Development of biomechanical dynamic vascular phantoms for pressure sensing technology assessment

用于压力传感技术评估的生物力学动态血管模型的开发

基本信息

批准号：
562464-2021
负责人：
Mongrain, Rosaire
金额：
$ 5.22万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Alliance Grants
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722097
关键词：
Development biomechanical dynamic vascular phantoms

项目摘要

According to the American Heart Association cardiovascular disease affects 36.9% of the population, with approximately 30% of patients suffering from coronary artery disease. Acute Coronary Syndrome, associated with myocardial infarction, requires fast diagnosis and revascularization. Traditionally clinicians have chosen treatment methods by estimating the amount of flow going through the diseased coronary artery. Although several methods exist, catheter based pressure measurements are widespread among clinicians. Fractional flow reserve (FFR) is an index of the physiological significance of a coronary stenosis and is a measure of the maximal blood flow in a diseased artery to normal maximal flow. It is measured by comparing the pressure before and after the diseased arterial section, and thus indirectly estimating the loss of myocardial perfusion. Opsens has developed a FFR technology based on a photonic principle instead of the piezoelectric principle of the conventional technologies. This new photonic based technology has the potential to be more sensitive than current piezoelectric based technologies. Our partner is in the stage of evaluating the navigation and positioning precision of their technology (delivery in tortuous vessels and positioning at the stenotic site). We propose developing a dedicated dynamic phantom in-vitro model to study the navigation and positioning parameters and the associated hemodynamic disturbances associated with the technology.

根据美国心脏协会，心血管疾病影响了36.9％的人口，大约30％患有冠状动脉疾病的患者。与心肌梗塞相关的急性冠状动脉综合征需要快速诊断和血运重建。传统上，临床医生通过估计通过患病动脉的流量量来选择治疗方法。尽管存在几种方法，但基于导管的压力测量在临床医生中广泛存在。分数流量储备（FFR）是冠状动脉狭窄的生理意义的指数，是衡量患病动脉中最大血流至正常最大流动的指标。它是通过比较患病动脉剖面前后的压力来测量的，从而间接估计心肌灌注的损失。 Opsens开发了一种基于光子原理的FFR技术，而不是传统技术的压电原理。这项新的基于光子的技术具有比目前基于压电的技术更敏感的。我们的合作伙伴处于评估其技术的导航和定位精度的阶段（曲折的船只和狭窄地点的定位）。我们建议开发一个专用的动态幻影范围内电体模型，以研究导航和定位参数以及与技术相关的相关血液动力学障碍。