Advanced MR Imaging of Early Osteoarthritis

描述(由申请人提供)：这是一份新的以患者为中心的职业生涯中期研究人员奖的申请(K24)。申请者Garry Gold博士是一名内科科学家，斯坦福大学放射学、生物工程和整形外科副教授。在过去的10年里，戈尔德博士在几种先进的肌肉骨骼成像和生物力学技术方面积累了专业知识，并将这些技术应用于骨关节炎和关节疾病的研究。这导致他发展了独立的以患者为导向的研究(POR)职业生涯。他获得了美国国立卫生研究院的两项独立研究奖，这两项研究利用磁共振技术研究肌肉骨骼疾病的病理生理学(两者都来自NIBIB)。戈尔德博士有10年指导初级临床医生科学家、博士后研究员、医学生、研究生和本科生的历史--所有人都在进行POR。此外，戈尔德博士还与NIH资助的许多研究人员在肌肉骨骼研究和成像领域进行了积极的合作。目前的申请要求提供为期5年的资金(40%工资)。这笔资金将保证候选人将有至少50%的保护时间来进行他正在进行的研究，并继续指导进行POR的临床医生科学家。这一奖项将腾出现在专门用于行政和临床责任的时间，以便在未来5年更多地专注于他的研究和指导活动。除了参与美国国立卫生研究院正在进行的两个项目外，戈尔德博士还将接受高级磁共振采集和分析方法方面的额外培训。这将使候选人能够开发新的方法来应用于肌肉骨骼疾病的成像。鉴于斯坦福大学出色的资源和合作，这些新颖的项目有望得到更新或引领整形外科研究的新方向，并对我们的科学理解做出重大贡献 这些致残条件。

DESCRIPTION (provided by applicant): This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions.