O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling.

O-GlcNAc-磷酸化：一种调节囊泡回收的新型翻译后修饰。

• 批准号: DP0987706
• 负责人: Dr Mark Graham
• 金额: $ 20.8万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-30 至 2013-03-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987706
• 关键词: GlcNAc; phosphorylation; novel; post; translational

We will determine a biological role for our discovery of a hybrid protein modification (both carbohydrate and phosphate) on a brain protein that is involved in nerve cell communication. If this modification is more widespread, then we will have discovered a new level of cellular regulation. This discovery is likely to have a broad benefit. It will advance the understanding of carbohydrate and phosphate modified proteins. For example, there may be consequences for the model of hyperphosphorylated and carbohydrate modified proteins involved in neurodegeneration. There will also be a targeted benefit. An improved understanding of the mechanism of neurotransmission will benefit in designing compounds to fight diseases of neurotransmission.

我们将确定我们发现的一种混合蛋白质修饰（碳水化合物和磷酸盐）对参与神经细胞通讯的脑蛋白质的生物学作用。如果这种修饰更广泛，那么我们将发现一种新的细胞调节水平。这一发现可能会带来广泛的好处。这将促进对碳水化合物和磷酸盐修饰蛋白质的理解。例如，对于参与神经变性的过度磷酸化和碳水化合物修饰的蛋白质的模型，可能存在后果。也会有针对性的好处。对神经传递机制的进一步理解将有助于设计用于对抗神经传递疾病的化合物。