Plasma Enhanced CVD System for Polymer Coating Deposition on Tubular Tiny Medical Devices
用于管状微型医疗器械上聚合物涂层沉积的等离子体增强 CVD 系统
基本信息
- 批准号:440005-2013
- 负责人:
- 金额:$ 10.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Research Tools and Instruments - Category 1 (<$150,000)
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cardiovascular stents are small devices inserted into blood vessels to prevent localized flow restriction due to vascular diseases. Unfortunately, failure or clinical complications are often observed with the current commercial devices. Therefore, the proposed project focuses on designing an innovative functional material for surface modification of stents. Furthermore, the process is designed to be easily transferable to a number of biomedical applications where functional coatings seek to improve clinical performances. More precisely, our aim is to design surface modifications allowing the development of polymer-based highly adherent and cohesive nano-coatings for stents. Polymer coatings are potential solutions for locally controlled drug release and they can also act as barrier for potentially toxic metallic ions release by metallic stents. Moreover, they can be used as carriers to graft biomolecules that are largely studied to improve the interaction of materials with the biological system. A challenging task is to coat materials with complex geometries like stents and to determine their mechanical and biological performances. Overall, these new nano-coatings should contribute to improve the clinical performances of stents and therefore impact positively the quality and cost of healthcare in Canada and around the globe.
心血管支架是插入血管中以防止由于血管疾病引起的局部流动限制的小装置。不幸的是,目前的商业设备经常观察到故障或临床并发症。因此,本项目的重点是设计一种用于支架表面改性的创新功能材料。此外,该工艺的设计可轻松转移到许多生物医学应用中,其中功能涂层旨在改善临床性能。更确切地说,我们的目标是设计表面改性,允许开发用于支架的聚合物基高粘附性和内聚性纳米涂层。聚合物涂层是局部控制药物释放的潜在解决方案,它们还可以作为金属支架释放潜在有毒金属离子的屏障。此外,它们可以用作载体来接枝生物分子,这些生物分子被大量研究以改善材料与生物系统的相互作用。一项具有挑战性的任务是涂覆具有复杂几何形状的材料,如支架,并确定其机械和生物性能。总的来说,这些新的纳米涂层应有助于改善支架的临床性能,从而对加拿大和地球仪的医疗保健质量和成本产生积极影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mantovani, Diego其他文献
Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery.
- DOI:
10.3390/molecules27217271 - 发表时间:
2022-10-26 - 期刊:
- 影响因子:4.6
- 作者:
De Sousa Sabino, Luiz Bruno;Copes, Francesco;Saulais, Solene;De Brito, Edy Sousa;Da Silva Junior, Ivanildo Jose;Le, Tien Canh;Mateescu, Mircea Alexandru;Mantovani, Diego - 通讯作者:
Mantovani, Diego
A comparison of adsorbed and grafted fibronectin coatings under static and dynamic conditions
- DOI:
10.1039/c6cp04527h - 发表时间:
2016-01-01 - 期刊:
- 影响因子:3.3
- 作者:
Montano-Machado, Vanessa;Hugoni, Ludivine;Mantovani, Diego - 通讯作者:
Mantovani, Diego
Effects of solar radiation on collagen-based biomaterials
- DOI:
10.1155/ijp/2006/29196 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:3.2
- 作者:
Sionkowska, Alina;Wisniewski, Marcin;Mantovani, Diego - 通讯作者:
Mantovani, Diego
On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process
- DOI:
10.1116/1.4871435 - 发表时间:
2014-06-01 - 期刊:
- 影响因子:2.1
- 作者:
Cloutier, Maxime;Tolouei, Ranna;Mantovani, Diego - 通讯作者:
Mantovani, Diego
Viscoelastic properties of multi-layered cellularized vascular tissues fabricated from collagen gel
- DOI:
10.1016/j.jmbbm.2018.01.021 - 发表时间:
2018-04-01 - 期刊:
- 影响因子:3.9
- 作者:
Seifu, Dawit G.;Meghezi, Sebastien;Mantovani, Diego - 通讯作者:
Mantovani, Diego
Mantovani, Diego的其他文献
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{{ truncateString('Mantovani, Diego', 18)}}的其他基金
Biomatériaux et Bioingénierie pour l'Innovation en Chirurgie/Biomaterials and Bioengineering for the Innovation in Surgery
Biomatäriaux et Bioingänierie pour lInnovation en Chirurgie/生物材料和生物工程促进外科创新
- 批准号:
CRC-2018-00091 - 财政年份:2022
- 资助金额:
$ 10.91万 - 项目类别:
Canada Research Chairs
Designing, developing and validating advanced materials and surface modifications for innovative biomaterials and implants
设计、开发和验证创新生物材料和植入物的先进材料和表面改性
- 批准号:
RGPIN-2022-04179 - 财政年份:2022
- 资助金额:
$ 10.91万 - 项目类别:
Discovery Grants Program - Individual
Designing and developing processes for plasma immersion ion implantation of metallic surfaces for improving bio- and hemo-compatibility for biomedical devices
设计和开发金属表面等离子体浸没离子注入工艺,以提高生物医学设备的生物和血液相容性
- 批准号:
538280-2018 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Collaborative Research and Development Grants
Development of plasma-based coating processes for medical devices with tailored-range bactericidal properties
开发具有定制杀菌性能的医疗器械等离子涂层工艺
- 批准号:
549867-2020 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Alliance Grants
Biomatériaux Et Bioingénierie Pour L'Innovation En Chirurgie/Biomaterials And Bioengineering For The Innovation In Surgery
Biomatériaux Et Bioingénierie Pour LInnovation En Chirurgie/生物材料和生物工程促进外科创新
- 批准号:
CRC-2018-00091 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Canada Research Chairs
Design, developement and validation of materials and surfaces for innovative biomaterials
创新生物材料的材料和表面的设计、开发和验证
- 批准号:
RGPIN-2015-04434 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Discovery Grants Program - Individual
Plasma-based surface modifications and nano-structured multifunctional coatings for the next generation of biodegradable Mg-based bone-contact implants
用于下一代可生物降解镁基骨接触植入物的等离子体表面改性和纳米结构多功能涂层
- 批准号:
543660-2019 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Collaborative Research and Development Grants
Effects of plasma treatment on natural materials - in particular polysaccharides - for biotechnological applications in health
等离子体处理对天然材料(特别是多糖)的影响,用于健康领域的生物技术应用
- 批准号:
543837-2019 - 财政年份:2021
- 资助金额:
$ 10.91万 - 项目类别:
Collaborative Research and Development Grants
Biomatériaux et Bioingénierie pour l'Innovation en Chirurgie/Biomaterials and Bioengineering for the Innovation in Surgery
Biomatériaux et Bioingénierie pour lInnovation en Chirurgie/生物材料和生物工程促进外科创新
- 批准号:
CRC-2018-00091 - 财政年份:2020
- 资助金额:
$ 10.91万 - 项目类别:
Canada Research Chairs
Plasma-based surface modifications and nano-structured multifunctional coatings for the next generation of biodegradable Mg-based bone-contact implants
用于下一代可生物降解镁基骨接触植入物的等离子体表面改性和纳米结构多功能涂层
- 批准号:
543660-2019 - 财政年份:2020
- 资助金额:
$ 10.91万 - 项目类别:
Collaborative Research and Development Grants
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