New Targets for Reproductive Control of Mosquito Vectors

蚊媒生殖控制的新目标

• 批准号: 8160310
• 负责人: Laura C Harrington
• 金额: $ 40.63万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8160310
• 关键词: Aedes; Asians; Blood; Chikungunya virus; Culicidae; Dengue; Dengue Virus; Disease; Disease Vectors; Female; Goals; Incidence; Insecta; Mosquito Control; Partner in relationship; Physiology; Proteins; Seminal fluid; Tigers; Time; Virus; Yellow Fever; base; chikungunya; feeding; male; novel; pathogen; reproductive; transmission process; vector control; vector mosquito

DESCRIPTION (provided by applicant): New Targets for Reproductive Control of Mosquito Vectors. In this project, we will investigate the male seminal fluid proteins (SFPs) of two major disease vectors of dengue and Chikungunya viruses: the yellow fever mosquito (Aedes aegypti) and the Asian tiger mosquito (Aedes albopictus). Both dengue and Chikungunya are increasing in incidence globally and there is an immediate need to develop novel and effective vector control strategies for these two species. In this study we will conduct two specific aims to identify and functionally characterize SFPs, for the first time, in Ae. aegypti and Ae. albopictus. Our goal is to directly identify new mosquito SFP targets that could be manipulated as a novel means of reproductive control, or to modify the blood feeding physiology of insects that transmit deadly pathogens, with the long-term goal to reduce or eliminate virus transmission to people. PUBLIC HEALTH RELEVANCE: In this study, we will directly identify and determine the function of seminal fluid proteins produced in male mosquitoes and transferred to females during mating. We will identify targets that could be manipulated as a novel means of reproductive control or as a means of modifying the blood feeding physiology of insects that transmit deadly pathogens causing diseases such as dengue and Chikungunya, with the long-term goal to reduce or eliminate virus transmission to people.

描述（由申请人提供）：蚊媒繁殖控制的新目标。本项目将对登革热病毒和基孔肯雅病毒两种主要病媒：黄热病蚊（埃及伊蚊）和亚洲虎蚊（白纹伊蚊）的雄性精液蛋白（SFPs）进行研究。登革热和基孔肯雅热在全球的发病率都在上升，目前迫切需要为这两个物种制定新的有效的病媒控制战略。在这项研究中，我们将进行两个具体的目标，首次在Ae中鉴定和功能表征SFPs。埃及伊蚊和伊蚊。蚊。我们的目标是直接确定新的蚊子SFP靶点，这些靶点可以作为一种新的生殖控制手段，或者改变传播致命病原体的昆虫的血液摄食生理，长期目标是减少或消除病毒向人类的传播。