Advanced MR Imaging of Early Osteoarthritis

描述（由申请人提供）：这是一个新的应用程序的中期职业生涯研究者奖以患者为导向的研究（K24）。申请人Garry Gold博士是斯坦福大学放射学、生物工程学和骨科副教授。在过去的10年里，Gold博士在几种先进的肌肉骨骼成像和生物力学技术方面积累了专业知识，并将其应用于骨关节炎和关节疾病的研究。这使他发展了一个独立的以病人为导向的研究（POR）事业。他获得了NIH的两项独立研究奖，这些研究奖使用MR技术研究肌肉骨骼疾病的病理生理学（均来自NIBIB）。Gold博士有10年的指导初级临床科学家、博士后研究员、医学生、研究生和本科生的历史-所有人都进行POR。此外，Gold博士与许多NIH资助的研究人员在肌肉骨骼研究和成像领域积极合作。目前的申请要求5年的资金（40%的工资）。这笔资金将保证候选人将有至少50%的保护时间来进行他正在进行的研究，并继续指导临床科学家进行POR。该奖项将腾出时间，现在致力于行政和临床责任，更专注于他的研究和指导活动，在未来5年。除了从事两个正在进行的NIH资助的项目外，Gold博士还将获得先进的MR收集和分析方法的额外培训。这将使候选人能够开发新的方法来应用于肌肉骨骼疾病的成像。鉴于斯坦福大学的杰出资源和合作，这些新项目有望得到更新或导致骨科研究的新方向，并为我们的科学理解做出重大贡献 这些残疾人的条件。 公共卫生相关性：骨关节炎等肌肉骨骼疾病对个人和整个社会产生巨大影响。我们需要更好的成像工具，以便在早期可治疗的阶段发现这些疾病。该K24奖项将允许PI在以患者为导向的研究中加强对初级研究者的指导，并开展研究 提高对肌肉骨骼疾病患者的检测、理解和治疗。

DESCRIPTION (provided by applicant): This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions. PUBLIC HEALTH RELEVANCE: Musculoskeletal diseases such as osteoarthritis have a tremendous impact on the individual and society as a whole. We need better imaging tools to detect these diseases at an early, treatable stage. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to improve detection, understanding, and treatment of patients with musculoskeletal disease.