Community Development of the Cell Centered Database

描述(申请人提供)：细胞中心数据库(CCDB)于2002年发布，是一个网络可访问的数据库，用于从光学和电子显微镜成像(包括相关光学和电子显微镜)获得高分辨率2D、3D和4D数据。CCDB包含并托管了介于大体形态和大分子结构之间的维度范围内的许多类型的数据--即所谓的“中尺度”。这些数据以及托管和服务这些数据的软件基础设施在范围上是独一无二的，向社区提供的数据集充满了技术上难以获得但内容非常丰富的信息，使它们对于开发细胞和组织中发生的结构和生理过程的计算模型特别有价值。从1998年该项目开始，CCDB就被设想为一个网格和/或基于网络的联合数据库系统，它率先生产了一个分布式、可连接的储存库系统，用于管理和共享数据，供越来越多的显微镜研究人员使用。这项提议旨在通过完善核心服务和建立所需设施，为以细胞为中心的数据库不断扩大的用户群体提供稳定的支持基础，并为不断扩大的参与者群体公开共享、修改、扩展、编辑和记录CCDB数据和软件提供所需设施。拟议的工作安排为三个具体目标：目标1.开放源码CCDB：目前的系统基础设施将从一个具有明确社区需求的中央支持的研究产品转变为一个为整个社区的贡献、定制和改进量身定做的行业模式的开放源码项目。目标2：CDB核心服务：将CCDB的主要组件(模式、核心服务)打包，通过开源分发模式进行社区分发和提炼。将提供Documentaiton以及对CCDB核心服务的存储库/集合进行扩展的“社区贡献”的规范。目标3：CCDB客户端工具：将打包并分发现有的CCDB客户端工具，供最终用户社区使用。

DESCRIPTION (provided by applicant): The Cell Centered Database (CCDB) was released in 2002 as a web-accessible database for high resolution 2D, 3D and 4D data derived from light and electron microscopic imaging, including correlated light and electron microscopy. The CCDB encompasses and hosts many types of data in the dimensional range lying between gross morphology and macromolecular structure - the so-called "mesoscale". These data and the software infrastructure that hosts and serves them are unique in scope, presenting to the community data sets laden with information which is technically difficult to obtain but very rich in content, making them particularly valuable for developing computational models of structures and physiological processes that occur in cells and tissues. Envisioned as a grid and/or web-based federated database system from the beginning of the project in 1998, the CCDB pioneered the production of a distributed, connectable repository system for managing and sharing data for a growing research community of microscopists. This proposal aims to provide a stable base of support for a growing community of users of the Cell Centered Database, by refining core services and establishing the facilities needed for CCDB data and software to be openly shared, modified, extended, edited and documented by the expanding participant group. The proposed work is organized into three specific aims: Aim 1. Open Source CCDB: The current system infrastructure will be translated from a centrally supported research product with defined community requirements to an industrymodeled open source project tailored for community wide contribution, customization and refinement. Aim 2: CDB Core Services: The principal components (schema, core services) of the CCDB will be packaged for community distribution and refinement via open source distribution model. Documentaiton will be provided along with specifications for expanded "community contribution" to a repository/collection of core CCDB services. Aim 3: CCDB Client Tools: Existing CCDB client tools will be packaged and distributed for use by the end-user community.