A Laser Microbeam Biotechnology Resource

激光微束生物技术资源

• 批准号: 7849181
• 负责人: Bruce J. Tromberg
• 金额: $ 16.35万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-04 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849181
• 关键词: Laser; Microbeam; Biotechnology; Resource

DESCRIPTION (provided by applicant): The Laser Microbeam and Medical Program (LAMMP) is a NIH Biomedical Technology Resource Center dedicated to the use of lasers and optics in biology and medicine. LAMMP is located within the Beckman Laser Institute (BLI), an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. Overall resource objectives are to promote a well-balanced Center with activities in technological research and development, collaborative research, service, training, and dissemination. In this sixth renewal application of LAMMP, we continue to emphasize our unique capabilities to facilitate "translational" research by rapidly moving basic science and technology discoveries from "blackboard to benchtop to bedside". This is accomplished by combining state of the art optical technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinical care. LAMMP provides both Microscopy and Microbeam Technologies (MMT) for high-resolution functional imaging and manipulation of living cells and tissues and Medical Translational Technologies (MTT) for non- and minimally-invasive monitoring, treating, and imaging pre-clinical animal models and human subjects. In addition, we propose to establish a new core, Virtual Photonics Technologies (VPT) for developing computational models and methods that advance the performance of biophotonic technologies, and enhance the information content derived from optical measurements. Seven Technology Research and Development projects are proposed that will result in the fabrication of several new instruments as well as the creation of multi-functional software. These projects build on our longstanding expertise in light-tissue interaction models and Biophotonics technologies, including laser microbeams, non-linear microscopy, optical coherence tomography, spatial/temporal modulation methods, and diffuse optics. LAMMP cores contain complementary technologies that are capable of quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Collaborative studies are proposed that advance these technologies so they become widely-available, enabling methods in Biology and Medicine. Throughout the grant we emphasize the relevance of LAMMP technologies to Medicine in areas such as cancer, cardiovascular disease, metabolic syndrome, and neurologic function, as well as fundamental biological process, such as mechano-transduction, wound repair, angiogenesis, fibrosis, and cell death.

描述（由申请人提供）：激光微束和医学计划 (LAMMP) 是 NIH 生物医学技术资源中心，致力于激光和光学在生物学和医学中的应用。 LAMMP 位于贝克曼激光研究所 (BLI) 内，该研究所是加州大学欧文分校的一个跨学科生物医学研究、教学和临床机构。总体资源目标是促进中心在技术研究和开发、协作研究、服务、培训和传播方面的活动均衡发展。在 LAMMP 的第六次更新应用中，我们继续强调我们通过快速将基础科学和技术发现从“黑板到台式到床边”促进“转化”研究的独特能力。这是通过将最先进的光学技术与细胞和组织工程、组织病理学、临​​床前动物模型和临床护理的专门资源设施相结合来实现的。 LAMMP 提供用于活细胞和组织的高分辨率功能成像和操作的显微镜和微束技术 (MMT)，以及用于无创和微创监测、治疗和成像临床前动物模型和人类受试者的医学转化技术 (MTT)。此外，我们建议建立一个新的核心——虚拟光子技术（VPT），用于开发计算模型和方法，以提高生物光子技术的性能，并增强从光学测量中获得的信息内容。提出了七个技术研究和开发项目，这些项目将导致制造几种新仪器以及创建多功能软件。这些项目建立在我们在光组织相互作用模型和生物光子学技术方面的长期专业知识的基础上，包括激光微束、非线性显微镜、光学相干断层扫描、空间/时间调制方法和漫射光学。 LAMMP 核心包含补充技术，能够定量表征、成像以及扰动细胞和组织中的结构和生化功能，具有从微米到厘米的可扩展分辨率和深度灵敏度。建议开展合作研究来推进这些技术，使它们变得广泛可用，从而成为生物学和医学领域的方法。在整个资助过程中，我们强调 LAMMP 技术与癌症、心血管疾病、代谢综合征和神经功能等领域的医学相关性，以及机械传导、伤口修复、血管生成、纤维化和细胞死亡等基本生物过程的相关性。