Stress, Lead, Iron Deficiency and Neurodevelopment

压力、铅、缺铁和神经发育

• 批准号: 7741222
• 负责人: Robert O Wright
• 金额: $ 51.72万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7741222
• 关键词: 3 year old; Address; Age-Months; American; Anemia; Animals; Archives; Area Under Curve; Biological; Biological Markers; Birth; Blood; British; Chemicals; Child; Child Development; Chronic; Chronic stress; Cities; Cognitive; Cohort Analysis; Cohort Studies; Communities; Complex; Data; Data Analyses; Development; Dietary Iron; Dose; Effectiveness; Environmental Health; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Feasibility Studies; Funding; Future; Genes; Genotype; Goals; Hemoglobin; Human; Hydrocortisone; Infant; Infant Development; Institutes; Intake; International; Intervention; Investigation; Iron; Iron deficiency anemia; Joints; Laboratories; Lead; Lead Poisoning; Life; Light; Link; Malnutrition; Measures; Mediating; Medical center; Mexico; Modification; Mothers; Nature; Neurotoxins; Outcome; Participant; Pediatrics; Pilot Projects; Poisoning; Predisposition; Pregnancy; Pregnant Women; Prevention; Prevention strategy; Psychological Stress; Psychosocial Stress; Public Health; Public Health Schools; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resistance; Salivary; Sample Size; Sampling; Secondary Prevention; Series; Social Environment; Social Sciences; Stress; Testing; Toxic effect; Toxicology; Treatment Protocols; United States National Institutes of Health; Validation; Work; cohort; design; developmental psychology; early childhood; gene environment interaction; health disparity; improved; indexing; interest; lead exposure; maternal stress; molecular marker; neurodevelopment; neurotoxicity; nutrition; prenatal; prospective; response; skills; social; social stress; socioeconomics; stressor; therapy design

Social stressors, iron deficiency anemia, and lead exposure are all environmental risk factors for poor neurodevelopment in young children. All three factors are highly prevalent in poor communities, whether in Mexico or the U.S. There are scant human epidemiologic studies on chronic social stress and human neurodevelopment. In addition, previous studies of child development and neurotoxicants have typically analyzed covariate markers of social stress as independent predictors of neurodevelopment; and thus, only considered social factors as potential confounders in their data analysis. There are biological reasons to believe that stress potentiates the toxicity of iron deficiency anemia and lead poisoning. If so, then understanding this relationship may be the key to designing effective public health interventions designed to improve neurodevelopment and may explain the lack of effectiveness of prevention/treatment regimens for lead poisoning and iron deficiency. A prospective cohort study with a large sample size is needed to address the potential multiplicative effects of combined stress/iron deficiency anemia and combined stress/lead exposure in predicting infant development. This resubmission includes new data from a pilot study of stress-lead/stress-anemia interactions in 120 mother infant pairs conducted since the prior application, which demonstrates study feasibility and evidence for the hypothesized interactions. In this proposal we will measure maternal stress levels, infant iron deficiency anemia and lead exposure in a cohort of mother-infant pairs living in Mexico City and longitudinally measure maternal stress, iron stores, lead exposure, salivary cortisol and neurodevelopment beginning pre-natally and extending 3 years post-partum. This project will determine the independent effect of pre- and post-partum maternal stress in predicting infant development, and the multiplicative joint effects of maternal stress/iron deficiency and maternal stress/lead poisoning in predicting infant development.

社会压力、缺铁性贫血和铅暴露都是穷人的环境风险因素