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TWO-LASER FPOP AND PROTEIN FOLDING

TWO-LASER FPOP AND PROTEIN FOLDING
两激光 FPOP 和蛋白质折叠
批准号：
8168814
负责人：
MICHAEL L GROSS
金额：
$1.16万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-03-10 至 2010-12-31
来源：
https://reporter.nih.gov/project-details/8168814
关键词：
Computer Retrieval of Information on Scientific Projects DatabaseFundingGrantHeatingInstitutionLabelLasersMethodsProtein DynamicsProtein FootprintingProteinsResearchResearch PersonnelResourcesSourceSystemTimeUnited States National Institutes of Healthprotein folding

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Taking advantage of FPOP as a fast labeling strategy, we are building a two laser system that utilizes a Nd:YAG laser and a Raman shifter to quickly heat a protein, and then use the second laser to generate radicals to footprint the protein during unfolding. This method will allow us to probe protein dynamics on a microsecond time scale.
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