Mechanisms of synaptic vesicle endocytosis revealed by its regulatory phosphoproteome

调节性磷酸蛋白质组揭示突触小泡内吞作用的机制

• 批准号: nhmrc : 571070
• 负责人: Dr Mark Graham
• 金额: $ 36.36万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-synaptic-vesicle-regulatory-phosphoproteome/80811
• 关键词: Mechanisms; synaptic; vesicle; endocytosis; revealed

The nerve cells in our brains are in constant communication to sustain life. Communication involves electrical stimulation of one nerve cell which then responds by releasing chemical messengers, from vesicles, onto the next cell. Our research focuses on the mechanism of recycling of vesicles. Targeting this mechanism is a way to gain fundamental knowledge of how to intervene medically when communication fails, or when communication needs to be dampened, such as in some neurological diseases.

我们大脑中的神经细胞不断交流以维持生命。通讯包括电刺激一个神经细胞，然后通过释放化学信使，从囊泡到下一个细胞。我们的研究重点是囊泡的再循环机制。针对这一机制是一种获得基本知识的方法，即当沟通失败时，或者当沟通需要被抑制时，例如在某些神经系统疾病中，如何进行医学干预。