Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission

突触小泡糖蛋白 2 (SV2) 的磷酸化调节突触结合蛋白的内吞作用以实现突触传递

• 批准号: nhmrc : 1052494
• 负责人: Dr Mark Graham
• 金额: $ 40.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phosphorylation-synaptic-vesicle-synaptic-transmission/112278
• 关键词: Phosphorylation; synaptic; vesicle; glycoprotein; SV2

Antiepileptic drugs typically target ion transporters or neurotransmitter receptors. Synaptic vesicle glycoprotein 2 (SV2) is a rare example of a synaptic vesicle recycling protein that is the target of an antiepileptic drug. It also binds botulinum and tetanus neurotoxins. We discovered SV2 contains activity-dependent signalling molecules. Charactersation of these molecules and will allow a deeper understanding of the molecular basis for its role in epilepsy and toxin action.

抗癫痫药物通常靶向离子转运蛋白或神经递质受体。突触囊泡糖蛋白2（SV2）是一种罕见的突触囊泡回收蛋白，是抗癫痫药物的目标。它还结合肉毒杆菌和破伤风神经毒素。我们发现SV2含有活性依赖性信号分子。这些分子的分离将使我们更深入地了解其在癫痫和毒素作用中作用的分子基础。