Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis

项目摘要 骨性关节炎是世界范围内导致残疾的主要原因。非侵入性技术无法 量化疾病进展对骨性关节炎的发病机制了解有限。虽然无数的磁力 磁共振成像(MRI)方法已被提出用于骨关节炎的成像，对骨代谢的敏感性 是有限的。我们建议开发用于骨和软组织的先进的三维PET-MRI方法 代谢研究关节组织对膝关节负荷变化的反应。这项工作将带来一个新的 通过揭示软骨和骨骼变化之间的关系来认识骨性关节炎的发病机制 随着时间的推移新陈代谢。 本项目旨在开发PET-MRI方法，以灵敏地跟踪骨关节炎对生物力学的响应 正在装车。我们的具体目标是(1)开发准确的、可重复性的和剂量优化的动力学模型 基于深度学习和高级MR的动态18F-NaF PET-MRI双侧全关节定量成像 线圈技术，(2)利用正电子发射计算机断层扫描技术研究静息状态骨代谢与生物力学的关系。 核磁共振和(3)进行纵向研究，以评估我们的新成像方法对关节变化的反应 步态再训练的生物力学。 这项工作的创新在于开发了新的成像技术，同时提供了 用PET-MRI定量测量软骨和骨的组织生理学。这项工作的意义 我们将能够灵敏地和定量地跟踪骨骼代谢和软组织的变化 随着时间的推移，膝关节中生物力学载荷的变化导致微观结构的变化。这将提供新的和 评估关节对生物力学干预治疗此类骨性关节炎的反应的更灵敏的成像工具 如步态再训练、支撑或胫骨高位截骨术。

Project Summary Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, sensitivity to bone metabolism has been limited. We propose to develop advanced three-dimensional PET-MRI methods for bone and soft tissue metabolism to study the response of the tissues in the joint to changes in knee load. This work will lead to a new understanding of OA pathogenesis by revealing relationships between changes in cartilage and bone metabolism over time. This project aims to develop PET-MRI methods to sensitively track changes of OA in response to biomechanical loading. Our specific aims are to (1) Develop accurate, reproducible and dose-optimized kinetic models of dynamic 18F-NaF PET-MRI for quantitative bilateral whole joint imaging using deep learning and advanced MR coil technology, (2) Study the relationship between resting state bone metabolism and biomechanics using PET- MRI and (3) Perform a longitudinal study to assess the response of our new imaging methods to changes in joint biomechanics from gait retraining. The innovation of this work lies in the development of novel imaging techniques that simultaneously offer quantitative measures of tissue physiology in cartilage and bone using PET-MRI. The significance of this work is that we will be able to sensitively and quantitatively track changes in bone metabolism and soft tissue microstructure due to changes in biomechanical loading in the knee joint over time. This will provide new and more sensitive imaging tools to assess the responses of the joint to biomechanical interventions to treat OA such as gait retraining, bracing, or high tibial osteotomy.