High DDA Chitosan/Bacterial Cellulose Nanofibrous Structures by Electrospinning for Wound Dressing

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Scaffolds with nanoscale features can improve many cells functions for a number of tissues such as bone, vascular, bladder, cartilage, neural, skin, etc. These scaffolds may be prepared from various materials including synthetic and natural based biomaterials. In this project we will use two dimensional (2D) nanofibrous structures made from two natural biopolymers, chitosan and bacterial cellulose, using the electrospinning and co-axial electrospinning processes, in the presence of a co-spinning agent, polyethylene oxide. This material can impart high elasticity to the nanofibrous mats, which may be important for wound healing around joints. We are interested more particularly in chitosans with a high degree of deacetylation (DDA) because of their advantageous characteristics such as mechanical properties, biodegradability, immunological activity, wound-healing properties, and osteogenesis enhancement. In our research group, we have developed a strong expertise and knowledge base in the preparation of nanostructures based on chitosan using this process. On the other hand, Axcelon Biopolymers Corporation is active in the area of development of structures and formulations for wound healing, cardiology, tissue engineering and regenerative medicine. The objective of this Engage project is to develop elastic nanofibrous nanostructures made from high DDA chitosans and bacterial cellulose in the area of wound healing. If the results indicate promising potential, then further collaborations will be developed.