Weight-Bearing Imaging of the Knee Using C-Arm CT
使用 C 臂 CT 进行膝盖负重成像
基本信息
- 批准号:8902732
- 负责人:
- 金额:$ 50.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-01 至 2019-02-28
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAccountingActivities of Daily LivingAdultAffectAgingAlgorithmsArthralgiaArthritisArthrographyBehaviorBiochemical MarkersBiomechanicsBone TissueCadaverCardiologyCartilageCollaborationsDataDegenerative polyarthritisDevelopmentDevicesDiagnosisDiagnostic radiologic examinationDoseElementsEnsureEnvironmentEvaluationGeometryGoalsHealthHealth Care CostsHumanImageImage AnalysisImaging TechniquesInpatientsInterventionJointsKneeKnee OsteoarthritisKnee jointLengthLettersLimb structureLower ExtremityMagnetic Resonance ImagingMeasurementMeasuresMechanical StimulationMechanical StressMechanicsMeniscus structure of jointMetabolicModelingMorphologic artifactsMorphologyMotionMuscleMyocardiumOperative Surgical ProceduresPainPathway interactionsPatientsPatternPhysicsPhysiologicalPilot ProjectsPlayPopulationPositioning AttributePropertyProtocols documentationRadiology SpecialtyReportingResearchResolutionRiskRoleScanningStagingStressStress TestsSymptomsSystemTechnologyTendon structureTestingThickTimeTissuesUnited StatesUniversitiesWeight-Bearing stateWorkX-Ray Computed Tomographyarmarticular cartilagebasebonecostdata acquisitiondesignexperiencefunctional declinefunctional disabilityhigh riskimaging biomarkerimaging platformimaging systemin vivoinsightjoint stresskinematicsknee replacement arthroplastynew technologynovelnovel strategiespublic health relevancequantitative imagingreceptorreconstructionresponseskeletal tissuesoft tissuetooltreatment strategy
项目摘要
DESCRIPTION (provided by applicant): The joint most often implicated in lower extremity osteoarthritis (OA) is the knee, where major symptoms include pain and stiffness. Skeletal tissues are regulated by their mechanical environment and receptors within bone and soft tissue that respond to mechanical stimulation are believed to play a major role in joint pain. One potential pathway for the onset and progression of OA is due to abnormal joint kinematics, resulting in elevated joint stress and cartilage damage. Treatments that alter mechanical stresses and metabolic activity in bone may be an effective strategy to alleviate pain in these patients. However, clinicians are unable to diagnose or treat these `pathomechanics' as they lack the tools to assess weight-bearing knee function and tissue stress. The overarching goal of this research is to develop novel weight-bearing computed tomography (CT) imaging to support a quantitative measure of knee joint health that measures both morphology and mechanics of the joint. As a first step towards this goal, we will research and optimize a new, very high resolution (210 µm isotropic), C-arm CT-based imaging test that will measure cartilage deformation as a function of time with the subject standing in a fully weight-bearing position. We hypothesize that a mechanical model of the deformation-load curve will provide a sensitive and early imaging biomarker of OA status due to differences in cartilage material properties and their response to mechanical loading. We will optimize the acquisition of the deformation-time curve in ex vivo cadaver knees, and conduct a 40-subject preliminary study to demonstrate the potential sensitivity of the new imaging biomarker to distinguish between non-OA and different stages of OA progression. We believe that our new joint health test will enable testing of patient-specific treatment strategies that may slow or reverse the progression of knee OA.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Garry E Gold', 18)}}的其他基金
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
- 批准号:
10425333 - 财政年份:2019
- 资助金额:
$ 50.3万 - 项目类别:
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
- 批准号:
10202485 - 财政年份:2019
- 资助金额:
$ 50.3万 - 项目类别:
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
- 批准号:
10659207 - 财政年份:2019
- 资助金额:
$ 50.3万 - 项目类别:
Weight-Bearing Imaging of the Knee Using C-Arm CT
使用 C 臂 CT 进行膝盖负重成像
- 批准号:
9042244 - 财政年份:2015
- 资助金额:
$ 50.3万 - 项目类别:
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