Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

• 批准号: 8223332
• 负责人: Garry E Gold
• 金额: $ 15.53万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223332
• 关键词: Affect; Area; Award; Biological Markers; Biomechanics; Biomedical Engineering; Bone Marrow; Cartilage; Cartilage Matrix; Clinical; Collaborations; Collagen; Collection; Cross-Sectional Studies; Data; Degenerative polyarthritis; Detection; Development; Diffusion; Discipline; Disease; Disease Progression; Doctor of Philosophy; Early Diagnosis; Engineering; Free Will; Functional disorder; Funding; Glycosaminoglycans; Gold; Human; Human Resources; Image; Imaging Device; Individual; Lead; Learning; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Mechanics; Medical Students; Meniscus structure of joint; Mentors; Methods; Metric; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal; Musculoskeletal Diseases; National Institute of Biomedical Imaging and Bioengineering; Orthopedics; Osteoarthrosis Deformans; Patients; Physicians; Population; Postdoctoral Fellow; Protocols documentation; Radiology Specialty; Recording of previous events; Relative (related person); Relaxation; Request for Applications; Research; Research Personnel; Resolution; Resources; Rheumatology; Scanning; Scientist; Societies; Sodium; Staging; Students; Synovitis; Techniques; Technology; Testing; Thick; Three-Dimensional Imaging; Time; Training; United States National Institutes of Health; Universities; Wages; Weight; Work; arthropathies; career; design; effusion; graduate student; imaging modality; improved; in vivo; insight; musculoskeletal imaging; novel; novel strategies; patient oriented research; professor; therapy development

DESCRIPTION (provided by applicant): This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions. PUBLIC HEALTH RELEVANCE: Musculoskeletal diseases such as osteoarthritis have a tremendous impact on the individual and society as a whole. We need better imaging tools to detect these diseases at an early, treatable stage. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to improve detection, understanding, and treatment of patients with musculoskeletal disease.

描述（由申请人提供）：这是一份面向患者研究（K24）的职业中期研究者奖的新申请。申请人Garry Gold博士是斯坦福大学放射学、生物工程和骨科副教授，是一名内科科学家。在过去的10年里，Gold博士在几个先进的肌肉骨骼成像和生物力学技术方面发展了专业知识，并将这些技术应用于骨关节炎和关节疾病的研究。这导致他发展了一个独立的以病人为导向的研究（POR）事业。他获得了两项由美国国立卫生研究院颁发的独立研究奖，这两项研究使用磁共振技术来研究肌肉骨骼疾病的病理生理学（均来自NIBIB）。Gold博士有10年指导初级临床科学家、博士后研究员、医学院学生、研究生和本科生的经验，他们都表现得很差。此外，Gold博士在肌肉骨骼研究和成像领域与许多美国国立卫生研究院资助的研究人员积极合作。目前的申请要求5年的资金（40%的工资）。这笔资金将保证候选人至少有50%的保护时间来进行他正在进行的研究，并继续指导临床科学家进行POR。获得该奖项后，他将在未来5年内将更多的时间用于行政和临床工作，以专注于他的研究和指导活动。除了在两个正在进行的nih资助项目中工作，Gold博士还将获得高级MR收集和分析方法的额外培训。这将允许候选人开发新的方法，适用于肌肉骨骼疾病的成像。鉴于斯坦福大学的优秀资源和合作，这些新颖的项目有望在骨科研究中得到更新或引领新的方向，并为我们的科学理解做出重大贡献