Development of small molecule modulators of apoptosis

细胞凋亡小分子调节剂的开发

• 批准号: nhmrc : 1025138
• 负责人: A/Pr Guillaume Lessene
• 金额: $ 41.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-small-molecule-modulators-apoptosis/110407
• 关键词: Development; small; molecule; modulators; apoptosis

Cancers rely on the deregulation of key cellular pathways. Along with biological and genetic tools, small molecules are powerful probes to understand these mechanisms. During the course of this research program, we will develop new and drug-like molecules that reinstate the cell death process to combat malignancies. This research will bring important advances for potential chemotherapies and create probes to better understand the biology of programmed cell death processes.

癌症依赖于对关键细胞通路的放松管制。与生物和遗传工具一样，小分子是理解这些机制的强大探测器。在这项研究计划的过程中，我们将开发新的类似药物的分子，恢复细胞死亡过程，以对抗恶性肿瘤。这项研究将为潜在的化疗带来重要进展，并创造更好地理解程序性细胞死亡过程的生物学的探针。