Synthesis and Functionalisation of nanomaterials by short pulse laser and its applications

短脉冲激光纳米材料的合成、功能化及其应用

• 批准号: RGPIN-2017-04425
• 负责人: Venkatakrishnan, Krishnan
• 金额: $ 2.26万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=684092
• 关键词: Synthesis; Functionalisation; nanomaterials; short; pulse

My research group has made important findings in short-pulsed laser nano material synthesis directly from solid targets (without the employment of chemical agents) and its functionalisation for various applications. We have discovered that synthesized nano-materials possess multiple phases f nano-material formation, which will allow us to meet one of the main objectives of this research: to tailor the functionality of nano-materials to specific applications in chemical, biomedical and defense arenas. ******1) Contrast agent for ultrabright fluorescent imaging: A synthesised nano template provides tremendous potential towards the photon sensitization of metallic, semiconductor and magnetic-based nanomaterials and thereafter for enhanced photoluminance, which could be used as an agent to increase the contrast of florescent microscopy cellular imaging.*** ***2) SERS-based ultrasensitive detection: This research program will investigate non-plasmonic SERS & apply the knowledge to develop techniques for in-situ monitoring of cell activity, sensing toxic chemicals, and detecting traces of explosives from standoff distances. ******3)All-in-one therapeutic agents: Many of these engineered Bio Nano-Materials are multi-functionalized, such as with SERS enhancement, fluorescent enhancement and biocompatibility. Research of these bio-nanomaterials may lead to new cancer therapeutics that integrates several functions into a single medication that would enable mutli-mode diagnoses and impede the growth of cancer cells with no side effects on healthy cells. Our research in this area will contribute significantly to the improvement of the specificity, selectivity and safety of cancer nanomedicine. ******4)Rapid healing wound dressing and antibacterial coating for textiles: The bioactivity and biocompatibility of the engineered 3-D nanostructures will be used for developing new bio-functionalized scaffolds and implantable materials in regenerative medicine and clinical tissue engineering, and the knowledge gained will be used to develop wound dressing and self-cleaning cloth for soldiers. ******In summary, the proposed research is multidisciplinary in nature and will result in high quality HQP training in the synthesis and functionalisation of next-generation nano-materials for diverse applications in chemical/bio sensing, defence, cancer therapy, wound healing and diagnostic applications.**

我的研究小组在直接从固体靶材合成短脉冲激光纳米材料（不使用化学试剂）及其针对各种应用的功能化方面取得了重要发现。我们发现合成的纳米材料具有纳米材料形成的多个阶段，这将使我们能够实现这项研究的主要目标之一：根据化学、生物医学和国防领域的特定应用定制纳米材料的功能。 ******1) 用于超亮荧光成像的造影剂：合成的纳米模板为金属、半导体和磁性纳米材料的光子敏化以及随后增强的光致发光提供了巨大的潜力，可用作增加荧光显微镜细胞成像对比度的试剂。*** ***2) 基于 SERS 的超灵敏检测：该研究计划将研究 非等离子体表面增强拉曼光谱 (SERS) 并应用这些知识来开发原位监测细胞活动、感测有毒化学物质以及从远距离检测爆炸物痕迹的技术。 ******3）多合一治疗剂：许多工程生物纳米材料都是多功能的，例如具有SERS增强、荧光增强和生物相容性。这些生物纳米材料的研究可能会带来新的癌症疗法，将多种功能集成到单一药物中，从而实现多模式诊断并阻止癌细胞的生长，而不会对健康细胞产生副作用。我们在这一领域的研究将对提高癌症纳米医学的特异性、选择性和安全性做出重大贡献。 ******4）快速愈合伤口敷料和纺织品抗菌涂层：工程3D纳米结构的生物活性和生物相容性将用于开发再生医学和临床组织工程中的新型生物功能化支架和植入材料，所获得的知识将用于开发士兵伤口敷料和自洁布。 ******总之，拟议的研究本质上是多学科的，并将在下一代纳米材料的合成和功能化方面带来高质量的 HQP 培训，用于化学/生物传感、国防、癌症治疗、伤口愈合和诊断应用等多种应用。 **