Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

• 批准号: 10115616
• 负责人: Garry E Gold
• 金额: $ 18.14万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115616
• 关键词: Affect; Area; Award; Biomechanics; Biomedical Engineering; Bone Marrow; Cartilage; Cartilage Matrix; Chemicals; Clinical; Collaborations; Collection; Degenerative polyarthritis; Detection; Development; Diffusion; Discipline; Disease; Disease Progression; Doctor of Philosophy; Electrical Engineering; Engineering; Free Will; Functional disorder; Funding; Glycosaminoglycans; Gold; Human; Human Resources; Image; Imaging Device; Individual; Knee; Lead; Learning; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medical Students; Meniscus structure of joint; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morphology; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; Noise; Orthopedics; Patients; Phase; Physicians; Population; Postdoctoral Fellow; Process; Protocols documentation; Radiology Specialty; Recording of previous events; Relaxation; Reproducibility; Request for Applications; Research; Research Personnel; Resources; Rheumatology; Scanning; Scientist; Signal Transduction; Societies; Sodium; Students; Synovitis; Techniques; Technology; Testing; Thinness; Three-Dimensional Imaging; Time; Training; United States National Institutes of Health; Universities; Wages; Weight-Bearing state; Work; arthropathies; career; cohort; design; early detection biomarkers; effusion; graduate student; imaging biomarker; imaging modality; improved; joint loading; macromolecule; musculoskeletal imaging; new technology; novel; novel strategies; patient oriented research; professor; recruit; temporal measurement; therapy development; undergraduate student

Project Summary / Abstract This is a renewal application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 15 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient-oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both from NIBIB) and recently received an award from NIAMS to use Weight-Bearing CT to study joint loading. Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (50% salary) for 5 years. This funding will guarantee that the candidate will have at least 70% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions.

项目总结/摘要 这是一个以病人为导向的研究（K24）的职业中期研究者奖的续期申请。 申请人Garry Gold博士是一名医生兼科学家，放射学教授，生物工程， 斯坦福大学的整形外科。在过去的15年里，Gold博士在几个领域积累了专业知识。 先进的肌肉骨骼成像和生物力学技术，并将其应用于研究 骨关节炎和关节疾病。这导致他发展了一个独立的以病人为导向的 研究（POR）职业生涯。他已经获得了两个独立的研究奖，从美国国立卫生研究院使用MR 研究肌肉骨骼疾病病理生理学的技术（均来自NIBIB）， 最近获得了NIAMS授予的使用承重CT研究关节载荷的奖项。Gold博士有一个 10-指导初级临床医生科学家，博士后研究员，医学生， 研究生和本科生-都在进行POR。此外，金博士还积极参与 与许多NIH资助的研究人员在肌肉骨骼研究领域的合作， 显像目前的申请要求5年的资金（50%的工资）。这笔资金将保证 候选人将有至少70%的保护时间进行他正在进行的研究， 继续指导临床科学家进行POR。该奖项将腾出时间，现在致力于 行政和临床职责，更专注于他的研究和指导活动， 未来五年。除了正在进行的NIH资助的项目，黄金博士将获得 高级MR收集和分析方法的额外培训。这将使候选人能够 开发新的方法应用于肌肉骨骼疾病的成像。考虑到 在斯坦福大学的资源和合作，这些新的项目预计将被更新或 引导骨科研究的新方向，并为我们的科学研究做出重大贡献。 了解这些禁用条件。