Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption

描述：Emory ACE加入了3个机构的8个实验室，从一开始就创建了一个临床和转化科学中心，以期对社区产生革命性的影响。马库斯自闭症中心、埃默里大学医学院和耶克斯国家灵长类动物研究中心的实验室结合了儿童发展、行为神经科学、言语科学、分子遗传学和治疗研究方面的方法学和概念性专业知识；所有这些都是在全市范围内发起的自闭症研究倡议的背景下进行的，该倡议由全国最大的儿科医疗保健系统亚特兰大儿童保健推动。Emory ACE的主题使命指导着它的5个项目和4个核心：揭开自闭症谱系障碍风险和复原力的发育复杂性，以便我们可以推进针对儿童的最有效和最成功的治疗。项目I和II量化了社会视觉(PI)和社会声音(PLL)的发展 参与，从出生到24个月大，以确定积极结果的概况以及残疾的风险因素。项目III推进了严格的随机对照试验，以治疗婴儿期和蹒跚学步的自闭症，测试社会参与的发展轨迹(项目I和II)预测治疗反应和结果的程度。也是从婴儿期开始的。项目IV和V建立了一个非人类灵长类动物模型，用于研究社会残疾在基因、大脑和行为方面的基础，以规范社会发展(PV)及其破坏的遗传手段(PIV)。这些项目共同推进了我们对自闭症发展过程的理解，并为在残疾甚至完全显现之前改变自闭症的进程奠定了基础。四个核心提供支持这些目标的资源，包括评估、信息学、管理和培训。在努力达到和超过NIH机构间自闭症协调委员会(LACC)为自闭症设定的理想目标的过程中，Emory ACE创建了一个新的科学社区，专注于自闭症谱系障碍的翻译社会神经科学，为儿童和家庭服务。

DESCRIPTION: The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research; all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system in the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatmnt of ASD into infancy and toddlerhood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V establish-for normative social development (PV) and a genetic means to its disruption (PIV)-a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.