Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

• 批准号: 10115616
• 负责人: Garry E Gold
• 金额: $ 18.14万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115616
• 关键词: Affect; Area; Award; Biomechanics; Biomedical Engineering; Bone Marrow; Cartilage; Cartilage Matrix; Chemicals; Clinical; Collaborations; Collection; Degenerative polyarthritis; Detection; Development; Diffusion; Discipline; Disease; Disease Progression; Doctor of Philosophy; Electrical Engineering; Engineering; Free Will; Functional disorder; Funding; Glycosaminoglycans; Gold; Human; Human Resources; Image; Imaging Device; Individual; Knee; Lead; Learning; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medical Students; Meniscus structure of joint; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morphology; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; Noise; Orthopedics; Patients; Phase; Physicians; Population; Postdoctoral Fellow; Process; Protocols documentation; Radiology Specialty; Recording of previous events; Relaxation; Reproducibility; Request for Applications; Research; Research Personnel; Resources; Rheumatology; Scanning; Scientist; Signal Transduction; Societies; Sodium; Students; Synovitis; Techniques; Technology; Testing; Thinness; Three-Dimensional Imaging; Time; Training; United States National Institutes of Health; Universities; Wages; Weight-Bearing state; Work; arthropathies; career; cohort; design; early detection biomarkers; effusion; graduate student; imaging biomarker; imaging modality; improved; joint loading; macromolecule; musculoskeletal imaging; new technology; novel; novel strategies; patient oriented research; professor; recruit; temporal measurement; therapy development; undergraduate student

Project Summary / Abstract This is a renewal application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 15 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient-oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both from NIBIB) and recently received an award from NIAMS to use Weight-Bearing CT to study joint loading. Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (50% salary) for 5 years. This funding will guarantee that the candidate will have at least 70% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions.

项目摘要 /摘要 这是针对患者研究（K24）的中级护理研究者奖的续签申请。 申请人Garry Gold博士是医师科学家，放射学，生物工程教授和 斯坦福大学的骨科。在过去的15年中，Gold博士在几个方面发展了专业知识 先进的肌肉骨骼成像和生物力学技术，并将其应用于研究 骨关节炎和关节疾病。这导致他发展了一个独立的以患者为导向的 研究（POR）职业。他获得了使用MR的两个独立研究奖。 研究肌肉骨骼疾病的病理生理学（来自尼比布）和 最近获得了NIAMS的奖励，用于使用承重CT来研究关节载荷。 Gold博士有一个 指导初级临床医生，博士后研究员，医学生的10年历史 研究生和本科生 - 都表现出色。此外，Gold博士还活跃 与肌肉骨骼研究领域的许多由NIH资助的研究人员合作 成像。当前的申请要求5年的资金（50％的薪水）。这笔资金将保证 候选人将至少有70％的保护时间来进行他正在进行的研究和 继续指导临床医生进行POR。该奖项现在将用于空闲时间 行政和临床职责，以更多地关注他的研究和指导活动 接下来的5年。除了从事正在进行的NIH资助的项目外，Gold博士还将获得 高级MR收集和分析方法的其他培训。这将使候选人能够 开发新方法，以适用于肌肉骨骼疾病的成像。给予未偿还的 斯坦福大学的资源和合作，预计这些新型项目将被续签或进行 导致骨科研究的新方向，并为我们的科学做出了重大贡献 了解这些残疾条件。