Development of biomechanical dynamic vascular phantoms for pressure sensing technology assessment

用于压力传感技术评估的生物力学动态血管模型的开发

• 批准号: 562464-2021
• 负责人: Mongrain, Rosaire
• 金额: $ 5.22万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722097
• 关键词: Development; biomechanical; dynamic; vascular; phantoms

According to the American Heart Association cardiovascular disease affects 36.9% of the population, with approximately 30% of patients suffering from coronary artery disease. Acute Coronary Syndrome, associated with myocardial infarction, requires fast diagnosis and revascularization. Traditionally clinicians have chosen treatment methods by estimating the amount of flow going through the diseased coronary artery. Although several methods exist, catheter based pressure measurements are widespread among clinicians. Fractional flow reserve (FFR) is an index of the physiological significance of a coronary stenosis and is a measure of the maximal blood flow in a diseased artery to normal maximal flow. It is measured by comparing the pressure before and after the diseased arterial section, and thus indirectly estimating the loss of myocardial perfusion. Opsens has developed a FFR technology based on a photonic principle instead of the piezoelectric principle of the conventional technologies. This new photonic based technology has the potential to be more sensitive than current piezoelectric based technologies. Our partner is in the stage of evaluating the navigation and positioning precision of their technology (delivery in tortuous vessels and positioning at the stenotic site). We propose developing a dedicated dynamic phantom in-vitro model to study the navigation and positioning parameters and the associated hemodynamic disturbances associated with the technology.

根据美国心脏协会的数据，心血管疾病影响36.9%的人口，其中约30%的患者患有冠状动脉疾病。急性冠状动脉综合征与心肌梗死相关，需要快速诊断和血运重建。传统上，临床医生通过估计通过患病冠状动脉的流量来选择治疗方法。尽管存在几种方法，但基于导管的压力测量在临床医生中广泛使用。 血流储备分数（FFR）是冠状动脉狭窄生理意义的指标，是病变动脉中最大血流量与正常最大血流量的量度。通过比较患病动脉段前后的压力来测量，从而间接估计心肌灌注的损失。Opsens开发了一种基于光子原理而不是传统技术的压电原理的FFR技术。这种新的基于光子的技术有可能比目前基于压电的技术更敏感。我们的合作伙伴正在评估其技术的导航和定位精度（在迂曲血管中输送和在狭窄部位定位）。我们建议开发一种专用的动态体模体外模型，以研究导航和定位参数以及与该技术相关的血流动力学干扰。