A framework for the in silico modeling and investigation of time dependent photobiophysical phenomena

时间依赖性光生物物理现象的计算机建模和研究框架

• 批准号: 238337-2010
• 负责人: Baranoski, Gladimir
• 金额: $ 1.46万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=508055
• 关键词: framework; silico; modeling; investigation; time

The predictive assessment of the beneficial and harmful effects of light (radiation) incidence on plant and human tissues, from photosynthesis to the development of cancer, is of fundamental importance since it can be used to improve the quality of human and animal life and to provide alternatives for environmental problems on a global scale. The purpose of this research program is to break new ground toward such an assessment. It will expand the boundaries of realistic image synthesis through the predictive simulation of time dependent photobiophysical phenomena responsible for appearance changes in natural materials. Skin related processes, such as tanning, aging and lesion formation, triggered by ultraviolet radiation are examples of such phenomena. In these cases, the simulation of appearance changes may be used to assist the prevention, diagnosis and treatment of skin diseases. Color changes observed in plant leaves under nutrient and water stress are also examples of such phenomena. In these cases, "virtual" experiments can provide reliable feedback with respect to different agricultural strategies that can be applied to cope with these adverse conditions and improve crop production. Once a computer simulation framework is designed and validated through a sound scientific methodology, as proposed in this research program, it can be employed in the "in silico" investigation of phenomena that cannot be fully studied through traditional experimental procedures. Accordingly, it can be used to assist in the hypothesis generation and validation cycles of research in different scientific domains. Hence, the proposed simulation framework will contribute to interdisciplinary research efforts in fields such as biomedical optics, biophysical dermatology and remote sensing, in addition to fundamental contributions to computer graphics through the design of predictive algorithms for the generation of realistic images depicting time dependent appearance changes, Furthermore, this research program may lead to the emergence of innovative technologies (e.g., new devices for the noninvasive diagnostic of medical conditions) as well as the establishment of government policies for ecological issues and testing protocols for new protective materials.

预测评估光（辐射）入射对植物和人体组织（从光合作用到癌症的发展）的有益和有害影响具有根本重要性，因为它可用于改善人类和动物的生活质量，并为全球范围的环境问题提供替代方案。这项研究计划的目的是为这种评估开辟新天地。它将通过预测模拟导致自然材料外观变化的时间相关光生物物理现象来扩展真实图像合成的边界。由紫外线辐射触发的皮肤相关过程，例如晒黑、老化和损伤形成是这种现象的实例。 在这些情况下，外观变化的模拟可用于辅助皮肤疾病的预防、诊断和治疗。在营养和水分胁迫下观察到的植物叶片颜色变化也是这种现象的例子。在这些情况下，“虚拟”实验可以提供可靠的反馈，说明可用于科普这些不利条件和提高作物产量的不同农业战略。一旦一个计算机模拟框架的设计和验证，通过一个健全的科学方法，如本研究计划中提出的，它可以在“在硅片”的现象，不能通过传统的实验程序充分研究的调查。因此，它可以用来帮助在不同的科学领域的研究的假设生成和验证周期。因此，所提出的模拟框架将有助于生物医学光学、生物物理皮肤病学和遥感等领域的跨学科研究工作，此外还将通过设计用于生成描绘随时间变化的外观变化的逼真图像的预测算法对计算机图形学做出根本性贡献。非侵入性医疗诊断的新设备），以及制定政府生态问题政策和新防护材料测试协议。