Evidence-based guidance for mitigating COVID-19 virus droplet transmission and surface contamination

减轻 COVID-19 病毒飞沫传播和表面污染的循证指南

基本信息

批准号：
552691-2020
负责人：
Savory, Eric
金额：
$ 3.64万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Alliance Grants
财政年份：
2020
资助国家：
加拿大
起止时间：
2020-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=701818
关键词：
Evidence based guidance mitigating COVID

项目摘要

The proposed research, in collaboration with a major manufacturer of personal protective equipment (PPE) (3M Canada) and a company specializing in instrumentation and medical device design (Corus Product Design), brings together engineers and virologists at Western to develop and implement a novel aerosolization chamber in the new $16 million biocontainment level 3 ImPaKT lab that will allow aerosols of COVID-19 to be produced, via a new pulsed generator, that closely mimic those from coughs and sneezes. Samples of different materials, including PPE, will be placed in the chamber to examine the transport and deposition of viral droplets on their surface under different temperature and humidity conditions. This more realistic approach removes the adhesion and penetration bias associated with the current practice of directly placing droplets on the surface using pipettes or syringes, which has implications on the subsequent effectiveness of any PPE decontamination procedures. There is particular urgency for Canada in undertaking reliable COVID-19 transmission and surface decontamination experiments, under different ambient conditions, because there is evidence from other countries that indoor air-conditioned public spaces (e.g. shopping malls) may promote transmission during the summer months. The collaboration with 3M Canada will allow the research findings related to the use and decontamination of PPE to be effectively communicated to product users as well as to regulatory bodies, whilst Corus Product Design will assist in the development of the final version of the facility that they will then market to research laboratories world-wide, together with test methodologies and procedures, to ensure that such research and testing is conducted in a standardized manner, with COVID-19 and any future viruses.

The proposed research, in collaboration with a major manufacturer of personal protective equipment (PPE) (3M Canada) and a company specializing in instrumentation and medical device design (Corus Product Design), brings together engineers and virologists at Western to develop and implement a novel aerosolization chamber in the new $16 million biocontainment level 3 ImPaKT lab that will allow aerosols of COVID-19 to be produced, via a new pulsed generator, that closely模仿那些咳嗽和打喷嚏的人。包括PPE在内的不同材料的样品将放置在腔室中，以检查在不同温度和湿度条件下病毒液滴在其表面上的运输和沉积。这种更现实的方法消除了与当前使用移液器或注射器直接将液滴直接放在表面上的实践相关的粘附和穿透性偏差，这对任何PPE去污染程序的后续有效性都有影响。在不同的环境条件下，加拿大在进行可靠的Covid-19传播和表面净化实验方面特别紧迫，因为还有其他国家的证据表明，室内空调的公共场所（例如购物中心）可能会在夏季促进传播。与加拿大3M的合作将允许与PPE的使用和去污染有关的研究结果，可以有效地传达给产品用户以及监管机构，而Corus产品设计将有助于开发最终版本的设施，然后他们将其推销到全球范围内研究实验室，并与测试方法和过程进行研究，以确保9个标准化和测试方法，并进行了标准化的方式，并进行了确定的方法，并确保了实现的行为。