Anti-biofilm activity of biophotonic gels

生物光子凝胶的抗生物膜活性

• 批准号: 479284-2015
• 负责人: Wilkinson, Kevin
• 金额: $ 0.91万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=580006
• 关键词: Anti; biofilm; activity; biophotonic; gels

Biophotonic, fluorescent gels have the potential to revolutionize the treatment of bacterial infections and control the growth of bacterial biofilms. In our ongoing Engage collaboration with Klox, the team at the University of Montreal has worked to relate the physicochemical content and structure of the different gel formulations to their effects on a biofilm of Streptococcus mutans (gram positive bacteria commonly found on the teeth). This work has been able to demonstrate that the biophotonic gels produced by Klow work well on the biofilms. Furthermore, the project has identified the gel components that appear to be key with respect to controlling bacterial growth within the biofilms. There is thus great interest in varying the concentrations of each of the active components in the hydrogels in order to optimize both diffusivity into the biofilms and the overall antibacterial effects of the gels. Furthermore, the antibacterial activity of the biophotonic carbopol gels and their mechanism of interaction with the biofilms has not yet been investigated. Therefore, this project will evaluate the antibacterial activity of the gels with different concentrations of urea peroxide (0, 3, 9 and 12%) and different concentrations of the three active fluorophores in the gels. Since the structure of the gels varies according to their method of preparation, different durations of photo-induction (1, 3, 5 minutes or longer, if required) will also be investigated. The study will provide insight into the mechanism of interaction of the gels with the biofilms, which will enable their optimization based upon sound science.

生物光子荧光凝胶有可能彻底改变细菌感染的治疗方法