Institute for Biogenesis Research: COBRE

生物起源研究所：COBRE

• 批准号: 7754302
• 负责人: WILLIAM S WARD
• 金额: $ 18.4万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-29 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7754302
• 关键词: Academy; Anatomy; Area; Award; Basic Science; Biogenesis; Burn injury; Centers of Research Excellence; Child; Clinical; Cloning; Congenital Abnormality; Core Facility; Data; Development; Discipline of obstetrics; Embryonic Development; Event; Faculty; Fertilization; Fertilization in Vitro; Foundations; Gynecology; Hawaii; Health; In Vitro; Infertility; Institutes; Interdisciplinary Study; Intracytoplasmic Sperm Injections; Link; Mammals; Mediating; Mentors; Molecular; Phase; Recruitment Activity; Reproduction; Reproductive Biology; Reproductive Health; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Resources; Science; Senior Scientist; Staging; Structure; Techniques; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Translational Research; United States National Institutes of Health; Universities; base; career; career development; clinically relevant; design; forging; improved; innovation; interdisciplinary collaboration; medical schools; member; programs; research study; response; translational study

DESCRIPTION (provided by applicant): The John A. Burns School of Medicine (JABSOM) at the University of Hawaii at Manoa (UH Manoa) is submitting this application in response to National Institutes of Health (NIH) PAR-07-229. With a Center of Biomedical Research Excellence (COBRE) award, we seek to transform JABSOM's Institute for Biogenesis Research (IBR) into an interdisciplinary, translational research institute for reproductive biology. The IBR was established in 1999 by the State of Hawaii and UH Manoa in JABSOM's Department of Anatomy & Reproductive Biology. Its rationale was to continue the legacy of reproductive biology research pioneered by National Academy member Dr. Ryuzo Yanagimachi. Dr. Yanagimachi and his team produced major breakthroughs in reproductive biology, including the development of intracytoplasmic sperm injection (ICSI), the principles underlying in vitro fertilization (IVF) in mammals, the first demonstration of repetitive mammalian cloning, and ICSI-mediated transgenic mice. We propose expansion of the IBR through collaboration, interdisciplinary mentoring, and creation of a transgenic Core. Such expansion will build upon the IBR's foundation of outstanding basic science while directing its research emphasis toward interdisciplinary, translational research in reproductive biology. The IBR's research focus lies in early molecular events in mammalian embryogenesis and their effects on later stages of development. Through partnership with the clinical Department of Obstetrics and Gynecology and Pacific IVF Institute, we will support translational projects designed to advance the science of reproduction and reduce infertility and birth defects for children through the latest molecular, cellular, and micro-techniques, many of which were developed at UH. We seek to accomplish this objective through the following specific aims. In Specific Aim 1, we will transform the Institute for Biogenesis Research (IBR) into a nationally competitive, interdisciplinary, translational reproductive biology research center. The focus of Specific Aim 2 will be to advance the science of reproduction and infertility and improve institutional capacity by engaging senior scientists to mentor junior investigators through interdisciplinary research studies and career development activities. In Specific Aim 3 we will improve institutional capacity by drawing upon the center's expertise to develop a transgenic animal Core that will benefit investigators throughout the university. The IBR COBRE will contribute to infrastructure at UH Manoa by enhancing Core resources available for investigators across campus, and will support talented junior faculty toward independence as they conduct innovative basic, clinical and translational studies designed to produce data relevant to reproductive health.

描述（由申请人提供）：夏威夷大学马诺阿分校 (UH Manoa) 的 John A. Burns 医学院 (JABSOM) 提交此申请是为了回应美国国立卫生研究院 (NIH) PAR-07-229。凭借生物医学研究卓越中心 (COBRE) 奖项，我们力求将 JABSOM 生物发生研究所 (IBR) 转变为生殖生物学的跨学科、转化型研究所。 IBR 于 1999 年由夏威夷州和夏威夷大学马诺阿分校在 JABSOM 解剖学和生殖生物学系建立。其基本原理是延续国家科学院院士柳町龙三博士开创的生殖生物学研究遗产。 Yanagimachi 博士和他的团队在生殖生物学领域取得了重大突破，包括胞浆内单精子注射 (ICSI) 的发展、哺乳动物体外受精 (IVF) 的原理、首次演示哺乳动物重复克隆以及 ICSI 介导的转基因小鼠。我们建议通过合作、跨学科指导和创建转基因核心来扩展 IBR。这种扩展将建立在 IBR 杰出基础科学的基础上，同时将其研究重点转向生殖生物学的跨学科、转化研究。 IBR 的研究重点在于哺乳动物胚胎发生的早期分子事件及其对发育后期的影响。通过与妇产科临床系和太平洋试管受精研究所合作，我们将支持旨在通过最新的分子、细胞和微技术（其中许多技术是在夏威夷大学开发的）推进生殖科学并减少儿童不孕症和出生缺陷的转化项目。我们力求通过以下具体目标来实现这一目标。在具体目标 1 中，我们将把生物发生研究所 (IBR) 转变为具有全国竞争力的跨学科转化生殖生物学研究中心。具体目标 2 的重点是通过跨学科研究和职业发展活动聘请资深科学家指导初级研究人员，从而推进生殖和不孕不育科学的发展并提高机构能力。在具体目标 3 中，我们将利用该中心的专业知识来开发转基因动物核心，从而提高机构能力，这将使整个大学的研究人员受益。 IBR COBRE 将通过增强整个校园研究人员可用的核心资源，为夏威夷大学马诺阿分校的基础设施做出贡献，并将支持有才华的初级教师走向独立，因为他们进行创新的基础、临床和转化研究，旨在产生与生殖健康相关的数据。