To investigate the role of ATM protein in protecting against neurodegeneration
To investigate the role of ATM protein in protecting against neurodegeneration
批准号:
nhmrc : GNT1077989
负责人:
Dr Mark Graham
金额:
$92.08万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 --
中文摘要
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英文摘要
The overall aim of the project is to employ a rat model to investigate neurodegeneration in patients with ataxia-telangiectasia (A-T). Ataxia-telangiectasia is a complex multisystem disorder characterised by progressive neurological impairment, variable immunodeficiency and cancer predisposition. The rat model recapitulates the neurodegeneration in patients and thus this project will provide important insight into the nature of the defect as well as approaches for the treatment of the disorder.
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To investigate the role of ATM protein in protecting against neurodegeneration
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批准号:nhmrc : 1077989
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项目类别:Project Grants
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资助金额:$63.59万
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财政年份:2015
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负责人:Dr Mark Graham
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依托单位:
Phosphatase regulators mediate long-term changes in presynaptic terminals
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批准号:nhmrc : 1079160
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项目类别:Project Grants
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资助金额:$65.62万
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财政年份:2015
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负责人:Dr Mark Graham
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依托单位:
Phosphatase regulators mediate long-term changes in presynaptic terminals
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批准号:nhmrc : GNT1079160
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项目类别:Project Grants
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资助金额:$94.28万
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财政年份:2015
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负责人:Dr Mark Graham
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依托单位:
Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission
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批准号:nhmrc : 1052494
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项目类别:Project Grants
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资助金额:$40.9万
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财政年份:2013
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负责人:Dr Mark Graham
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依托单位:
Role of oxidative stress in activating ATM to protect against neurodegeneration
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批准号:nhmrc : 1019996
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项目类别:Project Grants
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资助金额:$38.03万
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财政年份:2012
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负责人:Dr Mark Graham
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依托单位:
ATM Activation and its functional Importance in DNA damage response
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批准号:nhmrc : 569591
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项目类别:NHMRC Project Grants
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资助金额:$37.04万
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财政年份:2009
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负责人:Dr Mark Graham
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依托单位:
Mechanisms of synaptic vesicle endocytosis revealed by its regulatory phosphoproteome
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批准号:nhmrc : 571070
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项目类别:NHMRC Project Grants
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资助金额:$36.36万
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财政年份:2009
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负责人:Dr Mark Graham
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依托单位:
Inhibitory signalling switches define the machinery of synaptic vesicle endocytosis
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批准号:nhmrc : 531700
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项目类别:Career Development Fellowships
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资助金额:$25.84万
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财政年份:2009
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负责人:Dr Mark Graham
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依托单位:
O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling.
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批准号:DP0987706
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项目类别:Discovery Projects
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资助金额:$20.8万
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财政年份:2009
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负责人:Dr Mark Graham
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依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
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批准号:82372275
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:刘耀宝
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依托单位:
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
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批准号:82371070
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:赵培泉
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依托单位: