MALDI-TOF mass spectrometer for biomolecule characterization

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The aim of this proposal is to acquire matrix assisted laser desorption ionization (MALDI) mass spectrometry for biological macromolecule characterization in the departments of Chemistry, Physics, Chemical and Biological Engineering, and Biochemistry, Microbiology and Immunology. Mass spectrometry based characterization of biomolecules is a key experimental technique required for a growing number of interdisciplinary research programs, including those in bioanalytical chemistry, chemical biology, biomaterials and biotechnology. The requested MALDI mass spectrometer is a robust, versatile linear time-of-flight (TOF) system that can be used to determine mass to charage ratios for macromolecules up to 500,000 Daltons. Beyond its important impact on the specific research programs described below, acquisition of this MALDI-TOF system will enhance interdisciplinary research and training efforts in the diverse biomolecular sciences community at the University of Ottawa.