Synthesis and Functionalisation of nanomaterials by short pulse laser and its applications

短脉冲激光纳米材料的合成、功能化及其应用

• 批准号: RGPIN-2017-04425
• 负责人: Venkatakrishnan, Krishnan
• 金额: $ 2.26万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667707
• 关键词: Synthesis; Functionalisation; nanomaterials; short; pulse

My research group has made important findings in short-pulsed laser nano material synthesis directly from solid targets (without the employment of chemical agents) and its functionalisation for various applications. We have discovered that synthesized nano-materials possess multiple phases & various morphologies, and exhibit unique optical and biochemical properties (new functionalities), none of which have been observed before. The impurity-free synthesis makes these nano-materials particularly suitable for sensing, environmental and biomedical applications. The proposed program both continues and expands upon this research. ******We aim to uncover and demonstrate the fundamentals of nano-material formation and our research findings will give us a better understanding of the physics of nano-material formation, which will allow us to meet one of the main objectives of this research: to tailor the functionality of nano-materials to specific applications in chemical, biomedical and defense arenas. ******1) Contrast agent for ultrabright fluorescent imaging: A synthesised nano template provides tremendous potential towards the photon sensitization of metallic, semiconductor and magnetic-based nanomaterials and thereafter for enhanced photoluminance, which could be used as an agent to increase the contrast of florescent microscopy cellular imaging.*** ***2) SERS-based ultrasensitive detection: This research program will investigate non-plasmonic SERS & apply the knowledge to develop techniques for in-situ monitoring of cell activity, sensing toxic chemicals, and detecting traces of explosives from standoff distances. ******3)All-in-one therapeutic agents: Many of these engineered Bio Nano-Materials are multi-functionalized, such as with SERS enhancement, fluorescent enhancement and biocompatibility. Research of these bio-nanomaterials may lead to new cancer therapeutics that integrates several functions into a single medication that would enable mutli-mode diagnoses and impede the growth of cancer cells with no side effects on healthy cells. Our research in this area will contribute significantly to the improvement of the specificity, selectivity and safety of cancer nanomedicine. ******4)Rapid healing wound dressing and antibacterial coating for textiles: The bioactivity and biocompatibility of the engineered 3-D nanostructures will be used for developing new bio-functionalized scaffolds and implantable materials in regenerative medicine and clinical tissue engineering, and the knowledge gained will be used to develop wound dressing and self-cleaning cloth for soldiers. ******In summary, the proposed research is multidisciplinary in nature and will result in high quality HQP training in the synthesis and functionalisation of next-generation nano-materials for diverse applications in chemical/bio sensing, defence, cancer therapy, wound healing and diagnostic applications.**

我的研究小组在直接从固体靶(不使用化学试剂)合成短脉冲激光纳米材料及其各种应用的功能化方面取得了重要发现。我们已经发现，合成的纳米材料具有多相和不同的形貌，并表现出独特的光学和生化性质(新的功能)，这些都是以前没有观察到的。无杂质的合成使这些纳米材料特别适合于传感、环境和生物医学应用。拟议的计划既是对这项研究的继续，也是对其的扩展。*我们的目标是揭示和展示纳米材料形成的基本原理，我们的研究成果将使我们更好地理解纳米材料形成的物理学，这将使我们能够实现本研究的主要目标之一：为化学、生物医学和国防领域的特定应用定制纳米材料的功能。*1)超亮荧光成像造影剂：合成的纳米模板为金属、半导体和磁性纳米材料的光子敏化提供了巨大的潜力，从而增强了光致发光，可用作提高荧光显微镜细胞成像对比度的试剂。*2)基于SERS的超灵敏检测：该研究计划将研究非等离子SERS，并应用这些知识开发技术，用于现场监测细胞活动，传感有毒化学物质，并从远距离检测爆炸物的痕迹。*3)多功能治疗剂：许多生物纳米工程材料是多功能的，例如增强SERS、增强荧光和生物兼容性。对这些生物纳米材料的研究可能会导致新的癌症疗法，将几种功能整合到一种药物中，从而实现多种模式的诊断，并在不对健康细胞产生副作用的情况下阻碍癌细胞的生长。我们在这方面的研究将有助于提高肿瘤纳米药物的特异性、选择性和安全性。*4)快速愈合伤口敷料和纺织品抗菌涂层：将利用工程三维纳米结构的生物活性和生物相容性，在再生医学和临床组织工程中开发新型生物功能化支架和植入材料，并将所获得的知识用于开发士兵伤口敷料和自洁布料。*总而言之，拟议的研究是多学科性质的，将在下一代纳米材料的合成和功能化方面产生高质量的HQP培训，用于化学/生物传感、国防、癌症治疗、伤口愈合和诊断应用。**