Chemical and structural biology validation of Lamin B1 as a new anti-cancer target

Lamin B1 作为新抗癌靶点的化学和结构生物学验证

• 批准号: nhmrc : 1057805
• 负责人: A/Pr Guillaume Lessene
• 金额: $ 42.56万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chemical-structural-biology-cancer-target/454632
• 关键词: Chemical; structural; biology; validation; Lamin

The validation of new anti-cancer targets is critical for the development of new therapies. We have discovered a small molecule that disrupt the function Lamin B1 during cell division and decreases tumour growth significantly in vivo. With this research proposal, we will investigate the role that Lamin B1 exerts during cell division and why interfering with this protein has such a profound impact on cancer cells.

新的抗癌靶点的验证对于新疗法的发展至关重要。我们已经发现了一个小分子，它在细胞分裂过程中破坏层蛋白B1的功能，并在体内显著降低肿瘤的生长。通过这项研究计划，我们将研究Lamin B1在细胞分裂过程中发挥的作用，以及为什么干扰该蛋白对癌细胞有如此深远的影响。