Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
基本信息
- 批准号:10425333
- 负责人:
- 金额:$ 51.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-16 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectAnatomyArchitectureArthralgiaBilateralBiochemicalBiomechanicsBone MatrixBone SpurBone TissueBone remodelingCanesCartilageClinicalDataDegenerative polyarthritisDepositionDevelopmentDiagnostic ImagingDiseaseDisease ProgressionDoseEnvironmentExtracellular MatrixFluoride IonFutureGaitHealthHumanHybridsImageImaging DeviceImaging TechniquesImaging technologyInterventionJointsKneeKnee OsteoarthritisKnee jointLateralLongitudinal StudiesMagnetic Resonance ImagingMeasurementMeasuresMechanicsMedialMetabolicMetabolismMethodologyMethodsModelingModificationMorphologyMultimodal ImagingNeeds AssessmentOrthopedicsOsteotomyPainPathogenesisPatientsPerformancePerfusionPhotonsPhysiologyPopulationPositron-Emission TomographyProcessProductivityProtocols documentationQuality of lifeReportingReproducibilityResearchRestRisk FactorsRoentgen RaysSclerosisSeveritiesShapesSocietiesSodium FluorideTechniquesTechnologyTestingThree-Dimensional ImagingTimeTissuesTracerTreatment EfficacyWorkanalysis pipelineattenuationbasebonebone metabolismcartilage metabolismclinical translationcostdeep learningdisabilityefficacy evaluationflexibilitygait examinationgait rehabilitationimaging approachimaging capabilitiesimaging facilitiesimaging modalityimaging systemimprovedinnovationjoint biomechanicsjoint loadingkinetic modelmechanical forcemechanical propertiesmineralizationmolecular markernon-invasive imagingnovelnovel imaging techniquepharmacokinetic modelquantitative imagingradiotracerresponsesoft tissuesubchondral bonetooltreatment strategyuptake
项目摘要
Project Summary
Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to
quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic
resonance imaging (MRI) methods have been proposed for imaging OA, sensitivity to bone metabolism has
been limited. We propose to develop advanced three-dimensional PET-MRI methods for bone and soft tissue
metabolism to study the response of the tissues in the joint to changes in knee load. This work will lead to a new
understanding of OA pathogenesis by revealing relationships between changes in cartilage and bone
metabolism over time.
This project aims to develop PET-MRI methods to sensitively track changes of OA in response to biomechanical
loading. Our specific aims are to (1) Develop accurate, reproducible and dose-optimized kinetic models of
dynamic 18F-NaF PET-MRI for quantitative bilateral whole joint imaging using deep learning and advanced MR
coil technology, (2) Study the relationship between resting state bone metabolism and biomechanics using PET-
MRI and (3) Perform a longitudinal study to assess the response of our new imaging methods to changes in joint
biomechanics from gait retraining.
The innovation of this work lies in the development of novel imaging techniques that simultaneously offer
quantitative measures of tissue physiology in cartilage and bone using PET-MRI. The significance of this work
is that we will be able to sensitively and quantitatively track changes in bone metabolism and soft tissue
microstructure due to changes in biomechanical loading in the knee joint over time. This will provide new and
more sensitive imaging tools to assess the responses of the joint to biomechanical interventions to treat OA such
as gait retraining, bracing, or high tibial osteotomy.
项目总结
项目成果
期刊论文数量(0)
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{{ truncateString('Garry E Gold', 18)}}的其他基金
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
- 批准号:
10202485 - 财政年份:2019
- 资助金额:
$ 51.77万 - 项目类别:
Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis
氟化钠 PET-MRI 定量评估膝骨关节炎的发展
- 批准号:
10659207 - 财政年份:2019
- 资助金额:
$ 51.77万 - 项目类别:
Weight-Bearing Imaging of the Knee Using C-Arm CT
使用 C 臂 CT 进行膝盖负重成像
- 批准号:
9042244 - 财政年份:2015
- 资助金额:
$ 51.77万 - 项目类别:
Weight-Bearing Imaging of the Knee Using C-Arm CT
使用 C 臂 CT 进行膝盖负重成像
- 批准号:
8902732 - 财政年份:2015
- 资助金额:
$ 51.77万 - 项目类别:
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