Development of vascular phantoms for ablation catheter technology optimization

开发血管模型以优化消融导管技术

• 批准号: 508687-2017
• 负责人: Mongrain, Rosaire
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639460
• 关键词: Development; vascular; phantoms; ablation; catheter

Cardiovascular diseases affect 36.9% of the population. It is estimated that 4-5 million people are affected byatrial fibrillation (irregular heart beat) in the US and about 350000 in Canada. An important treatment iscatheter ablation of the erratic conductive cells causing the fibrillation, located near the pulmonary veins ostiain the left atrium. Catheter ablation involves the insertion of a catheter in the groin and directed via the venacava into the right atria. The septal wall between the right atrium and the left atrium is punctured to access thepulmonary veins ostia. The catheter tip delivers energy (radio frequency, cryogenic, ultrasound) to isolate theerratic conductive cells. However, catheter ablation is associated with complications rates of about 4.5%including atrio-esophageal fistula, a life threatening condition. Improvement of the technology requires aprecise assessment of the orientation, positioning, contact forces and navigation through the tissue and deliveryof the energy for achieving the desired isolation while avoiding unwanted perforation and burn/freeze. AgileMV is developing an adjunctive device to ablation catheters that has the potential to provide better positioning,reduce associated potential vessel damage while decreasing the intervention time for an improved patientoutcome and lower hospital/physician costs. In this project, we propose to use a methodology that wedeveloped for making anatomically and biomechanically correct hydrogel vascular phantoms to reproduce thespecific anatomy of the left atrium, right atrium and vena cava to optimize the biomechanical parameters ofAgile MV's design to ensure most favorable treatment. We will use an approach that we developed for othervascular structures (ascending aorta, AAA) and customize it for Agile's project by reconstructing the vena cava,right atrium and left atrium. This approach makes uses of PVA (PolyVinyl Alcohol) to reproduce the elasticproperties of vascular tissue. This provides realistic and reproducible vascular phantoms for testinginterventional technology.

心血管疾病影响36.9%的人口。据估计，在美国有4-5百万人受到房颤（不规则心跳）的影响，在加拿大约有35万人。一个重要的治疗方法是导管消融导致纤颤的不稳定传导细胞，位于左心房肺静脉口附近。导管消融术涉及将导管插入腹股沟并经由腔静脉直接进入右心房。穿刺右心房和左心房之间的间隔壁以进入肺静脉口。导管尖端提供能量（射频、低温、超声波）以隔离不稳定的传导细胞。然而，导管消融术的并发症发生率约为4.5%，包括危及生命的心房食管瘘。该技术的改进需要对定向、定位、贴靠力和通过组织的导航以及能量输送进行精确评估，以实现所需的隔离，同时避免不必要的穿孔和灼伤/冻结。AgileMV正在开发一种消融导管的替代器械，该器械有可能提供更好的定位，减少相关的潜在血管损伤，同时减少干预时间，以改善患者结局并降低医院/医生成本。在本项目中，我们建议使用我们开发的一种方法来制作解剖学和生物力学正确的水凝胶血管模型，以重现左心房、右心房和腔静脉的特定解剖结构，从而优化Agile MV设计的生物力学参数，以确保最有利的治疗。我们将使用我们为其他血管结构（升主动脉，AAA）开发的方法，并通过重建腔静脉，右心房和左心房为Agile的项目定制它。这种方法利用PVA（聚乙烯醇）来复制血管组织的弹性。这为介入技术的测试提供了真实的和可再现的血管体模。