Structure and temperature adaptation of chaperonin TF55 from Sulfolobus solfataricus

我们的工作在未来的生物技术和医学治疗方面都有潜力。伴侣蛋白亚基形成的笼子及其与特定靶标结合的能力可能导致其作为纳米囊泡的应用，可以促进真核蛋白在细菌中的表达，并有助于防止或溶解蛋白质聚集。随着澳大利亚人口的老龄化，我们可以预期，阿尔茨海默病和帕金森病等疾病以及其他由蛋白质错误折叠和聚集引起的疾病，包括肌病和白内障，将越来越普遍。伴侣蛋白参与了这些与年龄有关的疾病，需要详细的结构和功能研究。

Our work has future potential both for biotechnology and for medical therapies. The cages formed by chaperonin subunits and their ability to bind to specific targets could lead to their application as nano-vesicles, could facilitate expression of eukaryotic proteins in bacteria and could help to prevent or dissolve protein aggregates. With Australia's ageing population, we can expect an increasing prevalence of pathologies such as Alzheimer's and Parkinson's disease and other diseases that arise from protein mis-folding and aggregation, including myopathies and cataracts. A participation of chaperonins has been implicated in these age-related diseases and demands detailed structural and functional investigations.