Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

• 批准号: 8223332
• 负责人: Garry E Gold
• 金额: $ 15.53万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223332
• 关键词: Affect; Area; Award; Biological Markers; Biomechanics; Biomedical Engineering; Bone Marrow; Cartilage; Cartilage Matrix; Clinical; Collaborations; Collagen; Collection; Cross-Sectional Studies; Data; Degenerative polyarthritis; Detection; Development; Diffusion; Discipline; Disease; Disease Progression; Doctor of Philosophy; Early Diagnosis; Engineering; Free Will; Functional disorder; Funding; Glycosaminoglycans; Gold; Human; Human Resources; Image; Imaging Device; Individual; Lead; Learning; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Mechanics; Medical Students; Meniscus structure of joint; Mentors; Methods; Metric; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal; Musculoskeletal Diseases; National Institute of Biomedical Imaging and Bioengineering; Orthopedics; Osteoarthrosis Deformans; Patients; Physicians; Population; Postdoctoral Fellow; Protocols documentation; Radiology Specialty; Recording of previous events; Relative (related person); Relaxation; Request for Applications; Research; Research Personnel; Resolution; Resources; Rheumatology; Scanning; Scientist; Societies; Sodium; Staging; Students; Synovitis; Techniques; Technology; Testing; Thick; Three-Dimensional Imaging; Time; Training; United States National Institutes of Health; Universities; Wages; Weight; Work; arthropathies; career; design; effusion; graduate student; imaging modality; improved; in vivo; insight; musculoskeletal imaging; novel; novel strategies; patient oriented research; professor; therapy development

DESCRIPTION (provided by applicant): This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions. PUBLIC HEALTH RELEVANCE: Musculoskeletal diseases such as osteoarthritis have a tremendous impact on the individual and society as a whole. We need better imaging tools to detect these diseases at an early, treatable stage. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to improve detection, understanding, and treatment of patients with musculoskeletal disease.

描述(由申请人提供)：这是一份新的以患者为中心的职业生涯中期研究人员奖的申请(K24)。申请者Garry Gold博士是一名内科科学家，斯坦福大学放射学、生物工程和整形外科副教授。在过去的10年里，戈尔德博士在几种先进的肌肉骨骼成像和生物力学技术方面积累了专业知识，并将这些技术应用于骨关节炎和关节疾病的研究。这导致他发展了独立的以患者为导向的研究(POR)职业生涯。他获得了美国国立卫生研究院的两项独立研究奖，这两项研究利用磁共振技术研究肌肉骨骼疾病的病理生理学(两者都来自NIBIB)。戈尔德博士有10年指导初级临床医生科学家、博士后研究员、医学生、研究生和本科生的历史--所有人都在进行POR。此外，戈尔德博士还与NIH资助的许多研究人员在肌肉骨骼研究和成像领域进行了积极的合作。目前的申请要求提供为期5年的资金(40%工资)。这笔资金将保证候选人将有至少50%的保护时间来进行他正在进行的研究，并继续指导进行POR的临床医生科学家。这一奖项将腾出现在专门用于行政和临床责任的时间，以便在未来5年更多地专注于他的研究和指导活动。除了参与美国国立卫生研究院正在进行的两个项目外，戈尔德博士还将接受高级磁共振采集和分析方法方面的额外培训。这将使候选人能够开发新的方法来应用于肌肉骨骼疾病的成像。鉴于斯坦福大学出色的资源和合作，这些新颖的项目有望得到更新或引领整形外科研究的新方向，并对我们的科学理解做出重大贡献 这些致残条件。 公共卫生相关性：骨关节炎等肌肉骨骼疾病对个人和整个社会都有巨大影响。我们需要更好的成像工具，以便在早期、可治疗的阶段发现这些疾病。这一K24奖项将允许PI在指导初级调查人员以患者为导向的研究方面做出更大努力，并进行研究 提高对肌肉骨骼疾病患者的发现、了解和治疗水平。