标准包括基于种族/民族的感知歧视的历史；关于一个人所感知的 R/E 分类（​​即 R/E 身份）的信念、行为和感受；心理和身体健康；和心理社会功能（例如，教育和职业成就）。在这里，我们建议添加与健康和疾病相关且与衰老过程的前瞻性研究高度相关的生物系统的广泛测量。主要目标是探索歧视的发展史如何影响约 300 名年轻人（约 32 岁）的病前和健康状态，以及这些关系因 R/E 分类、SES 和 R/E 身份而变化的程度。具体来说，我们将评估（1）多个生理系统（内分泌、心血管、代谢、免疫、炎症、睡眠）的基础功能，反映各种不良健康结果的既定风险因素； （2）在日常日记研究的背景下以及在我们将个体暴露于歧视事件的实验环境中，与慢性疾病的发展相关的三个生理反应系统（即下丘脑-垂体-肾上腺[HPA]轴、自主神经系统、炎症系统）的急性反应和恢复； (3) 炎症细胞因子的产生和免疫细胞对糖皮质激素抗炎作用的抵抗，白细胞的基因表达谱以确定与社会压力相关的广泛基因（例如炎症相关基因），以及生物信息学分析以确定可能介导这些影响的转录控制途径； (4) 以人为中心的健康轨迹档案，由心理和身体健康以及拟议的生物标志物构建，以及它们与歧视历史的关系在多大程度上受到 R/E 分类、SES、R/E 身份和父母社会化因素的调节。这笔赠款的另一个目的是开发可以成为未来现场健康和老龄化研究人员工具箱一部分的方法（例如，验证口腔粘膜漏出液中 TNF-α 和 IL6 的测量，以及开发可在移动心理生理学货车中进行的现场友好的应激反应方案）。 公共卫生相关性：在美国，与种族/民族分类相关的健康差异仍然存在。消除这种健康差异对于公共卫生至关重要。了解与健康差异相关的因素对于消除这些差异至关重要。该应用程序包括侧重于更好地了解导致健康差异的生物、心理和社会因素的研究。