TWO-LASER FPOP AND PROTEIN FOLDING
TWO-LASER FPOP AND PROTEIN FOLDING
批准号:
8168814
负责人:
MICHAEL L GROSS
金额:
$1.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-03-10 至 2010-12-31
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
利用FPOP作为一种快速标记策略的优势,我们正在建立一个双激光系统,该系统利用Nd:YAG激光和拉曼移位器来快速加热蛋白质,然后使用第二个激光在展开过程中产生自由基来足迹蛋白质。这种方法将使我们能够在微秒的时间尺度上探测蛋白质的动力学。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Taking advantage of FPOP as a fast labeling strategy, we are building a two laser system that utilizes a Nd:YAG laser and a Raman shifter to quickly heat a protein, and then use the second laser to generate radicals to footprint the protein during unfolding. This method will allow us to probe protein dynamics on a microsecond time scale.
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会议论文
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical Projects
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批准号:10441142
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项目类别:
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资助金额:$65.99万
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财政年份:2020
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负责人:MICHAEL L GROSS
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依托单位:
New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells
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批准号:10350642
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项目类别:
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资助金额:$40.98万
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财政年份:2019
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负责人:MICHAEL L GROSS
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依托单位:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID
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批准号:10390166
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项目类别:
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资助金额:$25.0万
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财政年份:2019
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负责人:MICHAEL L GROSS
-
依托单位:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS
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批准号:10587527
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项目类别:
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资助金额:$46.57万
-
财政年份:2019
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负责人:MICHAEL L GROSS
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依托单位:
A MASS SPECTROMETER FOR PROTEIN FOOTPRINTING
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批准号:8637341
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项目类别:
-
资助金额:$44.99万
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财政年份:2014
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负责人:MICHAEL L GROSS
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依托单位:
APPROACHES TO IMPROVE PROTEIN FOOTPRINTING: HIGH PRESSURE DIGESTION
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批准号:8361405
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项目类别:
-
资助金额:$1.57万
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财政年份:2011
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负责人:MICHAEL L GROSS
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依托单位:
HIGH ENERGY COLLISIONAL ACTIVATION
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批准号:8361422
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项目类别:
-
资助金额:$0.63万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
UNDERGRADUATE TRAINING IN MASS SPECTROMETRY
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批准号:8361432
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项目类别:
-
资助金额:$0.2万
-
财政年份:2011
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负责人:MICHAEL L GROSS
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依托单位:
VISITING SCIENTISTS
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批准号:8361338
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项目类别:
-
资助金额:$0.52万
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财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
STRUCTURAL STUDIES OF GRAMICIDIN & OTHER SELF-ASSOCIATING PEPTIDES
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批准号:8361321
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项目类别:
-
资助金额:$0.31万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
CONTRIBUTED PRESENTATIONS AT CONFERENCES
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批准号:8361333
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项目类别:
-
资助金额:$2.11万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
INVITED LECTURES AT UNIVERSITIES & CONFERENCES
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批准号:8361336
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项目类别:
-
资助金额:$0.74万
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财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
TOXICOLOGICAL EFFECTS OF QUINONES
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批准号:8361377
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项目类别:
-
资助金额:$1.26万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
DEVELOPMENT AND APPLICATION OF PLIMSTEX
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批准号:8361324
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项目类别:
-
资助金额:$3.8万
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财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
CONSULTING FOR NCRR AND NIBIB RESOURCES
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批准号:8361475
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项目类别:
-
资助金额:$0.43万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
DEVELOPMENT OF PROTEIN TOOL BOX SOFTWARE MODULES
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批准号:8361369
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项目类别:
-
资助金额:$0.63万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
SCIENTIFIC JOURNAL EDITING
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批准号:8361334
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项目类别:
-
资助金额:$0.2万
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财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
COMPUTATIONAL METHODS FOR FRAGMENTATION OF BIOMOLECULES - LIPIDS
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批准号:8361318
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项目类别:
-
资助金额:$0.79万
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财政年份:2011
-
负责人:MICHAEL L GROSS
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依托单位:
ENCYCLOPEDIA OF MASS SPECTROMETRY
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批准号:8361339
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项目类别:
-
资助金额:$0.2万
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财政年份:2011
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负责人:MICHAEL L GROSS
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依托单位:
SEPARATION METHODS FOR COMPLEX MIXTURES
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批准号:8361351
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项目类别:
-
资助金额:$0.94万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
海外基金