To investigate the role of ATM protein in protecting against neurodegeneration

研究 ATM 蛋白在预防神经退行性变中的作用

• 批准号: nhmrc : 1077989
• 负责人: Dr Mark Graham
• 金额: $ 63.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigate-role-atm-protecting-neurodegeneration/518545
• 关键词: investigate; role; ATM; protein; protecting

The overall aim of the project is to employ a rat model to investigate neurodegeneration in patients with ataxia-telangiectasia (A-T). Ataxia-telangiectasia is a complex multisystem disorder characterised by progressive neurological impairment, variable immunodeficiency and cancer predisposition. The rat model recapitulates the neurodegeneration in patients and thus this project will provide important insight into the nature of the defect as well as approaches for the treatment of the disorder.

该项目的总体目标是采用大鼠模型来研究共济失调-毛细血管扩张（a-t）患者的神经退行性变。共济失调毛细血管扩张症是一种复杂的多系统疾病，其特征是进行性神经功能障碍、可变免疫缺陷和癌症易感性。大鼠模型概括了患者的神经变性，因此该项目将为了解缺陷的本质以及治疗该疾病的方法提供重要的见解。