Osteoarthritis: Quantitative Evaluation of Whole Joint Disease with MRI

项目摘要 骨关节炎（OA）是一个巨大的临床问题和世界范围内的残疾原因。 OA新疗法的开发受到缺乏敏感的成像测试的阻碍， 应对疾病状态的变化。最近FDA和CE批准的临床膝关节7T MRI 增加OA进展的高级MRI生物标志物的敏感性和特异性的潜力。 本项目将比较两个不同供应商系统中3T和7T的变化， 评估7T MRI的潜力，以提高我们研究和开发新疾病的能力， 改良疗法这项研究将加强未来的研究和临床检查在7T，可以 用于通过机器学习重建和增强来改善常规3T MRI 了解OA的发病机制。了解3T和7T的相对优势 MRI在这一重要的临床应用中对于开发新的疾病修饰 治疗OA患者。

Project Summary Osteoarthritis (OA) is an enormous clinical problem and worldwide cause of disability. Development of new therapies for OA is hampered by a lack of sensitive imaging tests that respond to changes in disease status. Recently FDA and CE approved clinical knee 7T MRI has the potential to add sensitivity and specificity to advanced MRI biomarkers of OA progression. This project will compare changes seen at 3T and 7T across two different vendors systems and assess the potential for 7T MRI to improve our ability to study and develop new disease- modifying therapies. This study will enhance future studies and clinical exams at 7T and can be used to improve routine 3T MRI though machine learning reconstruction and enhanced understanding of OA disease mechanisms. Understanding the relative strengths of 3T and 7T MRI in this important clinical application is critical to developing new disease-modifying treatments for patients with OA.