Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

• 批准号: 8223332
• 负责人: Garry E Gold
• 金额: $ 15.53万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223332
• 关键词: Affect; Area; Award; Biological Markers; Biomechanics; Biomedical Engineering; Bone Marrow; Cartilage; Cartilage Matrix; Clinical; Collaborations; Collagen; Collection; Cross-Sectional Studies; Data; Degenerative polyarthritis; Detection; Development; Diffusion; Discipline; Disease; Disease Progression; Doctor of Philosophy; Early Diagnosis; Engineering; Free Will; Functional disorder; Funding; Glycosaminoglycans; Gold; Human; Human Resources; Image; Imaging Device; Individual; Lead; Learning; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Mechanics; Medical Students; Meniscus structure of joint; Mentors; Methods; Metric; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal; Musculoskeletal Diseases; National Institute of Biomedical Imaging and Bioengineering; Orthopedics; Osteoarthrosis Deformans; Patients; Physicians; Population; Postdoctoral Fellow; Protocols documentation; Radiology Specialty; Recording of previous events; Relative (related person); Relaxation; Request for Applications; Research; Research Personnel; Resolution; Resources; Rheumatology; Scanning; Scientist; Societies; Sodium; Staging; Students; Synovitis; Techniques; Technology; Testing; Thick; Three-Dimensional Imaging; Time; Training; United States National Institutes of Health; Universities; Wages; Weight; Work; arthropathies; career; design; effusion; graduate student; imaging modality; improved; in vivo; insight; musculoskeletal imaging; novel; novel strategies; patient oriented research; professor; therapy development

DESCRIPTION (provided by applicant): This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions. PUBLIC HEALTH RELEVANCE: Musculoskeletal diseases such as osteoarthritis have a tremendous impact on the individual and society as a whole. We need better imaging tools to detect these diseases at an early, treatable stage. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to improve detection, understanding, and treatment of patients with musculoskeletal disease.

描述（由申请人提供）：这是针对以患者为导向的研究（K24）中的职业生涯中期研究者奖的新申请。申请人 Garry Gold 博士是一位医师兼科学家，也是斯坦福大学放射学、生物工程和骨科副教授。在过去的 10 年里，Gold 博士积累了多种先进肌肉骨骼成像和生物力学技术的专业知识，并将其应用于骨关节炎和关节疾病的研究。这导致他发展了独立的以患者为导向的研究（POR）职业。他获得了 NIH 颁发的两项使用 MR 技术研究肌肉骨骼疾病病理生理学的独立研究奖（均来自 NIBIB）。 Gold 博士拥有 10 年指导初级临床科学家、博士后研究员、医学生、研究生和本科生的历史 - 所有这些都执行 POR。此外，Gold 博士还与许多 NIH 资助的研究人员在肌肉骨骼研究和成像领域积极合作。目前的申请要求资助（40%工资）5年。这笔资金将保证候选人有至少 50% 的受保护时间来进行正在进行的研究，并继续指导执行 POR 的临床科学家。该奖项将使他现在可以腾出时间用于行政和临床职责，以便在未来 5 年内更多地关注他的研究和指导活动。除了从事两个正在进行的 NIH 资助项目外，Gold 博士还将获得高级 MR 采集和分析方法的额外培训。这将使候选人能够开发适用于肌肉骨骼疾病成像的新方法。鉴于斯坦福大学出色的资源和合作，这些新颖的项目预计将得到更新或引领骨科研究的新方向，并为我们的科学理解做出重大贡献 这些禁用条件。 公共卫生相关性：骨关节炎等肌肉骨骼疾病对个人和整个社会产生巨大影响。我们需要更好的成像工具来在早期、可治疗的阶段发现这些疾病。该 K24 奖项将使 PI 能够加大力度指导初级研究人员进行以患者为导向的研究，并开展研究 改善肌肉骨骼疾病患者的检测、了解和治疗。