Population-based Cohort of Endometrial Cancer Survivors in Utah

犹他州基于人群的子宫内膜癌幸存者队列

基本信息

批准号：
8814097
负责人：
MIA HASHIBE
金额：
$ 19.44万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-12 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8814097
关键词：
Address Age Area Behavior Birth Certificates Body Weight decreased Cancer Patient Cancer Survivor Cancer Survivorship Cardiotoxicity Cardiovascular Diseases Cessation of life Characteristics Chronic Cognitive deficits Colorectal Cancer Comorbidity Computerized Medical Record Data Data Linkages Databases Diagnosis Disease Distress Educational workshop Endometrial Carcinoma Epidemiologic Studies Exercise Family Fatigue Female Foundations Future Health Healthcare Healthcare Systems Hospitals Incidence Individual Intervention Late Effects Licensing Link Long-Term Effects Malignant Childhood Neoplasm Malignant Neoplasms Malignant neoplasm of prostate Malignant neoplasm of testis Medical Records Medicare Modality National Cancer Institute Osteoporosis Patient Self-Report Patients Pilot Projects Population Population Database Questionnaires Radiation therapy Recording of previous events Records Registries Relative Risks Reporting Research Research Design Research Infrastructure Research Priority Resources Risk Sampling Scandinavian Second Primary Cancers Sexual Dysfunction and Infertility Source Survival Rate Survivors Time Toxic effect United States Utah Voting Woman Work base cancer diagnosis cancer site cancer therapy cancer type chemotherapy chronic depression chronic pain cohort comparison group cost follow-up fundamental research health record lifestyle factors malignant breast neoplasm meetings neoplasm registry neurotoxicity population based public health relevance

项目摘要

DESCRIPTION (provided by applicant): Endometrial cancer is the second most common cancer among female cancer survivors in the United States. There are an estimated 600,000 endometrial cancer survivors today. Additionally, 49,560 incident endometrial cancer cases are diagnosed each year. Endometrial cancer has been identified by the NCI as an understudied cancer site and late effects research on endometrial cancer patients is very limited to our knowledge. Late effects are of concern among cancer patients due to the toxic effects of chemotherapy and radiotherapy. Specific late effects of concern include second primary cancers, osteoporosis, cardio-toxicity, neuro-toxicity, cognitive deficits, depression, chronic fatigue, chronic pain, infertility and sexual dysfunction. The Utah Population Database (UPDB) provides a unique and excellent resource for epidemiologic research, and links data from the Utah Cancer Registry, hospital electronic medical records, Medicare, driver licenses, voter registration, family history records, and birth certificates. We have successfully completed a study of late effects of 1,001 testicular cancer patients with the same study design (93.2% successfully followed up through the EMR). Within the UPDB linked data with the Utah Cancer Registry, we propose to construct a population- based endometrial cancer patient cohort covering the state of Utah. Our specific aims are: (1) To assemble a population-based cohort of 3,400 endometrial cancer patients and 17,000 age-matched cancer-free women for a comparison group, to investigate the incidence of long-term health effects due to endometrial cancer treatment, (2) To assess the feasibility of administering questionnaires to assess lifestyle factors in a sample of the endometrial cancer survivors (n=500) and cancer-free women for a comparison group (n=500), (3) To determine the feasibility of collecting detailed cancer treatment information such as chemotherapy agents from medical records by conducting medical record abstraction among a sample of endometrial cancer patients (n=200), (4) To compare the quality of information obtained from the existing records and the self-report from the questionnaire on late effects, comorbidities, and cancer treatment (n=1,000). The aim 1 late effects analysis is based on existing data (linkage of cancer registry and EMR) and we are able to obtain late effects information on >90% of cancer patients in Utah. Our project addresses the priority research areas highlighted by the NCI: assessment of late effects, study of survivors with comorbidities, and focusing on an understudied cancer. We will assemble an unprecedented high-quality population-based cohort of 3,400 endometrial cancer patients to study late effects for the first time, at a very low cost due to existing linked databases within te UPDB. This application will also lay important foundation work for a future large-scale population-based endometrial cancer survivorship project. Understanding the long-term effects of cancer treatment and their determinants will be extremely valuable for the 600,000 endometrial cancer survivors and the 49,560 women who will be diagnosed this year.

描述（由适用提供）：子宫内膜癌是美国女性癌症存活中第二常见的癌症。如今，估计有600,000个子宫内膜癌的存活。此外，每年诊断出49,560例发生的子宫内膜癌病例。 NCI已将子宫内膜癌鉴定为一种理解的癌症部位，对子宫内膜癌患者的后期作用研究非常限于我们的知识。由于化学疗法和放射疗法的毒性作用，癌症患者的后期作用引起了人们的关注。关注的特定后期作用包括第二个原发性癌症，骨质疏松症，心脏毒性，神经毒性，认知定义，抑郁症，慢性疲劳，慢性疼痛，不育和性功能障碍。犹他州人口数据库（UPDB）为流行病学研究提供了独特而出色的资源，并将犹他州癌症注册中心，医院电子病历，医疗保险，驾驶执照，选民注册，家族史记录和出生证明的数据联系起来。我们已经成功完成了对1,001例具有相同研究设计的癌症患者的后期作用（93.2％的人通过EMR成功跟踪）。在UPDB的数据与犹他州癌症登记册相关联之内，我们建议构建一个涵盖犹他州的基于人群的子宫内膜癌患者队列。我们的具体目的是：（1）组装3,400例子宫内膜癌患者和17,000名与比较组的无癌女性的同类同类，以调查子宫内膜癌治疗引起的长期健康影响的事件（2）评估评估生物inairs量的可行性，以评估生活方式的可行性。比较组（n = 500）的子宫内膜癌存活样本（n = 500）和无癌女性的因素（3），以确定收集详细的癌症治疗信息（例如从医疗记录中的化学治疗剂）通过对内膜癌患者进行医学记录进行的详细癌症治疗信息（n = 200）（4）（4）的可行性（4），（4）（4）（4）影响，合并症和癌症治疗（n = 1,000）。 AIM 1后期效应分析基于现有数据（癌症注册表和EMR的联系），我们能够获取犹他州> 90％的癌症患者的后期效应信息。我们的项目解决了NCI突出显示的优先研究领域：评估后期影响，合并症的生存研究以及专注于理解的癌症。我们将组装一个前所未有的高质量基于人群的队列，其中3,400名子宫内膜癌患者首次研究延迟效果，这是由于TE UPDB中现有的链接数据库而产生的非常低的成本。该应用程序还将为未来的大规模基于人群的子宫内膜癌症生存项目奠定重要的基础工作。了解癌症治疗及其决定者的长期影响对于600,000个子宫内膜癌症生存以及今年将被诊断出的49,560名妇女非常有价值。