Race-based social stress and health trajectories from adolescence to adulthood

从青春期到成年基于种族的社会压力和健康轨迹

• 批准号: 7942989
• 负责人: JACQUELYNNE S ECCLES
• 金额: $ 40.42万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942989
• 关键词: Acute; Adolescence; Adolescent; Adolescent Development; Adult; African American; Age; Aging; Aging-Related Process; American; Anti-Inflammatory Agents; Anti-inflammatory; Arts; Autonomic nervous system; Behavior; Behavioral; Belief; Bioinformatics; Biological; Biological Markers; Biological Process; Cardiovascular system; Cells; Chronic Disease; Classification; Collection; Complement; Data; Data Collection; Development; Discrimination; Disease; Endocrine system; Ethnic Origin; European; Exposure to; Family; Feeling; Future; Gene Expression Profiling; Genes; Glucocorticoid Receptor; Glucocorticoids; Goals; Grant; Health; Home environment; IL6 gene; Immune; Individual; Inflammation; Inflammatory; Laboratories; Leukocytes; Longitudinal Studies; Maryland; Measurement; Measures; Mediating; Metabolic; Methods; Modeling; NF-kappa B; Neighborhoods; Occupational; Oral mucous membrane structure; Outcome; Parents; Participant; Pathway interactions; Pattern; Physiological; Plasma; Process; Production; Prospective Studies; Protocols documentation; Psyche structure; Psychophysiology; Public Health; Race; Recording of previous events; Recovery; Research Personnel; Resistance; Risk Factors; Sampling; Schools; Sleep; Socialization; Stress; System; Techniques; Transcriptional Regulation; Translating; Transudate; Tumor Necrosis Factor-alpha; Validation; Variant; Work; base; biological systems; cytokine; desensitization; diaries; ethnic discrimination; health disparity; healthy aging; human TNF protein; hypothalamic-pituitary-adrenal axis; peer influence; person centered; physical conditioning; psychologic; psychosocial; public health relevance; racial and ethnic; response; social; social stress; stressor; young adult

DESCRIPTION (provided by applicant): The broad aim of this Grand Opportunity Grant is to understand how race-based social stress, racial/ethnic (R/E) identity, and biological functioning contribute to health and healthy aging. Using the Maryland Adolescent Development in Context Study (MADICS) we propose to complement existing psychosocial, mental, and physical health data with the collection of a comprehensive set of measures of biological systems intimately tied to health and disease and highly relevant to the aging processes. MADICS is a nationally-recognized 17- year longitudinal study of family, school, neighborhood, and peer influences on the healthy and successful development of an initial sample of 1482 early adolescents and their families (60% African American, 35% European American, and similar proportions of "middle class" SES within these groups). Measures gathered across seven waves of data collection (ages 12 to 30) include histories of perceived discrimination based on race/ethnicity; beliefs, behaviors, and feelings about one's perceived R/E classification (i.e., R/E identity); mental and physical health; and psychosocial functioning (e.g., educational and occupational attainment). Here we propose to add a wide range of measures of biological systems associated with health and disease and highly relevant to the prospective study of aging processes. The primary goal is to explore how developmental histories of discrimination contribute to the pre-disease and health states of approximately 300 young adults (approximately 32 years old) and the extent to which these relations vary by R/E classification, SES, and R/E identity. Specifically, we will assess (1) the basal functioning of multiple physiological systems (endocrine, cardiovascular, metabolic, immune, inflammatory, sleep) reflecting well-established risk factors for a variety of poor health outcomes; (2) the acute reactivity and recovery of three physiological response systems tied to the development of chronic disease (i.e., hypothalamic-pituitary-adrenal [HPA] axis, autonomic nervous system, inflammatory system) in the context of a daily diary study and also in an experimental setting in which we expose individuals to a discriminatory episode; (3) inflammatory cytokine production and immune cell resistance to the anti-inflammatory effects of glucocorticoids, gene expression profiling of leukocytes to identify broad groups of genes associated with social stress (e.g., inflammation-related genes), and bioinformatic analyses to identify transcriptional control pathways that might potentially mediate these effects; and (4) person-centered health trajectory profiles constructed from mental and physical health and the proposed biomarkers and the extent to which their relations to histories of discrimination are moderated by R/E classification, SES, R/E identity, and parent socialization factors. An additional aim of this grant is to develop methods that can become part of the toolkit of future field-based health and aging researchers (e.g., validation of the measurement of TNF-alpha and IL6 in Oral Mucosal Transudate and the development of a field-friendly stress reactivity protocol that can be conducted in a mobile psychophysiological van). PUBLIC HEALTH RELEVANCE: Disparities in health associated with racial/ethnic classification persist in the US. The elimination of such health disparities is of paramount importance for public health. Understanding factors associated with health disparities is critical for their elimination. This application includes studies that focus on better understanding the biological, psychological, and social factors that contribute to health disparities.

描述（由申请人提供）：这项重大机会补助金的主要目的是了解基于种族的社会压力，种族/民族（R/E）身份和生物功能如何促进健康和健康老龄化。利用马里兰青少年发展背景研究（MADICS），我们建议通过收集与健康和疾病密切相关并与衰老过程高度相关的一套全面的生物系统测量来补充现有的社会心理、心理和身体健康数据。MADICS是一项全国公认的长达17年的纵向研究，旨在研究家庭、学校、社区和同伴对1482名早期青少年及其家庭健康和成功发展的影响（60%是非裔美国人，35%欧洲裔美国人，以及这些群体中类似比例的“中产阶级”SES）。通过七波数据收集（12岁至30岁）收集的措施包括基于种族/族裔的感知歧视历史；对自己感知的R/E分类（即R/E身份）的信念、行为和感受；身心健康；以及社会心理功能（如教育和职业成就）。在这里，我们建议增加与健康和疾病相关的生物系统的广泛测量，并与衰老过程的前瞻性研究高度相关。本研究的主要目标是探讨歧视发展史如何影响约300名年轻人（约32岁）的病前和健康状态，以及这些关系在多大程度上因性别/性别分类、社会地位和性别/性别身份而变化。具体来说，我们将评估(1)多个生理系统（内分泌、心血管、代谢、免疫、炎症、睡眠）的基础功能，反映出各种不良健康结果的已知风险因素；(2)在日常日记研究的背景下，以及在我们将个体暴露于歧视性事件的实验环境中，与慢性疾病发展相关的三个生理反应系统（即下丘脑-垂体-肾上腺[HPA]轴，自主神经系统，炎症系统）的急性反应性和恢复；(3)炎性细胞因子的产生和免疫细胞对糖皮质激素抗炎作用的抵抗，白细胞的基因表达谱，以确定与社会压力相关的广泛基因群（例如，炎症相关基因），以及生物信息学分析，以确定可能介导这些作用的转录控制途径；(4)由身心健康和生物标志物构建的以人为中心的健康轨迹曲线，以及它们与歧视史的关系在多大程度上受到R/E分类、社会地位、R/E身份和父母社会化因素的调节。这笔拨款的另一个目的是开发方法，使其成为未来现场健康和老龄化研究人员工具包的一部分（例如，验证口腔粘膜渗出液中tnf - α和il - 6的测量，以及开发可在移动心理生理面包车中进行的现场友好的应激反应方案）。