Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis

氟化钠 PET-MRI 定量评估膝骨关节炎的发展

• 批准号: 10659207
• 负责人: Garry E Gold
• 金额: $ 42.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-16 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10659207
• 关键词: 3-Dimensional; Affect; Anatomy; Architecture; Arthralgia; Bilateral; Biochemical; Biomechanics; Bone Matrix; Bone Spur; Bone Tissue; Bone remodeling; Canes; Cartilage; Clinical; Data; Degenerative polyarthritis; Deposition; Development; Diagnostic Imaging; Disease; Disease Progression; Dose; Environment; Extracellular Matrix; Fluoride Ion; Future; Gait; Health; Human; Hybrids; Image; Imaging Device; Imaging Techniques; Imaging technology; Intervention; Joints; Knee; Knee Osteoarthritis; Knee joint; Lateral; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medial; Metabolic; Metabolism; Methodology; Methods; Modeling; Modification; Morphology; Multimodal Imaging; Needs Assessment; Orthopedics; Osteotomy; Pain; Pathogenesis; Patients; Performance; Perfusion; Photons; Physiology; Population; Positron-Emission Tomography; Printing; Process; Productivity; Protocols documentation; Quality of life; Reporting; Reproducibility; Research; Rest; Risk Factors; Roentgen Rays; Sclerosis; Severities; Shapes; Societies; Sodium Fluoride; Structure; System; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Tissues; Tracer; Treatment Efficacy; Work; adduct; analysis pipeline; attenuation; bone; bone metabolism; cartilage metabolism; clinical translation; cost; deep learning; disability; efficacy evaluation; flexibility; gait examination; gait rehabilitation; imaging approach; imaging capabilities; imaging facilities; imaging modality; improved; innovation; joint biomechanics; joint loading; kinetic model; mechanical force; mechanical properties; mineralization; molecular marker; non-invasive imaging; novel; novel imaging technique; pharmacokinetic model; radiotracer; response; soft tissue; subchondral bone; tool; treatment strategy; uptake

Project Summary Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, sensitivity to bone metabolism has been limited. We propose to develop advanced three-dimensional PET-MRI methods for bone and soft tissue metabolism to study the response of the tissues in the joint to changes in knee load. This work will lead to a new understanding of OA pathogenesis by revealing relationships between changes in cartilage and bone metabolism over time. This project aims to develop PET-MRI methods to sensitively track changes of OA in response to biomechanical loading. Our specific aims are to (1) Develop accurate, reproducible and dose-optimized kinetic models of dynamic 18F-NaF PET-MRI for quantitative bilateral whole joint imaging using deep learning and advanced MR coil technology, (2) Study the relationship between resting state bone metabolism and biomechanics using PET- MRI and (3) Perform a longitudinal study to assess the response of our new imaging methods to changes in joint biomechanics from gait retraining. The innovation of this work lies in the development of novel imaging techniques that simultaneously offer quantitative measures of tissue physiology in cartilage and bone using PET-MRI. The significance of this work is that we will be able to sensitively and quantitatively track changes in bone metabolism and soft tissue microstructure due to changes in biomechanical loading in the knee joint over time. This will provide new and more sensitive imaging tools to assess the responses of the joint to biomechanical interventions to treat OA such as gait retraining, bracing, or high tibial osteotomy.

项目摘要 骨关节炎（OA）是全球残疾的主要原因。无创技术无法 量化疾病进展对OA的发病机理的理解有限。而众多磁性 已经提出了用于成像OA的共振成像（MRI）方法，对骨代谢的敏感性具有 受到限制。我们建议开发用于骨骼和软组织的高级三维PET-MRI方法 代谢研究关节中组织对膝关节负荷变化的反应。这项工作将导致新的 通过揭示软骨和骨骼变化之间的关系来理解OA发病机理 随着时间的流逝，代谢。 该项目旨在开发PET-MRI方法，以敏感地跟踪OA的变化，以响应生物力学 加载中。我们的具体目的是（1）开发准确，可重复和剂量优化的动力学模型 动态18F-NAF PET-MRI用于使用深度学习和高级MR的定量双边全关节成像 线圈技术，（2）研究使用PET-的静息状态骨代谢与生物力学之间的关系 MRI和（3）进行纵向研究，以评估我们新成像方法对关节变化的响应 步态再培训的生物力学。 这项工作的创新在于同时提供的新型成像技术的发展 使用PET-MRI的软骨和骨中组织生理的定量测量。这项工作的意义 是我们将能够敏感和定量跟踪骨代谢和软组织的变化 随着时间的推移，膝关节生物力学负荷的变化引起的微观结构。这将提供新的 更敏感的成像工具，以评估关节对生物力学干预措施的反应，以治疗OA 作为步态再训练，支撑或高胫骨截骨术。

项目成果

A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions.

一种用于快速肌肉水 T2 映射的深度学习方法，通过多自旋回波采集进行受试者特定脂肪 T2 校准。

• DOI: 10.1038/s41598-024-58812-2
• 发表时间: 2024
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Barbieri,Marco;Hooijmans,MelissaT;Moulin,Kevin;Cork,TylerE;Ennis,DanielB;Gold,GarryE;Kogan,Feliks;Mazzoli,Valentina
• 通讯作者: Mazzoli,Valentina