权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis

氟化钠 PET-MRI 定量评估膝骨关节炎的发展

基本信息

批准号：
10425333
负责人：
Garry E Gold
金额：
$ 51.77万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-16 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10425333
关键词：
3-Dimensional Affect Anatomy Architecture Arthralgia Bilateral Biochemical Biomechanics Bone Matrix Bone Spur Bone Tissue Bone remodeling Canes Cartilage Clinical Data Degenerative polyarthritis Deposition Development Diagnostic Imaging Disease Disease Progression Dose Environment Extracellular Matrix Fluoride Ion Future Gait Health Human Hybrids Image Imaging Device Imaging Techniques Imaging technology Intervention Joints Knee Knee Osteoarthritis Knee joint Lateral Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mechanics Medial Metabolic Metabolism Methodology Methods Modeling Modification Morphology Multimodal Imaging Needs Assessment Orthopedics Osteotomy Pain Pathogenesis Patients Performance Perfusion Photons Physiology Population Positron-Emission Tomography Process Productivity Protocols documentation Quality of life Reporting Reproducibility Research Rest Risk Factors Roentgen Rays Sclerosis Severities Shapes Societies Sodium Fluoride Techniques Technology Testing Three-Dimensional Imaging Time Tissues Tracer Treatment Efficacy Work analysis pipeline attenuation base bone bone metabolism cartilage metabolism clinical translation cost deep learning disability efficacy evaluation flexibility gait examination gait rehabilitation imaging approach imaging capabilities imaging facilities imaging modality imaging system improved innovation joint biomechanics joint loading kinetic model mechanical force mechanical properties mineralization molecular marker non-invasive imaging novel novel imaging technique pharmacokinetic model quantitative imaging radiotracer response soft tissue subchondral bone tool treatment strategy uptake

项目摘要

Project Summary Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, sensitivity to bone metabolism has been limited. We propose to develop advanced three-dimensional PET-MRI methods for bone and soft tissue metabolism to study the response of the tissues in the joint to changes in knee load. This work will lead to a new understanding of OA pathogenesis by revealing relationships between changes in cartilage and bone metabolism over time. This project aims to develop PET-MRI methods to sensitively track changes of OA in response to biomechanical loading. Our specific aims are to (1) Develop accurate, reproducible and dose-optimized kinetic models of dynamic 18F-NaF PET-MRI for quantitative bilateral whole joint imaging using deep learning and advanced MR coil technology, (2) Study the relationship between resting state bone metabolism and biomechanics using PET- MRI and (3) Perform a longitudinal study to assess the response of our new imaging methods to changes in joint biomechanics from gait retraining. The innovation of this work lies in the development of novel imaging techniques that simultaneously offer quantitative measures of tissue physiology in cartilage and bone using PET-MRI. The significance of this work is that we will be able to sensitively and quantitatively track changes in bone metabolism and soft tissue microstructure due to changes in biomechanical loading in the knee joint over time. This will provide new and more sensitive imaging tools to assess the responses of the joint to biomechanical interventions to treat OA such as gait retraining, bracing, or high tibial osteotomy.

项目总结