NCMRR-DC Core Molecular & Functional Outcome Measures in Rehabilitation Medicine

描述（由申请人提供）：医学康复是一个跨年龄的研究和临床问题。早产儿需要多种类型的康复（身体、呼吸、职业），脑瘫和脊柱裂患儿有广泛的康复需求。患有脊髓、脑和肢体创伤的成年人都需要广泛的康复支持。研究改善功能结果，了解特定残疾的病理生理学，对于患者的生活质量和卫生保健系统的负担都是重要的。我们的NCMRR-DC核心的目标是在康复研究的分子和功能结果测量方面提供技术服务和培训。在上一个授奖期间，我们的NCMRR核心为32个机构的108名主要研究人员提供了服务和培训，处理和分析了4,500个样本。教学和外联工作包括对外部调查人员进行350 000小时的现场培训，95次特邀演讲，29次在国家和国际会议上发言，以及组织讲习班编写和传播功能结果衡量标准作业程序。在这种竞争性更新应用中，pi已经扩展了他们的分子结果服务和培训，包括小鼠和人类的功能结果。这些措施包括临床评估人员服务和培训，小鼠功能测试设施，以及促进在已有的人类队列中进行辅助研究，强调功能结果。这些新资源是在过去4年中建立起来的，已被国际康复研究界大量利用，现在被提议作为NCMRR-DC核心的一部分。

DESCRIPTION (provided by applicant): Medical rehabilitation is a research and clinical concern across the age span. Premature infants require rehabilitation of multiple types (physical, respiratory, occupational), children with cerebral palsy and spina bifida have extensive rehabilitation needs. Adults with spinal cord, brain, and limb trauma all require extensive rehabilitation support. Research to improve functional outcomes, and understand the pathophysiology of specific disabilities is important, both for patient quality of life, as well as burden on the health care system. The goal of our NCMRR-DC Core is to provide technical services and training across both molecular and functional outcome measures in rehabilitation research. During the previous award period, our NCMRR Core provided services and training to 108 principal investigators in 32 institutions, with processing and analysis of >4,500 samples. Didactic and outreach efforts included >3,500 hrs of on-site training of external investigators, 95 invited lectures, 29 presentations at national and international conferences, and organization of workshops to write and disseminate standard operating procedures for functional outcome measures. In this competitive renewal application, the PIs have extended their molecular outcomes services and training to include murine and human functional outcomes. These include clinical evaluator services and training, a murine functional testing facility, and facilitation of ancillary studies in pre-existing human cohorts emphasizing functional outcomes. These new resources have been established over the last 4 years, have been heavily utilized by the international rehabilitation research community, and are now proposed as a part of the NCMRR-DC Core. PUBLIC HEALTH RELEVANCE: Research to improve functional outcomes, and understand the pathophysiology of specific disabilities is important, both for patient quality of life, as well as burden on the health care system. The goal of the NCMRR-DC Core is to provide technical services and training across both molecular and functional outcome measures in rehabilitation research.