Small molecule apoptosis inhibitors to define the Bak activating switch

小分子凋亡抑制剂定义 Bak 激活开关

• 批准号: nhmrc : 1083077
• 负责人: A/Pr Guillaume Lessene
• 金额: $ 47.59万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/small-molecule-apoptosis-activating-switch/518909
• 关键词: Small; molecule; apoptosis; inhibitors; define

Tissue loss due to excessive apoptosis is a contributing factor to organ transplant failure and other diseases characterised by too much cell death. Using an innovative cell-based screening approach, we have identified a first in class series of molecules that potently block cell death driven by the apoptosis effector Bak. By unravelling the molecular target of our unique inhibitors and characterising their mode of action, we hope to uncover a new facet of Bax and Bak biology.

由于过度凋亡导致的组织损失是器官移植失败和其他以过多细胞死亡为特征的疾病的促成因素。使用一种创新的基于细胞的筛选方法，我们已经确定了第一类系列的分子，有效地阻止细胞凋亡效应巴克驱动的细胞死亡。通过解开我们独特的抑制剂的分子靶点并表征其作用模式，我们希望揭示Bax和巴克生物学的新方面。