Feasibility of in vivo longitudinal micro-CT studies

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Micro-computed tomography (micro-CT) has rapidly become an important laboratory tool for studies of human disease in rodent models. Like computed tomography (CT) scans performed in radiology departments on human subjects, micro-CT scanners use x-ray images acquired at different angles around the subject to produce high quality, 3D images of the anatomy. However, micro-CT scanners are highly specialized to provide high-resolution images of the small structures inside rodents, such as the branching airways in the lungs, or the vessels bringing oxygen and nutrients to a tumour.